LIVE POLIO IRUS VACCINES

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Vaccination of Pregnant Women and Young Inf ants with Trivalent Vaccine 223 ir u r r =; r z >1:1024 1:1024 1:512 1:256 1:128 1:64 1:32 1:16 1:4
224 Saf etv-Field Evidence of Saf ety TABLE 12. DISTRIBUTION OF TIME INTERVALS BETWEEN FEEDING AND LAST VIRUS ISOLATION FROM EIGHT INFANTS FED TRIVALENT ORAL LIVE ATTENUATED POLIOMYELITIS VACCINE* AT AGE 5-7 DAYS AND SEVEN INFANTS FED AT AGE 2-5 MONTHS NUMBER OF INFANTS (FED AGE 5-7 DAYS) NUMBER OF INFANTS (FED AGE 2-5 MONTHS) Ti T2 T, T2T 3 TT T 2 T2 T TT 0** 5 8 1 6 0 7 0 1 1 2 0 5 1 6 0 7 6 2 3 0 6 2 5 0 5 4 Time 3 3 0 3 1 5 0 4 2 in 4 1 0 1 0 3 0 5 2 Weeks 5 1 0 1 0 2 0 5 2 6 1 0 0 0 0 0 4 0 7 2 0 0 0 1 0 1 0 8 1 0 0 0 0 0 1 0 9 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 Total Infants 8 8 8 8 7 7 7 7 * 12 infants fed 1067' TCD 5 o each virus; 1 infant fed 106'7 TCDso each virus. * *Zero indicates no isolations. TABLE 13. VIRUS ISOLATION AMONG FAMILY CONTACTS OF SEVEN INFANTS FED TRIVALENT ORAL LIVE ATTENUATED POLIOMYELITIS VACCINE* Siblin Cont Lcts Virus Isolated Adult Contacts Virus Isolated Fed Age 5-7 Daye (5 Infants) T 1 T2 T 1 0 3 Totals 6 T 1 T 2 T 1 0 0 Totals 10 Fed Age 2-5 Months (2 Infants) 0 0 2 3 4 Totals 1 0 5 9 1 0 0 14 * 1061 TCDs 5 each virus. At least two changes are known to take place in the first four months of life that could explain this marked change in response to vaccination with attenuated oral polioviruses. Good 7 has shown that the newborn infant begins to produce gamma globulin at about age 40 days. This production increases rapidly until the infant is between 80- 120 days of age. At this age the gamma globulin level is within normal range and the full im- munologic capacity of the infant is nearly reached. The antibody titer passively transferred from mother to infant during intrauterine life declines rapidly after delivery and at age four months it is about one eighth (based on 37 day half-life) of the titer of the cord blood. This new ability of the infant to produce antibodies coupled with the gradual loss of the protective antibodies obtained from the mother makes the
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LIVE POLIO IRUS VACCINES Papers Pre
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SECOND INTERNATIONAL CONFERENCE ON
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Preface The accumulation of informa
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Page Discussion .......... .......
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Page 6. Vaccination of Full-Term In
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Page 23. Vaccination against Poliom
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Dr. Ghislain COURTOIS Director, Pri
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Dr. Edith PETTE Institute for the R
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4 Introductory Remarks 4 Introducto
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6 General Considerations immunity a
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8 General Considerations from accep
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10 General Considerations 10 Genera
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14 Safety-Laboratory Evidence of At
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- 26 Safety-Laboratory Evidence of
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DISCUSSION CHAIRMAN ANDERSON: There
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30 Discussion CHAIRMAN ANDERSON: Th
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32 TABLE 1. Safety-Laboratory Evide
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40 Discussion Of the 22 monkeys inf
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DISCUSSION CHAIRMAN ANDERSON: Thank
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46 Discussion a paralytic case. Thi
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48 Discussion + - + + I + - I + + 1
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50 Discussion sages of neurovirulen
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Application of Genetic Markers to D
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Discussion 67 TABLE 1. INCIDENCE OF
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Experimental Studies on Animals wit
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6. DETECTION OF A "NON-DETECTABLE"
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Detection of a "Non-Detectable" Sim
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Discussion 87 Dr. Koprowski's state
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Discussion 89 recognize its effects
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Laboratory Investigations of Attenu
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Discussion 99 In the case of Table
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8. BEHAVIOR OF COLD MUTANTS OF POLI
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Behavior of Cold Mutants of Poliovi
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DISCUSSION CHAIRMAN BURNET: Thank y
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114 Safety-Field Evidence of Safety
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118 S afety-Field Evidence of S af
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122 Discussion 122 Discussion~~~~~~
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10. LABORATORY INVESTIGATIONS OF TH
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126 VIRUS 1 MAhONEY Safety-Field Ev
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128 Safety-Field Evidence óf Safet
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DISCUSSION CHAIRMAN ZHDANOV: This p
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11. EPIDEMIOLOGICAL AND VIROLOGICAL
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12. SPREAD OF A VACCINE STRAIN OF P
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148 Saf ety-Field Evidence of Saf e
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152 Saf ety-Field Evidence of Safet
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DISCUSSION CHAIRMAN ZHDANOV: The pa
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158 Discussion 158 Díscussion~~~~~
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160 Discussion specimens. We were u
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. . . 168 Safety-Field Evidence of
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Page 206 and 207: Field, Laboratory Experiences With
Page 208 and 209: 16. STUDIES ON LIVE POLIOVIRUS VACC
Page 210 and 211: Studies on Live Poliovirus Vaccine
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Page 220 and 221: Da. HORSTMANN: If I may answer for
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Page 226 and 227: Vaccination of Pregnant Women and Y
Page 246 and 247: Development and Persistence of Poli
Page 258 and 259: Virologic, Serologic Investigations
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Page 288 and 289: Virological Findings, Antibody Resp
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Virological Findings, Antibody Resp
