INDEX Abad Gómez, Héctor, 369 Abortion, see Fetal loss "Acid barrier," see pH Acid media, see pH marker Adenoviruses in cold mutant study population, 107 isolated, Costa Rica, 575 isolation from monkey feces, 77 occurrence before vaccination, 537 proposed using HeLa cells to prepare live vaccine, 599 vaccine contaminated with Simian agents, 79, 85 Types 1-7 vacuolating virus contaminant, 80 Adsorption marker and covariation, 49 rate determination, 45 Africa, southern, field trial, 474-479 African green monkeys (Cercopithecus aethiops), see also Grivet, Vervet cytopathic changes by vacuolating agent, 79 from east Africa, 88 African swine fever tolerance study feasibility, 328 Agammaglobulinemia immunological anomalies, 461 Agar extract, M+ revertant, 199 Age conversion rate by types, 116 distribution of antibody, 253, 440 distribution of cases, 453, 466-467, 559 early immunization advised, 270 economic status, 158 infection, transmission, 188 intensity of contact infection, 485 of study population, 114 response, 247, 294, 336 spread, 7 susceptibility, 411 susceptibility of young adults, 461, 500 susceptibility under 5 years, 182 vaccine failures, 373 vaccinated groups, 242, 277, 389-390, 436-437, 548 Agol, V. I., 44 Ainbender, Eugene A., paper 41-43 Alajuela province, Costa Rica vaccination program, 1960, 563 Aland archipelago, Finland map, description, 533-534 Alaska, heterotypic response, 122 Alba, Rafael Alvarez see Alvarez Alba, Rafael Albania vaccine supplied by USSR, 419, 582 Alcocer, Juan José, paper 547-560; 532, 574 Alexander, E. Russell, 457 607 Alimentary tract immunologic resistance of cells, 414, 421, 585 infection and response failure, 148 infection in 50 Costa Rican families, 174 no antibodies despite infection, 232 vaccine stability after passage, 6 All-Union Scientific Conference on Live Vaccine countries represented, list, 581 Alma Ata, Kazakh SSR age-scope of program, 581 laboratory diagnosis substantiated, 420 Altamarino, Nympha, 226 Aluminum hydroxide gel suspensions adsorption and elution of Type 1 polio, 45 Alvarez, Manuel Ramos, see Ramos Alvarez, Manuel Alvarez Alba, Rafael, paper, 386-409 Alvarez Amézquita, J., paper, 377-385 American Public Health Association Meeting practicability of large-scale programs, 435 Amézquita, J. Alvarez, see Alvarez Amézquita. J. Ancienne Cité, Leopoldville, Congo number of vaccinee cases exceeded non-vaccinee cases, 466 Anderson, Gaylord W., 4, 28, 30, 39, 44, 45, 47, 49, 50, 371, 411, 459-461 Animal virulence correlation with human virulence, 444 Anthrax experimental method in chickens, 35 Antibodies abortive infection, 159 after fetal loss, 372 against vacuolating agent, 84-85 avidity, 268 development and persistence, 207, 228-239, 381, 417 distribution by age, 278 distribution in children, 281 dose relationship, 98 estimation and quality in evaluation, 121, 228, 238, 269, 373, 512 heterotypic appearance and persistence, 232, 235 standards for measurement, 602 Type 2 and 3 with Type 1 vaccination, 540 homotypic, 363 standards for measurement, 602 in children fed CHAT and Fox, 530 in human milk, 325 in infants, 218 in seronegatives, 348-349 low avidity and virus-antibody dissociation, 268 maternal antibodies and infant susceptibility, 306 and intestinal infection in vaccinated infant, 6, 288, 305, 308 effect on vaccination, 197, 219, 287, 294-295, 304, 326, 329
608 Index Antibodies-continued half-life analysis, 216-217, 282, 291, 294, 305, 317, 327 level in babies, 270, 287, 309, 315, 320-323, 339, 601 mask actively produced antibody, 317, 320, 328, 329 poliovirus and antibody response correlation, 207, 273, 292 naturally occurring, 537 need for multiple determinations, 59 pre-existing enterovirus infection, 122, 181 prevaccination, 115, 243, 278, 331, 336, 363, 378, 524, 564 pre- and postvaccination, 149, 252, 271, 347, 365, 395 production and virus multiplication, 6 protection against polio, 171, 411, 430 resistance of pharynx, 363 response to each immunotype, 208 Salk status, 169-171, 202, 337, 338, 443, 592 success of vaccination, 302, 322 test for, using radioactive polio, 267 viremia, 363 virus isolation, 350, 363 Type 1 high proportion of tested children, 479 increase in children under 10, 537 Type 2 half-life rate, 217 response is poor, 225 Type 3 circulation of, 432 estimated by immunoinactivation test, 230 Antibody determination method of comptuting, Karber, 230 patterns in Moscow and Karaganda regions, 242 pH and CP tests compared, 228, 316, 439 random sample of population, 438 radioactive virus on filter paper, new method, 266 technique, 68, 235, 359, 439 Antibody formation and virus concentrations, 76 cold mutants in children, 107 in 72% of children, 525 seldom produced after Sabin's Type 3, 78 trivalent vaccine to fill gaps, 375 Antibody level before and after vaccine, 282 during two-year observation, 322 heterotypic antibody response, 122 intestinal infection, 203 introduction of bias, 373 in vaccinated premature infants, 291 need for standardization, 156 optimal time for measuring, 156, 159 virus inhibition, 206 Antibody response, see also Booster effect age factor, 295, 300 analysis of patterns, 282, 295 assessment fourfold increase question, 371 correlation to dose and schedule, 221, 359, 362 Antibody response-continued defined, 158, 574 detection, 290 failure, 159, 290, 441 fourfold rise over maternal antibodies, 294 heterotypic and metabolic inhibition test, 532 conversion rate, bias introduced, 373 triple negative subjects, 238, 371 Type 1, not found, 122 Type 1 rise later than Type 2, 232 Type 2, 117, 322 Type 2 and 3 to Type 1 vaccination, 541 homotypic detected 7-14 days after feeding, 231 in children on Sottunga, 240, 426, 546 in immunes and non-immunes, 232 in infants, 194, 288, 304-306, 319-320, 329 in Minnesota spread study, 167 in vaccinees, 193 parallels field effectiveness, 439 poor with first feeding and booster, 212-213 pregnancy, 209-210 relation to virus excretion, 147, 320, 602 Salk's and Sabin's vaccine, compared, 205, 515 seronegative index, 252, 369 3 months after vaccination, 317, 585 trivalent vaccine, and monovalent, 345, 346 viral interference, 115, 176, 472 Antigenic differentiation test bottle number per dilution, 66 described, compared with CPE neutralization test, 160 mutations affecting a character, and plaque-size, 480 netutralization rate by homologous and beterologous antisera, 14 thliree to four-week interval for most accurate determination, 443 Antigenie relationship between polio types, 238 Arbor B viruses tolerance in mice, 328 Arizona Indian community Type 1, Sabin failed to spread, 144 Armenian SSR vaccination programs, 419, 582 Armijo, Roberto, paper, 547-560 Armstrong, Charles, 39, 463 Lansing virus in non-primate host, 5 Asano, Dr. -, 193 Ascaris lumbricoides, Cuban clhildrern infested, 368 Aseptic meningitis confused with non-paralytic polio, 458 incidence during trial, 454 T tests with wild polio, 23 Ashmarina, E. E., paper, 413-428; 416 Assael, Juan, 401 Atebrine treatment, for Giardia lamblia, 368 Attack rates by dose and socio-economic class Des Moines epidemic, 375 by race, 479 Costa Rica, 575
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LIVE POLIO IRUS VACCINES Papers Pre
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SECOND INTERNATIONAL CONFERENCE ON
