LIVE POLIO IRUS VACCINES

272
Efficacy-Laboratory Evidence
TABLE 1. VIROLOGICAL ISOLATIONS FROM IN-
FANTS, 3-4 MONTHS OF AGE, AFTER FEEDING
ORAL POLIOMYELITIS VACCINE
No PRE-FEEDING ENTEROVIRUSES FOUND
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Ti,,N, T 3 46 7/
T, o.v_ 6 9
T 3 oNv 9 /4
NON£ 4 6
* T = type.
rorc 65 /00
TABLE 2. IMMUNOLOGICAL RESPONSE OF IN-
FANTS, 3-4 MONTHS OF AGE, TO ORAL POLIO-
MYELITIS VACCINE
No PRE-FEEDING ENTEROVIRUSES FOUND
PO¿/ovI/~9O TYPt
,P OF' /NA NTvP
W/T# .}N T/B OD y
-REPPONP£d
P,'c¿wr
T, ANv T 3 42 68
Ti oNLV 6 9
T3 ow.v // /8
NONs 3 5
rTOTW¿ 62 /00
* T = type.
The corresponding immunological response is
summarized in Table 2. Again we find a high
per cent of the infants responding to poliovirus
Types 1 and 3, isolated from their stool specimens.
Considering response to single types, it is
seen that 77 per cent of the infants responded to
Type 1, and 86 per cent to Type 3.
Details of the immunological response are
illustrated in Fig. 1. Here are shown pre- and
post-feeding antibody titers to Types 1 and 3
poliovirus. The infants show comparatively high
titers in their post-feeding specimens, as compared
to their pre-feeding specimens. The anti-
body titers for Type 3 are somewhat higher than
those for Type 1 which may indicate that this
Type 3 poliovirus is a better antigen.
Correlation between the virological findings
and serological response are indicated in Table
3, which demonstrates almost complete correlation
between both methods of followup of the
poliomyelitis virus fed. Incomplete correlation
is noted in five children only. Three infants
who had excreted Type 3 poliovirus in their stool
specimens, showed antibody response to both
Type 3 and Type 1, while two other infants who
had excreted Types 1 and 3 simultaneously, re-
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