LIVE POLIO IRUS VACCINES

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Page 23. Vaccination against Poliomyelitis in Poland with Koprowski's Live Attenuated Strains-F. Przesmycki, H. Dobrowolska, B. Mirski, R. Stanczyk, H. Wior, and A. Zaleska... . ..... .. .. ............................... ... 522 Discussion .................. .... ...... .. ..... 532 24. A Small-Scale Trial with Live Poliomyelitis Vaccine in an Isolated Island Community -N. Oker-Blom, Helena Strandstrom, and A. W. Eriksson .................. 533 25. Vaccination and Challenge-Poliomyelitis in Nicaragua, 1959-1960-Juan José Alcocer, Roberto Armijo, and Mauricio Martins da Silva ................... 547 26. Vaccination with Attenuated Polioviruses in Costa Rica-Second Progress Report. Section I. Vaccination Program-J. Núñez, O. Vargas-Méndez, E. C. Guevara, J. M. Quirce, J. A. Montoya, H. Doany, and M. Martins da Silva. Section II. Surveillance Program-J. M. Quirce, J. Núñez, E. C. Guevara, J. A. Montoya, H. Doany, and A. Shelokov . ................................. 561 Discussion ............... ...... . ..... ............................. 574 27. Large-Scale Practical Trials and Use of Live Poliovirus Vaccine in the USSR- V. M. Zhdanov, with the Participation of M. P. Chumakov and A. A. Smorodintsev. 576 NINTH SESSION, Friday, 10 June 1960, 2:00 p.m. Chairman: DR. OSCAR VARGAS-MÉNDEZ Discussion........ .......... ..................... ................ 591 Summary of the Conference ...... ................ 600 Appendix ......... . . ...... ... ......... ...... . 605 INDEX . .. . ..... ..... .. .......... 607 x
List of Participants Dr. E. Russell ALEXANDER Chief, Surveillance Section Epidemiology Branch Communicable Disease Center U.S. Public Health Service Atlanta, Georgia, U.S.A. Dr. Gaylord W. ANDERSON Director, School of Public Health University of Minnesota Minneapolis, Minnesota, U.S.A. Dr. Charles ARMSTRONG Medical Director (ret.), U.S. Public Health Service Laboratory of Infectious Diseases National Institutes of Health Bethesda, Maryland, U.S.A. Dr. Samuel BARON Division of Biologics Standards National Institutes of Health Bethesda, Maryland, U.S.A. Dr. Robert N. BARR Secretary and Executive Officer Minnesota State Board of Health Minnesota State Department of Health Minneapolis, Minnesota, U.S.A. Dr. Randolph BATSON Professor of Pediatrics Vanderbilt University School of Medicine Nashville, Tennessee, U.S.A. Dr. Henry BAUER Director, Division of Medical Laboratories Minnesota State Department of Health Minneapolis, Minnesota, U.S.A. Dr. Joseph A. BELL Chief, Epidemiological Section Laboratory of Infectious Diseases National Institute of Allergy and Infectious Diseases Bethesda, Maryland, U.S.A. xi Dr. Matilda BENYESH-MELNICK Assistant Professor of Virology and Epidemiology Baylor University College of Medicine Houston, Texas, U.S.A. Dr. David BODIAN Director, Department of Anatomy The Johns Hopkins University School of Medicine Baltimore, Maryland, U.S.A. Dr. Theodore E. BOYD Assistant Director of Research The National Foundation New York, N.Y., U.S.A. Dr. Samuel R. BOZEMAN Director, Biological Laboratories Pitman-Moore Company Indianapolis, Indiana, U.S.A. Sir F. Macfarlane BURNET Director, Walter and Eliza Hall Institute of Medical Research Melbourne, Australia Dr. Victor J. CABASSO Head, Virus Immunological Research Department Lederle Laboratories Pearl River, New York, U.S.A. Professor Mikhail P. CHUMAKOV Director, Institute for Poliomyelitis Research Academy of Medical Sciences Moscow, USSR Dr. Ernest T. CONYBEARE Principal Medical Officer Ministry of Health London, England
Page 1 and 2: LIVE POLIO IRUS VACCINES Papers Pre
Page 3 and 4: SECOND INTERNATIONAL CONFERENCE ON
Page 5: Preface The accumulation of informa
Page 8 and 9: Page Discussion .......... .......
