LIVE POLIO IRUS VACCINES

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Page 6. Vaccination of Full-Term Infants with Attenuated Polioviruses-Stanley A. Plotkin, Joseph S. Pagano, and Hilary Koprowski... ............................... 294 7. The Response of Newborn Infants to Vaccination with Living Type 1 Poliovirus (Sabin-LSc, 2ab)--Preliminary Report-Martha Lipson Lepow, Robert J. Warren, Nigel Gray, and Frederick C. Robbins .............. .................. 302 8. Preliminary Report on the Susceptibility of Newborn Infants to Infection with Poliovirus Strains in an Attenuated Virus Vaccine-Henry M. Gelfand, Dorothy R. LeBlanc, Alfonso H. Holguin, and John P. Fox ............................. 308 9. Immunization of Newborn Infants with Live Attenuated Poliovirus Vaccine-Saul ·Krugman, Joel Warren, Marvin S. Eiger, Peter H. Berman, Richard H. Michaels, and Albert B. Sabin . ....................................... 315 Discussion ........................................................ ....... 322 (c) Influence oj Dosage and Regimen 10. Recent Experience with the Lederle Trivalent Oral Poliomyelitis Vaccine-Herald R. Cox, Victor J. Cabasso, Juan Embil, Jr., Floyd S. Markham, Max J. Moses, Arden W. Moyer, Manuel Roca-García, and J. M. Ruegsegger ................ 330 11. Further Experiences with Oral Poliomyelitis Vaccines in Minnesota-Herman Kleinman, Robert N. Barr, Henry Bauer, Anne C. Kimball, Marion K. Cooney, Jacob E. Bearman, and Wayne E. Mathey . .............................. 341 SIXTH SESSION, Wednesday, 8 June 1960, 2:00 p.m. Chairman: DR. PIERRE R. LÉPINE TOPIC III. EFFICACY. (A) LABORATORY EVIDENCE (continuation) (1) ANTIBODY RESPONSE (c) Influence of Dosage and Regimen 12. Minnesota Studies with Oral Poliomyelitis Vaccines-Henry Bauer, Robert N. Barr, Herman Kleinman, Anne C. Kimball, Marion K. Cooney, Jacob E. Bearman, and Wayne E. Mathey . . ................... .... 357 13. Use of Attenuated Live Poliovirus Vaccine in Cuban Children-Juan Embil, Jr., Luis Gervais, Carlos Hernández Miyares, and Gustavo Cardelle ................. 365 Discussion ................... .......... ................................... 371 (2) INTERFERENCE BY HETEROTYPIC POLIO- VIRUSES OR BY OTHER VIRUSES 14. Effects of Rapid Mass Immunization of a Population with Live, Oral Poliovirus Vaccine under Conditions of Massive Enteric Infection with Other Viruses- Albert B. Sabin and M. Ramos Alvarez, J. Alvarez Amézquita, W. Pelon, R. H. Michaels, I. Spigland, M. Koch, J. Barnes, and J. Rhim ....................... 377 15. Use of Sabin's Live Poliovirus Vaccine in Mexico. Results of a Large-Scale Trial- Manuel Ramos Alvarez, Miguel E. Bustamante, and Rafael Alvarez Alba ...... 386 Discussion ........ ....................... ................... 410 viii
TOPIC III. EFFICACY. (B) FIELD EVIDENCE Page 16. On the Course of Mass Immunization of the Population in the Soviet Union with the Live Poliovirus Vaccine from Albert B. Sabin's Strains-M. P. Chumakov, M. K. Voroshilova, S. G. Drozdov, S. G. Dzagurov, V. A. Lashkevich, L. L. Mironova, N. M. Ralph, I. S. Sokolova, I. N. Dobrova, E. E. Ashmarina, G. A. Shirman, G. P. Fleer, V. I. Zhevandrova, G. A. Koroleva, E. A. Tolskaya, O. D. Yankevich, K. A. Vasilieva, T. R. Kuslap, T. S. Podsedlovsky, Y. S. Uspensky, V. M. Boiki, and K. M. Sinyak....................................................... 413 Discussion .............................................................. . 429 SEVENTH SESSION, Thursday, 9 June 1960, 9:00 a.m. Chairman: DR. ANDREW J. RHODES TOPIC III. EFFICACY. (B) FIELD EVIDENCE (continuation) 17. A Preliminary Report on a Large-Scale Field Trial with the Oral Cox-Lederle Attenuated Poliomyelitis Vaccine in Dade County (Miami), Florida-M. E. Flipse, G. M. Erickson, W. R. Hoffert, M. M. Sigel, N. J. Schneider, L. B. Clayton, A. W. Menzin, R. E. Markush, F. Howell, Jr., M. 1. Crossley, T. E. Cato, A. V. Hardy, and F. J. Evans .............................................. 4....... 435 18. Preliminary Report of Epidemiological Surveillance in a Mass Field Trial with Oral Polio Vaccine-G. M. Erickson, M. E. Flipse, A. W. Menzin, L. B. Clayton, R. E. Markush, and A. V. Hardy ............-............................. 445 Discussion ............................................................... 457 19. Vaccination with the CHAT Strain of Type 1 Attenuated Poliomyelitis Virus in Leopoldville, Belgian Congo. III. Safety and Efficacy during the First Twentyone Months of Study-Stanley A. Plotkin, André Lebrun, Ghislain Courtois, and Hilary Koprowski .................................................... 466 20. Live Virus Vaccine Studies in Southern Africa-James H. S. Gear ....... .. 474 Discussion ................................................................. 480 21. Material on the Immunological and Epidemiological Effectiveness of Live Poliomyelitis Vaccine-A. A. Smorodintsev, A. I. Drobyshevskaya, N. P. Bulychev, O. M. Chalkina, G. M. Groisman, V. I. Ilyenko, R. A. Kantorovich, L. M. Kurnosova, K. G. Vasiliev, V. 1. Votiakov, and G. P. Zhilova ..... ........ 482 EIGHTH SESSION, Thursday, 9 June 1960, 2:00 p.m. Chairman: DR. CHARLES H. STUART-HARRIS TOPIC III. EFFICACY. (B) FIELD EVIDENCE (continuation) Discussion ................................................................. 505 22. Further Observations in Conjunction with the First Field Trial with Live Poliovirus Vaccine in Czechoslovakia. Epidemiological Study-Vilém Skovránek ........ 507 ix
Page 1 and 2: LIVE POLIO IRUS VACCINES Papers Pre
Page 3 and 4: SECOND INTERNATIONAL CONFERENCE ON
Page 5: Preface The accumulation of informa
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Page 12 and 13: Page 23. Vaccination against Poliom
Page 14 and 15: Dr. Ghislain COURTOIS Director, Pri