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Preface The accumulation of informa
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Dr. Ghislain COURTOIS Director, Pri
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Dr. Edith PETTE Institute for the R
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30 Discussion CHAIRMAN ANDERSON: Th
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32 TABLE 1. Safety-Laboratory Evide
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40 Discussion Of the 22 monkeys inf
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42 Safety-Laboratory Evidence of At
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DISCUSSION CHAIRMAN ANDERSON: Thank
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46 Discussion a paralytic case. Thi
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48 Discussion + - + + I + - I + + 1
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50 Discussion sages of neurovirulen
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Application of Genetic Markers to D
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Application of Genetic Markers to D
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Application of Genetic Markers to D
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Application of Genetic Markers to D
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Application of Genetic Markers to D
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Application of Genetic Markers to D
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Discussion 67 TABLE 1. INCIDENCE OF
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Experimental Studies on Animals wit
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Experimental Studies on Animals wit
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Experimental Studies on Animals wit
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Experimental Studies on Animals wit
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Experimental Studies on Animals wit
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6. DETECTION OF A "NON-DETECTABLE"
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Detection of a "Non-Detectable" Sim
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Detection of a "Non-Detectable" Sim
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Detection of a "Non-Detectable" Sim
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Discussion 87 Dr. Koprowski's state
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Discussion 89 recognize its effects
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Laboratory Investigations of Attenu
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Laboratory Investigations of Attenu
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Laboratory Investigations of Attenu
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Laboratory Investigations of Attenu
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Discussion 99 In the case of Table
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8. BEHAVIOR OF COLD MUTANTS OF POLI
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Behavior of Cold Mutants of Poliovi
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Behavior of Cold Mutants of Poliovi
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Behavior of Cold Mutants of Poliovi
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DISCUSSION CHAIRMAN BURNET: Thank y
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114 Safety-Field Evidence of Safety
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116 Safety-Field Evidence of Safety
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118 S afety-Field Evidence of S af
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120 Safety-Field Evidence of Safety
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122 Discussion 122 Discussion~~~~~~
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10. LABORATORY INVESTIGATIONS OF TH
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126 VIRUS 1 MAhONEY Safety-Field Ev
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128 Safety-Field Evidence óf Safet
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130 Safety-Field Evidence of Safety
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DISCUSSION CHAIRMAN ZHDANOV: This p
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11. EPIDEMIOLOGICAL AND VIROLOGICAL
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136 Safety-Field Evidence of Safety
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138 Safety-Field Evidence of Safety
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140 Safety-Field Evidence of Safety
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142 Safety-Field Evidence of Safety
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12. SPREAD OF A VACCINE STRAIN OF P
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146 Safety-Field Evidence of Safety
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148 Saf ety-Field Evidence of Saf e
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150 Safety-Field Evidence of Safety
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152 Saf ety-Field Evidence of Safet
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154 Safety-Field Evidence of Safety
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DISCUSSION CHAIRMAN ZHDANOV: The pa
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158 Discussion 158 Díscussion~~~~~
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160 Discussion specimens. We were u
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162 Safety-Field Evidence of Safety
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164 Safety-Field Evidence of Safety
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166 Safety-Field Evidence of Safety
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. . . 168 Safety-Field Evidence of
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170 Safety-Field Evidence of Safety
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172 Safety-Field Evidence of Safety
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14. THE CAPACITY OF LIVE ATTENUATED
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176 Saf ety-Field Evidence of Saf e
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180 Safety-Field Evidence of Safety
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182 Safety-Field Evidence of Safety
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184 Safety-Field Evidence of Safety
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Field, Laboratory Experiences With
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16. STUDIES ON LIVE POLIOVIRUS VACC
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Studies on Live Poliovirus Vaccine
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Studies on Live Poliovirus Vaccine
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Studies on Live Poliovirus Vaccine
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Studies on Live Poliovirus Vaccine
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Da. HORSTMANN: If I may answer for
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Discussion 205 Discussion 205 tried
