LIVE POLIO IRUS VACCINES

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Immunological and Epidemiological Effectiveness of Live Polio Vaccine 499 CID _] = C 00¡ I1I AD v-I 4 - IC -m = c·i = j= c III r- -~-l ci~~r ci cOijj i ¡- =c 'no N~l^l cicx rH * rSI I I I l ril ci9 t - =00 o cP ot - co -Ú t u: c O 00 X i C COcc C Ociq 0 2 ¡O)Oo 00 O~~i 2 2 c:i -c Nci U) C) 3 >) U) ; o W i~~c @ > Q; > °, c xc
500 Etfficacy-Field Evidence 500 Efficacy-Field Evidence~~~~~~~~~~~~~~~~~~~~~~~~~~ at intervals of four to six weeks. This schedule ensures two administrations of each virus serotype in the course of the triple immunization, is convenient in practice and is more effective, to judge from immunological findings, than the administration of monovalent vaccines if it is not followed by a fourth revaccination with trivaccine. 7. In 1960 the age groups to be immunized can be restricted to those up to 16-20 years, whose need for immunization is greater than that of the other age-groups. The comparatively rare cases of illness among older people are caused by infection with viruses circulating among children and young people. 8. The elimination of the main reservoir of the virus among children and young people up to 20 years of age will probably eliminate it among the older population in our country, who may be included in the immunization campaign at a later stage. BIBLIOGRAPHY 1. Bulichev, N. I., Groisman, G. M., Chalkina, O. M., Dyakova, V. S., Yezhov, N. N., Kovalev, A. A., Steklova, P. M., Sharapov, B. I., and Shlyakov, E. N.: Results of study of the epidemiological effectiveness of active immunization with live poliomyelitis vaccine in the Moldavian SSR. In: Live Poliomyelitis Vaccine, Leningrad, 1960. 2. Chumakov, M. P., et al.: Preliminary communication on the mass peroral immunization of the population against poliomyelitis with a live virus vaccine made from attenuated Sabin strains. Vopr. virus. 5: 520-533, 1959. 3. : Comparative description of the characteristics of the live poliomyelitis vaccine. Ibidem. 5: 533-537, 1959. 4. Davidenkova, Y. F. and Savelyeva-Vasilyeva, Y. A.: Results of two years' clinical observations of children immunized with the live attenuated vaccine against poliomyelitis. Zh. nevropat. psikhiat. 59: 790-795, 1959. 5. Drobyshevskaya, A. I., Klyuchareva, T. Y., Kolesnikov, L. V., and Smorodintsev, A. A.: The characteristics of the live vaccine used in 1959. In: Live Poliomyelitis Vaccine, Leningrad, 1960. 6. Gorev, N. Y.: The behavior of vaccinal strains of poliovirus in the intestinal canal of children vaccinated more than once. In: Live Poliomyelitis Vaccine, Leningrad, 1960. 7. Ilyenko, V. I. and Alekseyev, B. P.: The dynamics of poliovirus multiplication in the intestines of children vaccinated with the live attenuated vaccine. In: Live Poliomyelitis Vaccine, Leningrad, 1960. 8. , Kurnosova, L. M., Zhilova, G. P., and Radionova, R. N.: Material obtained from virological and serological examinations oi children in contact with children vaccinated with the live attenuated poliomyelitis vaccine. In: Live Poliomyelitis Vaccine, Leningrad, 1960. 9. Kantorovich, R. A., Zhilova, G. P., Ostrovski, G. D., Rykushina, B. P., Bregantseva, P. V., and Golubeva, L. P.: Experience in the mass immunization of the child population of the Pskov and Novgorod oblasts with live attenuated poliomyelitis vaccine. In: Live Poliomyelitis Vaccine, Leningrad, 1960. 10. Kardash, I. B., Votyakov, V. I., Ilyenko, V. I., Monakhova, O. I., Selivanov, Y. M., Feldman, E. V., Bondareva, N. V., Mar, G. 1., and Sheremetyeva, L. G.: Study of the epidemiological effectiveness of the live attenuated vaccine in the Byelorussian SSR. In: Live Poliomyelitis Vaccine, Leningrad, 1960. 11. Kosmachevski, V. V., Glaznova, G. S., and Aleksandrova, V. R.: Clinical observation of children of pre-school age after enteral vaccination with the live attenuated poliomyelitis vaccine. In: Live Poliomyelitis Vaccine, Leningrad, 1960. 12. Kurnosova, L. M. and Zhilova, G. P.: Immunological changes in the blood of children vaccinated with live poliomyelitis vaccine. In: Live Poliomyelitis Vaccine, Leningrad, 1960. 13. Smorodintsev, A. A.: The theoretical basis for the use of live poliomyelitis vaccine. In: Live Poliomyelitis Vaccine, Leningrad, 1960. 14. : Instructions on methods of organizing and carrying out peroral immunizaion with live attenuated poliomyelitis vaccine. Ibidem. 15. , et al.: Live poliomyelitis vac-
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LIVE POLIO IRUS VACCINES Papers Pre
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SECOND INTERNATIONAL CONFERENCE ON
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Preface The accumulation of informa
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Page Discussion .......... .......