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Virological Findings, Antibody Resp
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4. ROUTINE IMMUNIZATION WITH ATTENU
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Routine Immunization With Attenuate
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Experimental Infectionwith CHATAtte
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Experimental Infection with CHATAtt
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Experimental Infection with CHATAtt
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Vaccination of Full-Term Infants wi
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Response of Newborn Infants to Vacc
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Susceptibility of Newborn Infants t
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9. IMMUNIZATION OF NEWBORN INFANTS
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Immunization of Newborn Infants wit
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Discussion 323 vaccinated siblings
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Discussion 325 Discussion 325 ance
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transplacental antibodies, or antib
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Discussion 329 Discussion 329 born
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Recent Experience with Lederle Triv
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11. FURTHER EXPERIENCES WITH ORAL P
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Further Experiences with Oral Polio
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Minnesota Studies with Oral Poliomy
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13. USE OF ATTENUATED LIVE POLIOVIR
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Use of Attenuated Live Poliovirus V
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Use of Attenuated Live Poliovirus V
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DISCUSSION CHAIRMAN LÉPINE: The tw
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Discussion 373 -~~~~~~ics o 7 domin
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Discussion 375 -~ ~~~~isuso 7 DR. C
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i 14. EFFECTS OF RAPID MASS IMMUNIZ
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Live Poliovirus Immunization-Condit
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Use of Sabin's Live Poliovirus Vacc
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- Use of Sabin's Live Poliovirus Va
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TABLE 14. Use of Sabin's Live Polio
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Discussion 411 DR. ANDERSON: My que
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Course of Mass Immunization in USSR
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, _ _ Course of Mass Immunization i
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DISCUSSION CHAIRMAN LÉPINE: Thank
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Discussion 431 DR. STUART-HARRIS: I
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436 Efficacy-Field Evidence TABLE 1
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438 Efficacy-Field Evidence Adminis
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444 Effcaey-Field Evidence 44 Efiay
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446 Efficacy-Field Evidence 446 Eff
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448 Efficacy-Field Evidence 448 lEf
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450 Efficacy-Field Evidence m Co 0
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452 Efficacy-Field Evidence ] ~~ ~
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454 Efficacy-Field Evidence It is n
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456 Efficacy-Field Evidence M.G. C
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460 460 Discussion Discussion~~~~~~
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462 Discussion one was sponsored by
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Vaccination with CHAT Strain Type 1
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Live Virus Vaccine Studies in South
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Discussion 481 the ages of the five
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Immunological and Epidemiological E
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DISCUSSION CHAIRMAN STUART-HARRIS:
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Further Observations on First Field
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Further Observations Qn First Field
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Further Observations on First FielJ
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Poliomyelitis Vaccination in Poland
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24. A SMALL-SCALE TRIAL WITH LIVE P
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Live Poliomyelitis Vaccine-Small-Sc
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25. VACCINATION AND CHALLENGE-POLIO
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Vaccination and Challenge-Poliomyel
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26. VACCINATION WITH ATTENUATED POL
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Vaccination with Attenuated Poliovi
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Discussion 575 ence last year. The
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Large-Scale Practical Trials, Use o
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594 Discussion 594 Disenísion ~ ~
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596 Discussion 596 Díscussion~~~~~
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598 Discussion 598 Discussion high
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602 Summary of the Conference 602 S
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Appendix The following letter was r
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608 Index Antibodies-continued half
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610 Index Bulychev, N. P., paper, 4
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612 Index Coxsackie--continued B-3
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614 Index Epidemics-continued intro
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616 Index Genetic stability-continu
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618 Index Infants-continued source
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620 Index Laboratory surveillance d
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622 Index Monkey neurovirulence, 95
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624 Index pH neutralization test, 6
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626 Index Poliomyelitis virus-conti
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628 Index Serological response-cont
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630 Index T marker-continued T- str
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632 Index Vaccine, Attenuated-conti
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634 Index Virus isolations and anti
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