Safety evaluation of certain food additives - ipcs inchem

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ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS 301 Table 2. Annual volumes of production of aliphatic branched-chain saturated and unsaturated alcohols, aldehydes, acids and related esters used as flavouring agents in Europe, the USA and Japan Flavouring agent (No.) Most recent annual volume (kg) a Ethyl (E)-2-methyl-2-pentenoate (1815) Intakeb Annual volume from natural occurrence in foods (kg) c Consumption ratiod μg/day μg/kg bw per day Europe ND ND ND USA 6 0.7 0.01 + NA Japan 2-Methylbutyl 3-methyl- 2-butenoate (1816) ND ND ND Europe ND ND ND USA 200 24 0.4 NA Japan (±)(E,Z)-5-(2,2- Dimethylcyclopropyl)-3-methyl- 2-pentenal (1817) ND ND ND Europe 0.1 0.01 0.0002 USA ND ND ND NA Japan (E,Z)-4-Methylpent-2-enoic acid (1818) ND ND ND Europe ND ND ND USA 0.4 0.05 0.001 + NA Japan (±)-4-Ethyloctanal (1819) ND ND ND Europe 0.1 0.01 0.0002 USA 1 0.1 0.002 NA Japan (E)-Geranyl 2-methylbutyrate (1820) ND ND ND Europe 0.1 0.01 0.0002 USA ND ND ND + NA Japan 0.1 0.03 0.0004
302 ALIPHATIC BRANCHED-CHAIN SATURATED AND UNSATURATED ALCOHOLS Table 2 (contd) Flavouring agent (No.) Most recent annual volume (kg) a (E)-Geranyl valerate (1821) Intake b Annual volume μg/day μg/kg bw per day from natural occurrence in foods (kg) c Europe ND ND ND USA 555 68 1.1 NA Japan (E)-Geranyl tiglate (1822) 0.2 0.05 0.001 Europe 16 2 0.03 USA 0.6 0.08 0.001 + NA Japan (E)-Citronellyl 2-methylbut- 2-enoate (1823) 4 1 0.02 Europe 0.2 0.02 0.0003 USA ND ND ND NA Japan (E)-Ethyl tiglate (1824) 0.8 0.2 0.003 Europe 44 5 0.08 USA 6 0.8 0.01 + NA Japan (E,Z)-Geranic acid (1825) 5 1 0.02 Europe 0.4 0.04 0.001 USA 0.3 0.03 0.001 5e 17 Japan Prenyl formate (1826) 1 0.3 0.01 Europe 0.1 0.01 0.0002 USA 1 0.1 0.002 + NA Japan ND ND ND Consumption ratio d
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WHO FOOD ADDITIVES SERIES: 60 Safet
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CONTENTS Preface ..................
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PREFACE The monographs contained in
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ASPARAGINASE FROM ASPERGILLUS NIGER
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16 CALCIUM LIGNOSULFONATE (40-65) 1
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18 CALCIUM LIGNOSULFONATE (40-65) ~
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20 CALCIUM LIGNOSULFONATE (40-65) A
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22 CALCIUM LIGNOSULFONATE (40-65) c
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24 CALCIUM LIGNOSULFONATE (40-65) T
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28 CALCIUM LIGNOSULFONATE (40-65) i
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ETHYL LAUROYL ARGINATE First draft
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ETHYL LAUROYL ARGINATE 41 and Devel
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ETHYL LAUROYL ARGINATE 43 lauroyl a
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ETHYL LAUROYL ARGINATE 45 arginine.
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ETHYL LAUROYL ARGINATE 47 resulting
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ETHYL LAUROYL ARGINATE 49 Table 4.
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ETHYL LAUROYL ARGINATE 51 weight ch
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ETHYL LAUROYL ARGINATE 53 stomach l
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ETHYL LAUROYL ARGINATE 55 fibrosis
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ETHYL LAUROYL ARGINATE 57 Table 5 (
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ETHYL LAUROYL ARGINATE 59 first 4 d
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ETHYL LAUROYL ARGINATE 61 The gener
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ETHYL LAUROYL ARGINATE 63 treatment
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ETHYL LAUROYL ARGINATE 65 gestation
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ETHYL LAUROYL ARGINATE 67 Body weig
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ETHYL LAUROYL ARGINATE 69 Table 6.
