LIVE POLIO IRUS VACCINES

Further Observations on First Field Trial in Czechoslovakia
521
ADDENDUM
Finally, 1 should like to submit the following
recommendation to the leading officials of the
WHO: It is beyond doubt that not even for uswho
had at our disposal a well established network
of health services, virological laboratories
staffed with competent workers able to prepare
with all precautions a vaccine of such a degree
of safety, as rendered possible by all available
methods-was it an easy matter to decide on the
mass administration of such large amounts of a
live virus preparation to the entire population.
I think that it is not a problem of one country,
but a world-wide problem what sort of new
agents are administered to the population. I
recommend therefore the following concrete provisions:
1. That the WHO should establish a world
reference laboratory, responsible for the selection
and provision of tested virus strains, suitable
for the production of vaccine; and
2. That the WHO should, in collaboration
with governments of Member Countries, appoint
a certain small number of laboratories entitled
to prepare controlled live vaccine for certain
areas of the world.
Only then will it be possible to preventively
avoid possible damage and utilize fully the
advantages of the new prophylactic preparation
against the development of poliomyelitis epidemics.
REFERENCES
1. Skovránek, V., Zácek, K., et al.: Field trial
with Sabin's live poliovirus vaccine in Czechoslovakia,
1958-1959. In: Live Poliovirus Vaccines,
First International Conference. Scient.
Pub. no. 44 of the Pan American Health
Organization, pp. 530-571, 1959.
2. Zácek, K., Vonka, V., et al.: The state of
seroimmunity for poliomyelitis in Czechoslovakia.
J. Hyg. Epidem. (Praha) 2:423-
437, 1958.
3. Pesek, J.: Incidence of antibodies against
polioviruses in the population of Slovakia
prior to the 1957 vaccination scheme. J. Hyg.
Epidem. (Praha) 2:443-447, 1958.
4. Zácek, K., Vonka, V., and Adam, E.: The
antibody response in children vaccinated with
(a) live attenuated polioviruses and (b) the
fourth dose inactivated poliovaccine. Paper
presented at the International Epidemiological
Symposium, Prague, February 1960.
5. Burian, V., Vojtová, H., and Zácek, K.: The
spread of polioviruses in the population vaccinated
with live polioviruses in comparison
with the nonvaccinated population. Paper
presented at the International Epidemiological
Symposium, Prague, February 1960.