LIVE POLIO IRUS VACCINES

Immunization of Newborn Infants with Live Attenuated Poliovirus Vaccine 319
TABLE 5.
EVIDENCE OF ANTIBODY RESPONSE AT 3 MONTHS AFTER ADMINISTRATION OF LIVE POLIO-
VIRUS VACCINE TO NEWBORN INFANTS
EVIDENCE OF ANTIBODY RESPONSE
VACCINE FED
GROUP
NUMBER
PER CENT
Type
I
Only
1
2
3
4
5
5/22
6/16
7/21
6/19
10/31
23
37
33
32
32
I II III I II III
Types 6 1/20 7/20 2/20 5 35 10
I 7 2/24 14/24 2/24 8 58 8
+ 8 1/24 12/24 2/24 4 50 8
II
+ 9 2/20 8/20 3/20 10 40 15
III 10 2/27 8/27 5/27 7 30 18
None 11 0/19 0/19 0/19 0 0 0
Note: See Table 1 for key to groups.
TABLE 6. ORAL POLIOVIRUS VACCINATION OF NEWBORN INFANTS
Lack of effect of level of maternal antibody on poliovirus
multiplication in the intestinal tract
ANTIBODY TITER* NO. OF LOG 10 TCD50/GM. OF
OF CORD BLOOD INFANTS POLIOVIR1U S EXCRETED
< 16 7 3.7-6.2
32 8 2.7-5.2
64 22 1.9-5.7
128 13 1.4-5.7
256 11 2.0-4.7
512 5 3.2-6.0
1024 1 3.2
Reciprocal.