Page 10 and 11: Page 6. Vaccination of Full-Term In
Page 14 and 15: Dr. Ghislain COURTOIS Director, Pri
Page 16 and 17: Dr. Edith PETTE Institute for the R
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Page 21 and 22: 4 Introductory Remarks 4 Introducto
Page 23 and 24: 6 General Considerations immunity a
Page 25 and 26: 8 General Considerations from accep
Page 27 and 28: 10 General Considerations 10 Genera
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Page 31 and 32: 14 Safety-Laboratory Evidence of At
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Page 49 and 50: 32 TABLE 1. Safety-Laboratory Evide
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46 Discussion a paralytic case. Thi
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48 Discussion + - + + I + - I + + 1
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50 Discussion sages of neurovirulen
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Application of Genetic Markers to D
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Discussion 67 TABLE 1. INCIDENCE OF
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Experimental Studies on Animals wit
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6. DETECTION OF A "NON-DETECTABLE"
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Detection of a "Non-Detectable" Sim
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Discussion 87 Dr. Koprowski's state
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Discussion 89 recognize its effects
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Laboratory Investigations of Attenu
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Discussion 99 In the case of Table
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8. BEHAVIOR OF COLD MUTANTS OF POLI
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Behavior of Cold Mutants of Poliovi
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DISCUSSION CHAIRMAN BURNET: Thank y
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114 Safety-Field Evidence of Safety
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118 S afety-Field Evidence of S af
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122 Discussion 122 Discussion~~~~~~
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10. LABORATORY INVESTIGATIONS OF TH
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126 VIRUS 1 MAhONEY Safety-Field Ev
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128 Safety-Field Evidence óf Safet
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DISCUSSION CHAIRMAN ZHDANOV: This p
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11. EPIDEMIOLOGICAL AND VIROLOGICAL
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12. SPREAD OF A VACCINE STRAIN OF P
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148 Saf ety-Field Evidence of Saf e
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152 Saf ety-Field Evidence of Safet
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DISCUSSION CHAIRMAN ZHDANOV: The pa
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158 Discussion 158 Díscussion~~~~~
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160 Discussion specimens. We were u
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. . . 168 Safety-Field Evidence of
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14. THE CAPACITY OF LIVE ATTENUATED
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176 Saf ety-Field Evidence of Saf e
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Field, Laboratory Experiences With
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16. STUDIES ON LIVE POLIOVIRUS VACC
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Studies on Live Poliovirus Vaccine
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Da. HORSTMANN: If I may answer for
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Discussion 205 Discussion 205 tried
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NOTE: The Spanish translation of th
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Vaccination of Pregnant Women and Y
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Development and Persistence of Poli
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Virologic, Serologic Investigations
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_ _ _ _ _ _ _ _ Virologic, Serologi
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cARE NUC:4I Discussion 267 CUAw # J
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Discussion 269 in the investigation
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Virological Findings, Antibody Resp
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4. ROUTINE IMMUNIZATION WITH ATTENU
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Routine Immunization With Attenuate
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Experimental Infectionwith CHATAtte
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Experimental Infection with CHATAtt
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Experimental Infection with CHATAtt
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Vaccination of Full-Term Infants wi
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Response of Newborn Infants to Vacc
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Susceptibility of Newborn Infants t
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9. IMMUNIZATION OF NEWBORN INFANTS
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Immunization of Newborn Infants wit
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Discussion 323 vaccinated siblings
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Discussion 325 Discussion 325 ance
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transplacental antibodies, or antib
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Discussion 329 Discussion 329 born
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Recent Experience with Lederle Triv
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11. FURTHER EXPERIENCES WITH ORAL P
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Further Experiences with Oral Polio
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Minnesota Studies with Oral Poliomy
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13. USE OF ATTENUATED LIVE POLIOVIR
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Use of Attenuated Live Poliovirus V
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Use of Attenuated Live Poliovirus V
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DISCUSSION CHAIRMAN LÉPINE: The tw
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Discussion 373 -~~~~~~ics o 7 domin
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Discussion 375 -~ ~~~~isuso 7 DR. C
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i 14. EFFECTS OF RAPID MASS IMMUNIZ
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Live Poliovirus Immunization-Condit
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Use of Sabin's Live Poliovirus Vacc
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- Use of Sabin's Live Poliovirus Va
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TABLE 14. Use of Sabin's Live Polio
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Discussion 411 DR. ANDERSON: My que
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Course of Mass Immunization in USSR
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, _ _ Course of Mass Immunization i
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DISCUSSION CHAIRMAN LÉPINE: Thank
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Discussion 431 DR. STUART-HARRIS: I
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436 Efficacy-Field Evidence TABLE 1
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438 Efficacy-Field Evidence Adminis
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444 Effcaey-Field Evidence 44 Efiay
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446 Efficacy-Field Evidence 446 Eff
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448 Efficacy-Field Evidence 448 lEf
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450 Efficacy-Field Evidence m Co 0
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452 Efficacy-Field Evidence ] ~~ ~
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454 Efficacy-Field Evidence It is n
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456 Efficacy-Field Evidence M.G. C
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460 460 Discussion Discussion~~~~~~
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462 Discussion one was sponsored by
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Vaccination with CHAT Strain Type 1
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Live Virus Vaccine Studies in South
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Discussion 481 the ages of the five
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Immunological and Epidemiological E
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DISCUSSION CHAIRMAN STUART-HARRIS:
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Further Observations on First Field
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Further Observations Qn First Field
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Further Observations on First FielJ
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Poliomyelitis Vaccination in Poland
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24. A SMALL-SCALE TRIAL WITH LIVE P
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Live Poliomyelitis Vaccine-Small-Sc
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25. VACCINATION AND CHALLENGE-POLIO
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Vaccination and Challenge-Poliomyel
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26. VACCINATION WITH ATTENUATED POL
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Vaccination with Attenuated Poliovi
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Discussion 575 ence last year. The
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Large-Scale Practical Trials, Use o
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594 Discussion 594 Disenísion ~ ~
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596 Discussion 596 Díscussion~~~~~
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598 Discussion 598 Discussion high
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iiiii iirrrimrmiriiiilllniririiiiii
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602 Summary of the Conference 602 S
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Appendix The following letter was r
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608 Index Antibodies-continued half
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610 Index Bulychev, N. P., paper, 4
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612 Index Coxsackie--continued B-3
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614 Index Epidemics-continued intro
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616 Index Genetic stability-continu
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618 Index Infants-continued source
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620 Index Laboratory surveillance d
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622 Index Monkey neurovirulence, 95
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624 Index pH neutralization test, 6
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626 Index Poliomyelitis virus-conti
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628 Index Serological response-cont
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630 Index T marker-continued T- str
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632 Index Vaccine, Attenuated-conti
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634 Index Virus isolations and anti
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LIVE POLIO IRUS VACCINES

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