LIVE POLIO IRUS VACCINES

586
Efficacy-Field Evidence
immunization with vaccine in d-ragée form were
fully comparable to the response to immunization
with liquid live vaccine.
This has provided a basis, in 1960, for turning
to the large-scale use of dragées containing
live anti-poliomyelitis vaccine in carrying out
the program for mass vaccination of the population
up to 20 years of age.
The advantages of immunization with dragées
containing vaccine under conditions of mass
vaccination in the Soviet Union, lay in the fact
that the vaccine was received in ready-for-use
dragée form and there was no need to dilute
the vaccine at the vaccination center. Vaccination
by this means is also more attractive for
children and is easy to carry out not only for
medical workers in the medium and junior
grades but also for teachers in schools and
children's establishments. Vaccine in dragée
form can be distributed in a short period and
on a very large scale. Some further difficulties
in this matter, such as the need for the vaccine
dragées to be used quickly, to be stored at
refrigerator temperature and to be transported
Poliomyelitis in the Esthonian SSR
Reduction in the period June-December 1959 inclusive
0
40 -
Compared with the average over many years: 165:8=20.6
Compared with 1959 180:8=22.5
Compared with 1956 213:8=26.6
Compared with 1957 102:8=12.8
Compared with 1958 963:8=120.4
zZ
in containers cooled to 10 e C. proved fairly easy
to overcome. Vaccine in the forin of dragées is
more convenient in certain conditions than the
liquid live vaccine.
6. The Epidemiological Effectiveness of Mass
Iinmunization with Live Poliovirus Vaccine in
the Soviet Union According to the Data for
1959. In six republics of the Soviet Union;
Esthonia, Lithuania, Kazakhstan, Byelorussia,
Moldavia, and Latvia, and also in a number of
Oblasts in the RSFSR, three-stage immunization
with the live vaccine was carried out in
1959 before the beginning of the summer poliomyelitis
season, or in conditions favorable for
comparison of the morbidity rate among vaccinated
and unvaccinated persons. These observa-
60-
50-
30-
20-
10-
Oi
56 // /
57997 -
55-~ 2 2 1959 2
2 2 2~~~~~~~ O 0
_
Mos. VI VII Vlll IX X XI Xll
The vertical axis of the groph shows the
number of coases.
The horizontal axis shows the months from
June-December 1959.
The broken line is the average number of
cases over many years.
DIAGRAM 1. Poliomyelitis in the Esthonian SSR. Reduction in the number of cases in
1959 after immunization with the live vaccine.
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