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ETHYL LAUROYL ARGINATE 77 About 99%
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ETHYL LAUROYL ARGINATE 79 concentra
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ETHYL LAUROYL ARGINATE 81 theoretic
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ETHYL LAUROYL ARGINATE 83 Huntingdo
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PAPRIKA EXTRACT First draft prepare
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PAPRIKA EXTRACT 87 of capsanthin ra
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PAPRIKA EXTRACT 89 biochemical para
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PAPRIKA EXTRACT 91 Table 1. Sales o
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PAPRIKA EXTRACT 93 Table 2. Estimat
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PAPRIKA EXTRACT 95 The European Sci
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PAPRIKA EXTRACT 97 The potential di
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PAPRIKA EXTRACT 99 Hornero-Mendez,
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PAPRIKA EXTRACT 101 Appendix 1. Res
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PAPRIKA EXTRACT 103 Appendix 1. (co
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PAPRIKA EXTRACT 105 Appendix 1. (co
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108 PHOSPHOLIPASE C EXPRESSED IN PI
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PHYTOSTEROLS, PHYTOSTANOLS AND THEI
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166 POLYDIMETHYLSILOXANE (addendum)
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STEVIOL GLYCOSIDES (addendum) First
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STEVIOL GLYCOSIDES (addendum) 185 r
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STEVIOL GLYCOSIDES (addendum) 187 c
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STEVIOL GLYCOSIDES (addendum) 189 a
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STEVIOL GLYCOSIDES (addendum) 191 N
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STEVIOL GLYCOSIDES (addendum) 193 2
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STEVIOL GLYCOSIDES (addendum) 195 T
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STEVIOL GLYCOSIDES (addendum) 197 a
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STEVIOL GLYCOSIDES (addendum) 199 r
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STEVIOL GLYCOSIDES (addendum) 201 l
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STEVIOL GLYCOSIDES (addendum) 203 g
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STEVIOL GLYCOSIDES (addendum) 209 t
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STEVIOL GLYCOSIDES (addendum) 211 t
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STEVIOL GLYCOSIDES (addendum) 213 s
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STEVIOL GLYCOSIDES (addendum) 215 C
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STEVIOL GLYCOSIDES (addendum) 217 L
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STEVIOL GLYCOSIDES (addendum) 219 W
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222 SULFITES: ASSESSMENT OF DIETARY
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Page 257 and 258: 250 SULFITES: ASSESSMENT OF DIETARY
Page 268: SAFETY EVALUATIONS OF GROUPS OF REL
Page 271 and 272: 264 INTRODUCTION Figure 1. Procedur
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ALKOXY-SUBSTITUTED ALLYLBENZENES PR
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FURAN-SUBSTITUTED ALIPHATIC HYDROCA
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HYDROXY- AND ALKOXY-SUBSTITUTED BEN
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MISCELLANEOUS NITROGEN-CONTAINING S
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580 SUBSTANCES STRUCTURALLY RELATED
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ANNEXES
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598 ANNEX 1 10. Specifications for
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600 ANNEX 1 No. 54, 1974; WHO Techn
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602 ANNEX 1 70. Evaluation of certa
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604 ANNEX 1 108. Toxicological eval
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606 ANNEX 1 148. Residues of some v
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608 ANNEX 1 188. Safety evaluation
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610 ANNEX 2 ECG electrocardiogram E
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612 ANNEX 2 SI stimulation index SU
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614 ANNEX 3 Ms J. Baines, Food Stan
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ANNEX 4 ACCEPTABLE DAILY INTAKES, O
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ANNEX 4 619 Food additive Specifica
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ANNEX 4 621 3. FLAVOURING AGENTS 3.
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ANNEX 4 623 Flavouring agent No. Sp
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ANNEX 4 625 Flavouring agent JECFA
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ANNEX 4 627 Actual production volum
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ANNEX 4 629 Flavouring agent No. Sp
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ANNEX 5 SUMMARY OF THE SAFETY EVALU
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ANNEX 5 633 Secondary components Co
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