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Page 21 and 22: 4 Introductory Remarks 4 Introducto
Page 23 and 24: 6 General Considerations immunity a
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Page 27 and 28: 10 General Considerations 10 Genera
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DISCUSSION CHAIRMAN ANDERSON: Thank
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46 Discussion a paralytic case. Thi
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48 Discussion + - + + I + - I + + 1
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50 Discussion sages of neurovirulen
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Application of Genetic Markers to D
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Discussion 67 TABLE 1. INCIDENCE OF
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Experimental Studies on Animals wit
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6. DETECTION OF A "NON-DETECTABLE"
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Detection of a "Non-Detectable" Sim
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Discussion 87 Dr. Koprowski's state
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Discussion 89 recognize its effects
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Laboratory Investigations of Attenu
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Discussion 99 In the case of Table
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8. BEHAVIOR OF COLD MUTANTS OF POLI
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Behavior of Cold Mutants of Poliovi
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DISCUSSION CHAIRMAN BURNET: Thank y
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114 Safety-Field Evidence of Safety
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118 S afety-Field Evidence of S af
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122 Discussion 122 Discussion~~~~~~
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10. LABORATORY INVESTIGATIONS OF TH
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126 VIRUS 1 MAhONEY Safety-Field Ev
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128 Safety-Field Evidence óf Safet
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DISCUSSION CHAIRMAN ZHDANOV: This p
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11. EPIDEMIOLOGICAL AND VIROLOGICAL
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12. SPREAD OF A VACCINE STRAIN OF P
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148 Saf ety-Field Evidence of Saf e
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152 Saf ety-Field Evidence of Safet
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DISCUSSION CHAIRMAN ZHDANOV: The pa
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158 Discussion 158 Díscussion~~~~~
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160 Discussion specimens. We were u
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. . . 168 Safety-Field Evidence of
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14. THE CAPACITY OF LIVE ATTENUATED
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176 Saf ety-Field Evidence of Saf e
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Field, Laboratory Experiences With
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16. STUDIES ON LIVE POLIOVIRUS VACC
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Studies on Live Poliovirus Vaccine
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Da. HORSTMANN: If I may answer for
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Discussion 205 Discussion 205 tried
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NOTE: The Spanish translation of th
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Vaccination of Pregnant Women and Y
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Development and Persistence of Poli
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Virologic, Serologic Investigations
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_ _ _ _ _ _ _ _ Virologic, Serologi
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cARE NUC:4I Discussion 267 CUAw # J
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Discussion 269 in the investigation
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Virological Findings, Antibody Resp
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4. ROUTINE IMMUNIZATION WITH ATTENU
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Routine Immunization With Attenuate
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Experimental Infectionwith CHATAtte
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Experimental Infection with CHATAtt
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Experimental Infection with CHATAtt
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Vaccination of Full-Term Infants wi
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Response of Newborn Infants to Vacc
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Susceptibility of Newborn Infants t
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9. IMMUNIZATION OF NEWBORN INFANTS
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Immunization of Newborn Infants wit
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Discussion 323 vaccinated siblings
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Discussion 325 Discussion 325 ance
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transplacental antibodies, or antib
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Discussion 329 Discussion 329 born
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Recent Experience with Lederle Triv
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11. FURTHER EXPERIENCES WITH ORAL P
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Further Experiences with Oral Polio