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Page 6. Vaccination of Full-Term In
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Page 23. Vaccination against Poliom
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Dr. Ghislain COURTOIS Director, Pri
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Dr. Edith PETTE Institute for the R
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4 Introductory Remarks 4 Introducto
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6 General Considerations immunity a
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8 General Considerations from accep
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10 General Considerations 10 Genera
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14 Safety-Laboratory Evidence of At
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- 26 Safety-Laboratory Evidence of
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DISCUSSION CHAIRMAN ANDERSON: There
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30 Discussion CHAIRMAN ANDERSON: Th
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32 TABLE 1. Safety-Laboratory Evide
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40 Discussion Of the 22 monkeys inf
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DISCUSSION CHAIRMAN ANDERSON: Thank
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46 Discussion a paralytic case. Thi
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48 Discussion + - + + I + - I + + 1
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50 Discussion sages of neurovirulen
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Application of Genetic Markers to D
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Discussion 67 TABLE 1. INCIDENCE OF
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Experimental Studies on Animals wit
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6. DETECTION OF A "NON-DETECTABLE"
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Detection of a "Non-Detectable" Sim
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Discussion 87 Dr. Koprowski's state
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Discussion 89 recognize its effects
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Laboratory Investigations of Attenu
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Discussion 99 In the case of Table
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8. BEHAVIOR OF COLD MUTANTS OF POLI
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Behavior of Cold Mutants of Poliovi
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DISCUSSION CHAIRMAN BURNET: Thank y
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114 Safety-Field Evidence of Safety
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118 S afety-Field Evidence of S af
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122 Discussion 122 Discussion~~~~~~
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10. LABORATORY INVESTIGATIONS OF TH
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126 VIRUS 1 MAhONEY Safety-Field Ev
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128 Safety-Field Evidence óf Safet
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DISCUSSION CHAIRMAN ZHDANOV: This p
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11. EPIDEMIOLOGICAL AND VIROLOGICAL
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12. SPREAD OF A VACCINE STRAIN OF P
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148 Saf ety-Field Evidence of Saf e
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152 Saf ety-Field Evidence of Safet
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DISCUSSION CHAIRMAN ZHDANOV: The pa
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158 Discussion 158 Díscussion~~~~~
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160 Discussion specimens. We were u
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. . . 168 Safety-Field Evidence of
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14. THE CAPACITY OF LIVE ATTENUATED
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176 Saf ety-Field Evidence of Saf e
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Field, Laboratory Experiences With
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16. STUDIES ON LIVE POLIOVIRUS VACC
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Studies on Live Poliovirus Vaccine
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Da. HORSTMANN: If I may answer for
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Discussion 205 Discussion 205 tried
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NOTE: The Spanish translation of th
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Vaccination of Pregnant Women and Y
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Development and Persistence of Poli
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Virologic, Serologic Investigations
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_ _ _ _ _ _ _ _ Virologic, Serologi
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cARE NUC:4I Discussion 267 CUAw # J
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Discussion 269 in the investigation
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Virological Findings, Antibody Resp
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4. ROUTINE IMMUNIZATION WITH ATTENU
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Routine Immunization With Attenuate
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Experimental Infectionwith CHATAtte
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Experimental Infection with CHATAtt
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Experimental Infection with CHATAtt
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Vaccination of Full-Term Infants wi
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Response of Newborn Infants to Vacc
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Susceptibility of Newborn Infants t
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9. IMMUNIZATION OF NEWBORN INFANTS
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Immunization of Newborn Infants wit
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Discussion 323 vaccinated siblings
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Discussion 325 Discussion 325 ance
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transplacental antibodies, or antib
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Discussion 329 Discussion 329 born
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Recent Experience with Lederle Triv
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11. FURTHER EXPERIENCES WITH ORAL P
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Further Experiences with Oral Polio
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Minnesota Studies with Oral Poliomy
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13. USE OF ATTENUATED LIVE POLIOVIR
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Use of Attenuated Live Poliovirus V
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Use of Attenuated Live Poliovirus V
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DISCUSSION CHAIRMAN LÉPINE: The tw
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Discussion 373 -~~~~~~ics o 7 domin
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Discussion 375 -~ ~~~~isuso 7 DR. C
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i 14. EFFECTS OF RAPID MASS IMMUNIZ
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Live Poliovirus Immunization-Condit
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Use of Sabin's Live Poliovirus Vacc
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- Use of Sabin's Live Poliovirus Va
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TABLE 14. Use of Sabin's Live Polio
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Discussion 411 DR. ANDERSON: My que
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Course of Mass Immunization in USSR
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, _ _ Course of Mass Immunization i
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DISCUSSION CHAIRMAN LÉPINE: Thank
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Discussion 431 DR. STUART-HARRIS: I
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436 Efficacy-Field Evidence TABLE 1
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438 Efficacy-Field Evidence Adminis
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444 Effcaey-Field Evidence 44 Efiay
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446 Efficacy-Field Evidence 446 Eff
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Page 484 and 485: Vaccination with CHAT Strain Type 1
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Vaccination and Challenge-Poliomyel
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26. VACCINATION WITH ATTENUATED POL
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Vaccination with Attenuated Poliovi
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Discussion 575 ence last year. The
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Large-Scale Practical Trials, Use o
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592 Discussion 592 Discussion~~~~~~
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594 Discussion 594 Disenísion ~ ~
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596 Discussion 596 Díscussion~~~~~
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598 Discussion 598 Discussion high
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602 Summary of the Conference 602 S
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Appendix The following letter was r
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608 Index Antibodies-continued half
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610 Index Bulychev, N. P., paper, 4
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612 Index Coxsackie--continued B-3
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614 Index Epidemics-continued intro
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616 Index Genetic stability-continu
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618 Index Infants-continued source
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620 Index Laboratory surveillance d
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622 Index Monkey neurovirulence, 95
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624 Index pH neutralization test, 6
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626 Index Poliomyelitis virus-conti
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628 Index Serological response-cont
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630 Index T marker-continued T- str
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632 Index Vaccine, Attenuated-conti
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634 Index Virus isolations and anti
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