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NOTE: The Spanish translation of th
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Vaccination of Pregnant Women and Y
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Vaccination of Pregnant Women and Y
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Vaccination of Pregnant Women and Y
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Vaccination of Pregnant Women and Y
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Vaccination of Pregnant Women and Y
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Vaccination of Pregnant Women and Y
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Vaccination of Pregnant Women and Y
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Vaccination of Pregnant Women and Y
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Vaccination of Pregnant Women and Y
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Vaccination of Pregnant Women and Y
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Development and Persistence of Poli
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Development and Persistence of Poli
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Development and Persistence of Poli
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Development and Persistence of Poli
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Development and Persistence of Poli
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Development and Persistence of Poli
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Virologic, Serologic Investigations
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Virologic, Serologic Investigations
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Virologic, Serologic Investigations
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Virologic, Serologic Investigations
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Virologic, Serologic Investigations
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Virologic, Serologic Investigations
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Virologic, Serologic Investigations
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Virologic, Serologic Investigations
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Virologic, Serologic Investigations
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Virologic, Serologic Investigations
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Virologic, Serologic Investigations
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_ _ _ _ _ _ _ _ Virologic, Serologi
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Virologic, Serologic Investigations
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cARE NUC:4I Discussion 267 CUAw # J
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Discussion 269 in the investigation
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Virological Findings, Antibody Resp
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Virological Findings, Antibody Resp
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Virological Findings, Antibody Resp
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4. ROUTINE IMMUNIZATION WITH ATTENU
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Routine Immunization With Attenuate
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Routine Immunization With Attenuate
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Routine Immunization With Attenuate
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Experimental Infectionwith CHATAtte
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Experimental Infection with CHATAtt
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Experimental Infection with CHATAtt
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Vaccination of Full-Term Infants wi
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Vaccination of Full-Term Infants wi
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Vaccination of Full-Term Infants wi
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Vaccination of Full-Term Infants wi
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Response of Newborn Infants to Vacc
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Response of Newborn Infants to Vacc
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Response of Newborn Infants to Vacc
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Susceptibility of Newborn Infants t
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Susceptibility of Newborn Infants t
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Susceptibility of Newborn Infants t
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9. IMMUNIZATION OF NEWBORN INFANTS
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Immunization of Newborn Infants wit
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Immunization of Newborn Infants wit
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Discussion 323 vaccinated siblings
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Discussion 325 Discussion 325 ance
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transplacental antibodies, or antib
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Discussion 329 Discussion 329 born
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Recent Experience with Lederle Triv
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Recent Experience with Lederle Triv
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Recent Experience with Lederle Triv
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Recent Experience with Lederle Triv
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Recent Experience with Lederle Triv
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11. FURTHER EXPERIENCES WITH ORAL P
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Further Experiences with Oral Polio
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Further Experiences with Oral Polio
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Further Experiences with Oral Polio
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Further Experiences with Oral Polio
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Further Experiences with Oral Polio
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Further Experiences with Oral Polio
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Minnesota Studies with Oral Poliomy
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Minnesota Studies with Oral Poliomy
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Minnesota Studies with Oral Poliomy
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13. USE OF ATTENUATED LIVE POLIOVIR
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Use of Attenuated Live Poliovirus V
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Use of Attenuated Live Poliovirus V
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DISCUSSION CHAIRMAN LÉPINE: The tw
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Discussion 373 -~~~~~~ics o 7 domin
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Discussion 375 -~ ~~~~isuso 7 DR. C
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i 14. EFFECTS OF RAPID MASS IMMUNIZ
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Live Poliovirus Immunization-Condit
