LIVE POLIO IRUS VACCINES

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Capacity of Live Attenuated Polioviruses to Cause Human Infection 177 1! I C -,4 ÉlE-- N:$ 04T4 J-tA 4 ASUT 44 -E404E10F FIG. 4 _ Crac. _____ '--- `------· Ii IL ~~~~~~·i·i .·~~~~~~~~~~~~~·.·. ·~~~~~~~~~~~~-· r - y~~~~~~~~~~.% .......; D0TA J47Y 44764 S ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 6 , ~ - ,- FIG. 5
... ____ v __ _"_ _. ___.__ __ .,_.S. L _ ,_ ._____.._ _ ._._ _ 178 Safety-Field Evidence of Safety r-- .___--·- __ _.. E 0 +_-- 7;j LOST - . - -.. , -- .- - - -.4 ; ~ ~ . II .lHlll .... . . kgmm~ _ _ _.x r · --_. __ * - - ' } = ' = L Lr .__ _~ 7> ', 7· _. ' 7 oi- ' ,__ r===~ L ._ oi _ = . atGuSI 5FPtE98E'R ' 8: :: d'E2 & E5 Unidentified 7 E-12 ::-i:''S-: Cox 84 ooo. E-14 at E4 t E8 TYPE I __._ "Xt vac -_7 . _ _ 7 Pic. 6 ~"7 ~C SIBLIi4GS .., _ = . _ 7 7. __ . _ , _ _i ____ > _ $ _ ___ : i , = .__ _L__. _ 7 ~ ~ ~ ~ ~ ~ ~ - , ,,___ _._ _ _... 7. , __. ___,._..vo _ . 7 7._ _ . 1 20 .tRU S. .. P . 10 FAGUST FIG. 7 $EPTEMBE7
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LIVE POLIO IRUS VACCINES Papers Pre
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SECOND INTERNATIONAL CONFERENCE ON
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Preface The accumulation of informa
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Page Discussion .......... .......
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Page 6. Vaccination of Full-Term In
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Page 23. Vaccination against Poliom
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Dr. Ghislain COURTOIS Director, Pri
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Dr. Edith PETTE Institute for the R
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imimmmmmñimmimmm-ñmñmñrmimmimmm
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4 Introductory Remarks 4 Introducto
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6 General Considerations immunity a
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8 General Considerations from accep
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10 General Considerations 10 Genera
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14 Safety-Laboratory Evidence of At
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- 26 Safety-Laboratory Evidence of
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DISCUSSION CHAIRMAN ANDERSON: There
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30 Discussion CHAIRMAN ANDERSON: Th
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32 TABLE 1. Safety-Laboratory Evide
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40 Discussion Of the 22 monkeys inf
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DISCUSSION CHAIRMAN ANDERSON: Thank
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46 Discussion a paralytic case. Thi
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48 Discussion + - + + I + - I + + 1
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50 Discussion sages of neurovirulen
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Application of Genetic Markers to D
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Discussion 67 TABLE 1. INCIDENCE OF
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Experimental Studies on Animals wit
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6. DETECTION OF A "NON-DETECTABLE"
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Detection of a "Non-Detectable" Sim
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Discussion 87 Dr. Koprowski's state
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Discussion 89 recognize its effects
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Laboratory Investigations of Attenu
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Discussion 99 In the case of Table
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8. BEHAVIOR OF COLD MUTANTS OF POLI
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Behavior of Cold Mutants of Poliovi
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DISCUSSION CHAIRMAN BURNET: Thank y
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IULUUmmiillaYIIiiiiIllnllTrTnTnTm T
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114 Safety-Field Evidence of Safety
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118 S afety-Field Evidence of S af
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122 Discussion 122 Discussion~~~~~~
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10. LABORATORY INVESTIGATIONS OF TH
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Page 149 and 150: DISCUSSION CHAIRMAN ZHDANOV: This p
Page 151 and 152: 11. EPIDEMIOLOGICAL AND VIROLOGICAL
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Page 165 and 166: 148 Saf ety-Field Evidence of Saf e
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Page 173 and 174: DISCUSSION CHAIRMAN ZHDANOV: The pa
Page 175 and 176: 158 Discussion 158 Díscussion~~~~~
Page 177 and 178: 160 Discussion specimens. We were u
Page 185 and 186: . . . 168 Safety-Field Evidence of
Page 191 and 192: 14. THE CAPACITY OF LIVE ATTENUATED
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Page 206 and 207: Field, Laboratory Experiences With
Page 208 and 209: 16. STUDIES ON LIVE POLIOVIRUS VACC
Page 210 and 211: Studies on Live Poliovirus Vaccine
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Page 220 and 221: Da. HORSTMANN: If I may answer for
Page 222 and 223: Discussion 205 Discussion 205 tried
Page 224 and 225: NOTE: The Spanish translation of th
Page 226 and 227: Vaccination of Pregnant Women and Y
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Vaccination of Pregnant Women and Y
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Development and Persistence of Poli
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Virologic, Serologic Investigations
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_ _ _ _ _ _ _ _ Virologic, Serologi
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cARE NUC:4I Discussion 267 CUAw # J
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Discussion 269 in the investigation
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Virological Findings, Antibody Resp
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4. ROUTINE IMMUNIZATION WITH ATTENU
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Routine Immunization With Attenuate
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mmrriiiiiiiiiiiinniiiiiiiriiimmmmmn
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Experimental Infectionwith CHATAtte
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Experimental Infection with CHATAtt
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Experimental Infection with CHATAtt
