LIVE POLIO IRUS VACCINES

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Vaccination with CHAT Strain Type 1 Polio Virus in Leopoldville 467 TABLE 1. POPULATION AND VACCINATION STATISTICS, LEOPOLDVILLE AFRICAN CHILDREN 6 MONTHS TO 2 YEARS OLD (IN THOUSANDS) AVERAGE POPULATION VACCINEES AREA OF CITY 1958 1959 30 APRIL 1959 30 APRIL 1960 Ancienne Cité Nouvelle Cité Five Districts 13.5 15.1 12.0 14.7 15.6 15.9 10.7 7.0 7.9 13.6 12.4 15.4 All 40.6 46.2 25.6 41.4 TABLE 2. REPORTED CASES OF PARALYTIC POLIOMYELITIS BY MONTH, JANUARY 1958 THROUGH APRIL 1960 AND BY VACCINATION STATUS Reported Cases Each Month: Vaccinated Cases in Parentheses YEAR JAN. FEB. MAR. APR. MAY JUNE JULY AUG. SEPT. OCT. NOV. DEC. 1958 1959 1960 12 5 6 1 2 0 1 0 1 (-)* (-) 24 15 9 1 5 6 10 9 7 (3) (2) (4) (-) (1) (1) (4) (5) (3) 4 (1) 6 (3) 6 3 (1) (-) 3 (-) 8 (4) 9 (1) 6 (3) 37 (-) 6 (3) * Vaccination began in August, 1958. TABLE 3. AGE DISTRIBUTION OF PARALYTIC POLIOMYELITIS IN AFRICAN CHILDREN, LEOPOLDVILLE, SINCE BEGINNING OF VACCINATION AGE IN YEARS AUG. '58-APR. '59 MAY '59- APR. '60 NUMBER PER CENT NUMBER PER CENT 3 25 57 15 1 1 25 58 15 1 1 3 14 37 16 4 2 4 18 49 21 5 3 Total 99 100 76 100 virus and also by the residential area and vaccination status of the individual from whom the virus was isolated. Seventeen Type 3 isolations were made during May to December 1959, as well as five Type l's, five Type 2's, and six nonpolio viruses. Fifteen viruses were isolated from vaccinated individuals, of which 10 were Type 3. Eighteen viruses were isolated from non-vaccinated individuals, of which seven were Type 3. From these data it is clear that there has been
468 Efficacy-Field Evidence TABLE 4. PARALYTIC POLIOMYELITIS IN AFRICAN CHILDREN BY GEOGRAPHIC AREA OF LEOPOLDVILLE AND VACCINATION STATUS AREA CASES VACCINATED NON-VACC. TOTAL Ancienne Cité 14 7 21 Nouvelle Cité 10 21 31 Five Districts 5 19 24 Total 29 47 76 TABLE 5. VIRUS ISOLATIONS FROM STOOLS IN PARALYTIC CASES, AUGUST 1958-DECEMBER 1959 POLIO 1 POLIO 2 POLIO 3 NON-POLIO 1958 Aug. Sept. Oct. Nov. Dec. 1959 Jan. Feb. Mar. Apr. May June July Aug. Sept. Oct. Nov. Dec. 1960 Jan. Feb. 1 1 6 6 5 2 2 2 1 1 1 1 1 3 1 1 1 2 1 6 2 2 1 1 2 1 1 2 1 TABLE 6. VIRUS ISOLATIONS FROM STOOLS IN PARALYTIC CASES AND VACCINATION STATUS ANALYZED BY LOCATION OF CASE AREA GROUP VIRUS ISOLATION TOTAL Ancienne Cité Nouvelle Cité Five Districts All Total Total Total Vacc. Non-Vacc. Total 2 3 1 4 5 3 2 2 3 5 6 3 8 10 7 17 1 3 2 2 4 6 10 10 13 15 18 33
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LIVE POLIO IRUS VACCINES Papers Pre
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SECOND INTERNATIONAL CONFERENCE ON
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Preface The accumulation of informa
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Page Discussion .......... .......
