Safety evaluation of certain food additives - ipcs inchem

424 ALKOXY-SUBSTITUTED ALLYLBENZENES
Table 4 (contd)
No. Flavouring agent End-point Test object Concentration Results References
1792 Safrole UDS Rat hepatocytes 0.001, 0.01, 0.1, 1, 10 and 100 μg/ml Positive Williams et al. (1985)
1792 Safrole UDS Rat hepatocytes 0.162–1620 μg/ml o (10 6 –10 2 mol/l) Positive Glauert et al. (1985)
1792 Safrole UDS Rat hepatocytes 0.0162–162 μg/ml o (10 7 –10 3 mol/l) Positive h Chan & Caldwell (1992)
1792 Safrole UDS Rat hepatocytes 162 μg/ml o (10 3 mol/l) Positive Howes et al. (1990a, 1990b)
1792 Safrole UDS Rat hepatocytes 1.62–162 μg/ml o (10–1000 μmol/l) Positive Burkey et al. (1998)
1792 Safrole UDS Mouse hepatocytes 0.0162–162 μg/ml o (0.1–1000 μmol/l) Positive oo Burkey et al. (2000)
1792 Safrole UDS Rat hepatocytes 0.0162–162 μg/ml o (0.1–1000 μmol/l) Positive k Burkey et al. (2000)
1792 Safrole UDS Rat hepatocytes 81 μg/ml o (500 nmol/ml) Negative Probst et al. (1981)
1792 Safrole UDS Rat hepatocytes 0.162–1620 μg/ml o (10 6 –10 2 mol/l) Positive Althaus et al. (1982)
1792 Safrole UDS HeLa cells Not provided Negative Martin et al. (1978)
1792 Safrole UDS Human skin fibroblasts 0.162–16.2 μg/ml o (10 6 –10 4 mol/l) Negative San & Stich (1975)
Negative Probst & Hill (1985)
1792 Safrole UDS Rat hepatocytes 0.08, 0.16, 0.8, 1.6, 8, 16, 80 and
160 μg/ml
1792 Safrole UDS HeLa cells 25–250 μg/ml Positive d Martin & Campbell (1985)
1792 Safrole UDS HeLa cells 0.01, 0.05, 0.1, 0.5 and 1.0 μg/ml Positive d Barrett (1985)
1792 Safrole UDS Human skin fibroblast cells Not provided Negative f Agrelo & Amos (1981)
1792 Safrole UDS Human fibroblast cells 0.032, 0.16, 0.8, 4.0, 20.0 and 100.0 μg/ml Negative Agrelo & Severn (1981)
1792 Safrole UDS Human fibroblast WI-38 cells 3.29–44 μg/ml r (0.003–0.04 μl/ml) Negative g Robinson & Mitchell (1981)