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Minnesota Studies with Oral Poliomy
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13. USE OF ATTENUATED LIVE POLIOVIR
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Use of Attenuated Live Poliovirus V
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Use of Attenuated Live Poliovirus V
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DISCUSSION CHAIRMAN LÉPINE: The tw
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Discussion 373 -~~~~~~ics o 7 domin
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Discussion 375 -~ ~~~~isuso 7 DR. C
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i 14. EFFECTS OF RAPID MASS IMMUNIZ
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Live Poliovirus Immunization-Condit
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Use of Sabin's Live Poliovirus Vacc
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- Use of Sabin's Live Poliovirus Va
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TABLE 14. Use of Sabin's Live Polio
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Discussion 411 DR. ANDERSON: My que
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Course of Mass Immunization in USSR
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, _ _ Course of Mass Immunization i
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DISCUSSION CHAIRMAN LÉPINE: Thank
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Discussion 431 DR. STUART-HARRIS: I
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436 Efficacy-Field Evidence TABLE 1
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438 Efficacy-Field Evidence Adminis
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444 Effcaey-Field Evidence 44 Efiay
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446 Efficacy-Field Evidence 446 Eff
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448 Efficacy-Field Evidence 448 lEf
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450 Efficacy-Field Evidence m Co 0
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452 Efficacy-Field Evidence ] ~~ ~
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454 Efficacy-Field Evidence It is n
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456 Efficacy-Field Evidence M.G. C
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460 460 Discussion Discussion~~~~~~
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462 Discussion one was sponsored by
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Vaccination with CHAT Strain Type 1
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Live Virus Vaccine Studies in South
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Discussion 481 the ages of the five
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Immunological and Epidemiological E
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DISCUSSION CHAIRMAN STUART-HARRIS:
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Further Observations on First Field
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Further Observations Qn First Field
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Further Observations on First FielJ
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Poliomyelitis Vaccination in Poland
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24. A SMALL-SCALE TRIAL WITH LIVE P
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Live Poliomyelitis Vaccine-Small-Sc
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25. VACCINATION AND CHALLENGE-POLIO
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Vaccination and Challenge-Poliomyel
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26. VACCINATION WITH ATTENUATED POL
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Vaccination with Attenuated Poliovi
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Discussion 575 ence last year. The
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Large-Scale Practical Trials, Use o
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594 Discussion 594 Disenísion ~ ~
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596 Discussion 596 Díscussion~~~~~
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598 Discussion 598 Discussion high
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602 Summary of the Conference 602 S
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Appendix The following letter was r
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608 Index Antibodies-continued half
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610 Index Bulychev, N. P., paper, 4
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612 Index Coxsackie--continued B-3
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614 Index Epidemics-continued intro
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616 Index Genetic stability-continu
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618 Index Infants-continued source
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620 Index Laboratory surveillance d
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622 Index Monkey neurovirulence, 95
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624 Index pH neutralization test, 6
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626 Index Poliomyelitis virus-conti
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628 Index Serological response-cont
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630 Index T marker-continued T- str
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632 Index Vaccine, Attenuated-conti
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634 Index Virus isolations and anti
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LIVE POLIO IRUS VACCINES

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