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Vaccination of Full-Term Infants wi
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Response of Newborn Infants to Vacc
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Susceptibility of Newborn Infants t
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9. IMMUNIZATION OF NEWBORN INFANTS
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Immunization of Newborn Infants wit
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Discussion 323 vaccinated siblings
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Discussion 325 Discussion 325 ance
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transplacental antibodies, or antib
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Discussion 329 Discussion 329 born
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Recent Experience with Lederle Triv
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11. FURTHER EXPERIENCES WITH ORAL P
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Further Experiences with Oral Polio
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Minnesota Studies with Oral Poliomy
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13. USE OF ATTENUATED LIVE POLIOVIR
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Use of Attenuated Live Poliovirus V
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Use of Attenuated Live Poliovirus V
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DISCUSSION CHAIRMAN LÉPINE: The tw
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Discussion 373 -~~~~~~ics o 7 domin
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Discussion 375 -~ ~~~~isuso 7 DR. C
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i 14. EFFECTS OF RAPID MASS IMMUNIZ
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Live Poliovirus Immunization-Condit
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Use of Sabin's Live Poliovirus Vacc
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- Use of Sabin's Live Poliovirus Va
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TABLE 14. Use of Sabin's Live Polio
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Discussion 411 DR. ANDERSON: My que
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Course of Mass Immunization in USSR
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, _ _ Course of Mass Immunization i
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DISCUSSION CHAIRMAN LÉPINE: Thank
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Discussion 431 DR. STUART-HARRIS: I
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436 Efficacy-Field Evidence TABLE 1
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438 Efficacy-Field Evidence Adminis
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444 Effcaey-Field Evidence 44 Efiay
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446 Efficacy-Field Evidence 446 Eff
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448 Efficacy-Field Evidence 448 lEf
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450 Efficacy-Field Evidence m Co 0
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452 Efficacy-Field Evidence ] ~~ ~
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454 Efficacy-Field Evidence It is n
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456 Efficacy-Field Evidence M.G. C
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460 460 Discussion Discussion~~~~~~
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462 Discussion one was sponsored by
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Vaccination with CHAT Strain Type 1
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Live Virus Vaccine Studies in South
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Discussion 481 the ages of the five
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Immunological and Epidemiological E
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DISCUSSION CHAIRMAN STUART-HARRIS:
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Further Observations on First Field
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Further Observations Qn First Field
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Further Observations on First FielJ
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Poliomyelitis Vaccination in Poland
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24. A SMALL-SCALE TRIAL WITH LIVE P
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Live Poliomyelitis Vaccine-Small-Sc
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25. VACCINATION AND CHALLENGE-POLIO
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Vaccination and Challenge-Poliomyel
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26. VACCINATION WITH ATTENUATED POL
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Vaccination with Attenuated Poliovi
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Discussion 575 ence last year. The
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Large-Scale Practical Trials, Use o
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594 Discussion 594 Disenísion ~ ~
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596 Discussion 596 Díscussion~~~~~
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598 Discussion 598 Discussion high
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iiiii iirrrimrmiriiiilllniririiiiii
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602 Summary of the Conference 602 S
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Appendix The following letter was r
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608 Index Antibodies-continued half
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610 Index Bulychev, N. P., paper, 4
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612 Index Coxsackie--continued B-3
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614 Index Epidemics-continued intro
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616 Index Genetic stability-continu
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618 Index Infants-continued source
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620 Index Laboratory surveillance d
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622 Index Monkey neurovirulence, 95
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624 Index pH neutralization test, 6
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626 Index Poliomyelitis virus-conti
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628 Index Serological response-cont
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630 Index T marker-continued T- str
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632 Index Vaccine, Attenuated-conti
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634 Index Virus isolations and anti
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