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Page 6. Vaccination of Full-Term In
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Page 23. Vaccination against Poliom
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Dr. Ghislain COURTOIS Director, Pri
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Dr. Edith PETTE Institute for the R
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4 Introductory Remarks 4 Introducto
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6 General Considerations immunity a
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8 General Considerations from accep
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10 General Considerations 10 Genera
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14 Safety-Laboratory Evidence of At
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- 26 Safety-Laboratory Evidence of
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DISCUSSION CHAIRMAN ANDERSON: There
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30 Discussion CHAIRMAN ANDERSON: Th
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32 TABLE 1. Safety-Laboratory Evide
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40 Discussion Of the 22 monkeys inf
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DISCUSSION CHAIRMAN ANDERSON: Thank
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46 Discussion a paralytic case. Thi
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48 Discussion + - + + I + - I + + 1
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50 Discussion sages of neurovirulen
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Application of Genetic Markers to D
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Discussion 67 TABLE 1. INCIDENCE OF
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Experimental Studies on Animals wit
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6. DETECTION OF A "NON-DETECTABLE"
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Detection of a "Non-Detectable" Sim
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Discussion 87 Dr. Koprowski's state
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Discussion 89 recognize its effects
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Laboratory Investigations of Attenu
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Discussion 99 In the case of Table
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8. BEHAVIOR OF COLD MUTANTS OF POLI
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Behavior of Cold Mutants of Poliovi
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DISCUSSION CHAIRMAN BURNET: Thank y
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114 Safety-Field Evidence of Safety
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118 S afety-Field Evidence of S af
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122 Discussion 122 Discussion~~~~~~
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10. LABORATORY INVESTIGATIONS OF TH
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126 VIRUS 1 MAhONEY Safety-Field Ev
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128 Safety-Field Evidence óf Safet
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DISCUSSION CHAIRMAN ZHDANOV: This p
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11. EPIDEMIOLOGICAL AND VIROLOGICAL
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12. SPREAD OF A VACCINE STRAIN OF P
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148 Saf ety-Field Evidence of Saf e
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152 Saf ety-Field Evidence of Safet
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DISCUSSION CHAIRMAN ZHDANOV: The pa
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158 Discussion 158 Díscussion~~~~~
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160 Discussion specimens. We were u
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. . . 168 Safety-Field Evidence of
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14. THE CAPACITY OF LIVE ATTENUATED
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176 Saf ety-Field Evidence of Saf e
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Field, Laboratory Experiences With
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16. STUDIES ON LIVE POLIOVIRUS VACC
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Studies on Live Poliovirus Vaccine
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Da. HORSTMANN: If I may answer for
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Discussion 205 Discussion 205 tried
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NOTE: The Spanish translation of th
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Vaccination of Pregnant Women and Y
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Development and Persistence of Poli
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Virologic, Serologic Investigations
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_ _ _ _ _ _ _ _ Virologic, Serologi
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cARE NUC:4I Discussion 267 CUAw # J
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Discussion 269 in the investigation
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Virological Findings, Antibody Resp
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4. ROUTINE IMMUNIZATION WITH ATTENU
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Routine Immunization With Attenuate
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Experimental Infectionwith CHATAtte
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Experimental Infection with CHATAtt
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Experimental Infection with CHATAtt
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Vaccination of Full-Term Infants wi
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Response of Newborn Infants to Vacc
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Susceptibility of Newborn Infants t
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9. IMMUNIZATION OF NEWBORN INFANTS
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Immunization of Newborn Infants wit
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Discussion 323 vaccinated siblings
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Discussion 325 Discussion 325 ance
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transplacental antibodies, or antib
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Discussion 329 Discussion 329 born
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Recent Experience with Lederle Triv
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11. FURTHER EXPERIENCES WITH ORAL P
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Further Experiences with Oral Polio
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Minnesota Studies with Oral Poliomy
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13. USE OF ATTENUATED LIVE POLIOVIR
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Use of Attenuated Live Poliovirus V
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Use of Attenuated Live Poliovirus V
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DISCUSSION CHAIRMAN LÉPINE: The tw
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Discussion 373 -~~~~~~ics o 7 domin
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Discussion 375 -~ ~~~~isuso 7 DR. C
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i 14. EFFECTS OF RAPID MASS IMMUNIZ
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Live Poliovirus Immunization-Condit
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Use of Sabin's Live Poliovirus Vacc
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- Use of Sabin's Live Poliovirus Va
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TABLE 14. Use of Sabin's Live Polio
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Discussion 411 DR. ANDERSON: My que
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Page 486 and 487: Vaccination with CHAT Strain Type 1
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Further Observations on First Field
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Poliomyelitis Vaccination in Poland
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24. A SMALL-SCALE TRIAL WITH LIVE P
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Live Poliomyelitis Vaccine-Small-Sc
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25. VACCINATION AND CHALLENGE-POLIO
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Vaccination and Challenge-Poliomyel
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26. VACCINATION WITH ATTENUATED POL
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Vaccination with Attenuated Poliovi
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Discussion 575 ence last year. The
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Large-Scale Practical Trials, Use o
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592 Discussion 592 Discussion~~~~~~
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594 Discussion 594 Disenísion ~ ~
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596 Discussion 596 Díscussion~~~~~
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598 Discussion 598 Discussion high
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602 Summary of the Conference 602 S
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Appendix The following letter was r
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608 Index Antibodies-continued half
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610 Index Bulychev, N. P., paper, 4
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612 Index Coxsackie--continued B-3
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614 Index Epidemics-continued intro
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616 Index Genetic stability-continu
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618 Index Infants-continued source
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620 Index Laboratory surveillance d
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622 Index Monkey neurovirulence, 95
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624 Index pH neutralization test, 6
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626 Index Poliomyelitis virus-conti
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628 Index Serological response-cont
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630 Index T marker-continued T- str
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632 Index Vaccine, Attenuated-conti
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634 Index Virus isolations and anti
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LIVE POLIO IRUS VACCINES

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