LIVE POLIO IRUS VACCINES

260
Efficacy-Laboratory Evidence
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BEFORE VACCINATION
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ONE MONTH AFTER SECOND FEEDING
WITH TRIVALENT VACCINE. JULY-AUGUST 1959
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TWO WEEKS AFTER ADDITIONAL FEEDING TWO WEEKS AFTER FEEDING WITH CANDIED
WITH CANDIED VACCINE TYPE 1. FEBRUARY 1960 TRIVALENT VACCINE. MARCH 1960
FIG. 8. Antibody patterns in children with antibody deficiency.
Children's Homes L. and R.
TABLE 25. ISOLATION OF ATTENUATED VIRUS OF POLIOMYELITIS TYPE 1 FROM CHILDREN (0-3 YRS.)
WITH CYTOPATHOGENIC AGENTS "CPA+-" AND WITHOUT CYTOPATHOGENIC AGENTS "CPA-" DURING
THE 14 DAYS AFTER IMMUNIZATION
1+2 WEEKS
3+4 WEEKS
CHILDREN
CPA-
CPA+
CPA-
CPA+
Investigated 107 70 107 70
Virus isolated 68 17 45 17
Per cent 63 24 41 24
nated with live trivalent vaccine from Sabin
strains are much lower, especially as regards
Types 1 and 3 viruses (Tables 25-28). At the
same time simultaneous multiplication of three
types of vaccine viruses and non-poliomyelitis
enteroviruses was observed, with development of
respective antibody (Figures 12 and 13).
Immunologic resistance of the intestinal tract
to Types 1 and 2 polioviruses develops one to
one and a half months after immunization with