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Live Poliovirus Immunization-Condit
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Live Poliovirus Immunization-Condit
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Live Poliovirus Immunization-Condit
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Use of Sabin's Live Poliovirus Vacc
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Use of Sabin's Live Poliovirus Vacc
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Use of Sabin's Live Poliovirus Vacc
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- Use of Sabin's Live Poliovirus Va
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Use of Sabin's Live Poliovirus Vacc
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TABLE 14. Use of Sabin's Live Polio
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Use of Sabin's Live Poliovirus Vacc
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Use of Sabin's Live Poliovirus Vacc
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Use of Sabin's Live Poliovirus Vacc
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Use of Sabin's Live Poliovirus Vacc
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Use of Sabin's Live Poliovirus Vacc
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Use of Sabin's Live Poliovirus Vacc
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Discussion 411 DR. ANDERSON: My que
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Course of Mass Immunization in USSR
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Course of Mass Immunization in USSR
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Course of Mass Immunization in USSR
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Course of Mass Immunization in USSR
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, _ _ Course of Mass Immunization i
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Course of Mass Immunization in USSR
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Course of Mass Immunization in USSR
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DISCUSSION CHAIRMAN LÉPINE: Thank
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Discussion 431 DR. STUART-HARRIS: I
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436 Efficacy-Field Evidence TABLE 1
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438 Efficacy-Field Evidence Adminis
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440 Efficacy-Field Evidence TABLE 6
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442 Efficacy-Field Evidence TABLE 1
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444 Effcaey-Field Evidence 44 Efiay
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446 Efficacy-Field Evidence 446 Eff
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448 Efficacy-Field Evidence 448 lEf
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450 Efficacy-Field Evidence m Co 0
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452 Efficacy-Field Evidence ] ~~ ~
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454 Efficacy-Field Evidence It is n
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456 Efficacy-Field Evidence M.G. C
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458 Discussion 458 Discussion~~~~~~
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460 460 Discussion Discussion~~~~~~
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462 Discussion one was sponsored by
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464 Discussion 464 Discussion~~~~~~
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Vaccination with CHAT Strain Type 1
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Vaccination with CHAT Strain Type 1
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Vaccination with CHAT Strain Type 1
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Vaccination with CHAT Strain Type 1
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Live Virus Vaccine Studies in South
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Live Virus Vaccine Studies in South
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Live Virus Vaccine Studies in South
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Discussion 481 the ages of the five
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Immunological and Epidemiological E
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Immunological and Epidemiological E
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Immunological and Epidemiological E
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Immunological and Epidemiological E
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Immunological and Epidemiological E
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Immunological and Epidemiological E
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Immunological and Epidemiological E
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Immunological and Epidemiological E
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Immunological and Epidemiological E
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Immunological and Epidemiological E
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DISCUSSION CHAIRMAN STUART-HARRIS:
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Further Observations on First Field
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Further Observations Qn First Field
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Further Observations on First Field
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Further Observations on First FielJ
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Further Observations on First Field
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Further Observations on First Field
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Further Observations on First Field
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Poliomyelitis Vaccination in Poland
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Poliomyelitis Vaccination in Poland
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Poliomyelitis Vaccination in Poland
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Poliomyelitis Vaccination in Poland
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Poliomyelitis Vaccination in Poland
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24. A SMALL-SCALE TRIAL WITH LIVE P
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Live Poliomyelitis Vaccine-Small-Sc
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Live Poliomyelitis Vaccine-Small-Sc
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Live Poliomyelitis Vaccine-Small-Sc
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Live Poliomyelitis Vaccine-Small-Sc
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Live Poliomyelitis Vaccine-Small-Sc
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Live Poliomyelitis Vaccine-Small-Sc
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25. VACCINATION AND CHALLENGE-POLIO
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Vaccination and Challenge-Poliomyel
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Vaccination and Challenge-Poliomyel
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Vaccination and Challenge-Poliomyel
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