LIVE POLIO IRUS VACCINES

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Minnesota Studies with Oral Poliomyelitis Vaccines 363 TABLE 7. SUMMARY OF LABORATORY RESULTS OBTAINED IN THE 8 PERSONS IN WHOM VIREMIA WAS DEMONSTRATED. A TOTAL OF 95 PERSONS TESTED DAY OF SPECNIEN SPEC1- MEN NUM- BER PREVACCINE ANTIBODY TITEB < II III LATED FnOM SEIUM SIZE OF INOCULUM AND RESULTS 3 0.2 1 2.0 ml ml 0.2 ml 2.0 ml 7 0.2 2.0 ml ml POSTVACCINE ANTIBODY TITER I II III POLIO TYPE Iso- PHARYN- OEAL Is80oLATE TYPES STOoL Iso- LATION TYPES DosE FORNM TIME OF DOSE 411 444
364 Efficacy-Laboratory Evidence TABLE 8. VIREMIA IN RELATION TO PREVACCINE ANTIBODY STATUS ANTIBODY TITER TYPE I LEss THAN 4, NUMBER VIRUS RATIO BY TYPES OF PERSONS ISOLATED ANTIBODY TITER TYPE III LEss THAN 4, NUMlBER VIRUS RATIO BY TYPEs OF PERSONS ISOLATED I, II, and III 5 4 1:1.25 I and II 9 2 1:4.5 I and III I 10 1 1:10 TOTAL 24 7 1: 3.4 I, II, and III 5 0 0 I and III 11 0 0 II and III III 28 1 1: 28 TOTAL 44 1 1:44 or perhaps whole laked blood could be used as inocula, a larger number of virus isolations would have been accomplished. No clinical evidence of illness was present at the time of viremia in the eight people from whose blood serum virus was isolated. It is of interest that Type 1 poliovirus was isolated from seven persons and Type 3 virus was isolated only once. In no instance was Type 2 poliovirus isolated from the blood. Whether this represents a strain difference or a type difference remains to be studied. Approximately one and three quarter million people have ingested the oral poliomyelitis vaccine virus strains reported in this study. On the basis of the data presented, it is reasonable to suppose that thousands of persons who have ingested the vaccine have had a viremia with one or perhaps more of the vaccine virus types, yet illnesses among these vaccinees which can be causally associated with the vaccine, if any, have not been proven. REFERENCE 1. Barr, Robert N., Bauer, Henry, Kleinman, Herman, Johnson, Eugene A., Martins da Silva, Mauricio, Kimball, Anne C., and Cooney, Marion K.: Use of orally administered live attenuated polioviruses as a vaccine in a community setting: A controlled study. J. Am. M. Assn. 170: 893-905 (June 20) 1959.
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LIVE POLIO IRUS VACCINES Papers Pre
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SECOND INTERNATIONAL CONFERENCE ON
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Preface The accumulation of informa
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Page Discussion .......... .......
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Page 6. Vaccination of Full-Term In
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Page 23. Vaccination against Poliom
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Dr. Ghislain COURTOIS Director, Pri
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Dr. Edith PETTE Institute for the R
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4 Introductory Remarks 4 Introducto
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6 General Considerations immunity a
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8 General Considerations from accep
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10 General Considerations 10 Genera
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14 Safety-Laboratory Evidence of At
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- 26 Safety-Laboratory Evidence of
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DISCUSSION CHAIRMAN ANDERSON: There
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30 Discussion CHAIRMAN ANDERSON: Th
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32 TABLE 1. Safety-Laboratory Evide
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40 Discussion Of the 22 monkeys inf
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DISCUSSION CHAIRMAN ANDERSON: Thank
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46 Discussion a paralytic case. Thi
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48 Discussion + - + + I + - I + + 1
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50 Discussion sages of neurovirulen
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Application of Genetic Markers to D
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Discussion 67 TABLE 1. INCIDENCE OF
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Experimental Studies on Animals wit
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6. DETECTION OF A "NON-DETECTABLE"
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Detection of a "Non-Detectable" Sim
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Discussion 87 Dr. Koprowski's state
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Discussion 89 recognize its effects
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Laboratory Investigations of Attenu
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Discussion 99 In the case of Table
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8. BEHAVIOR OF COLD MUTANTS OF POLI
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Behavior of Cold Mutants of Poliovi
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DISCUSSION CHAIRMAN BURNET: Thank y
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114 Safety-Field Evidence of Safety
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118 S afety-Field Evidence of S af
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122 Discussion 122 Discussion~~~~~~
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10. LABORATORY INVESTIGATIONS OF TH
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126 VIRUS 1 MAhONEY Safety-Field Ev
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128 Safety-Field Evidence óf Safet
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DISCUSSION CHAIRMAN ZHDANOV: This p
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11. EPIDEMIOLOGICAL AND VIROLOGICAL
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12. SPREAD OF A VACCINE STRAIN OF P
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148 Saf ety-Field Evidence of Saf e
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152 Saf ety-Field Evidence of Safet
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DISCUSSION CHAIRMAN ZHDANOV: The pa
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158 Discussion 158 Díscussion~~~~~
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160 Discussion specimens. We were u
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. . . 168 Safety-Field Evidence of
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14. THE CAPACITY OF LIVE ATTENUATED
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176 Saf ety-Field Evidence of Saf e
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Field, Laboratory Experiences With
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16. STUDIES ON LIVE POLIOVIRUS VACC
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Studies on Live Poliovirus Vaccine
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Da. HORSTMANN: If I may answer for
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Discussion 205 Discussion 205 tried
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NOTE: The Spanish translation of th
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Vaccination of Pregnant Women and Y
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Development and Persistence of Poli
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Virologic, Serologic Investigations
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_ _ _ _ _ _ _ _ Virologic, Serologi
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cARE NUC:4I Discussion 267 CUAw # J
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Discussion 269 in the investigation
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Virological Findings, Antibody Resp
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4. ROUTINE IMMUNIZATION WITH ATTENU
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Routine Immunization With Attenuate
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Experimental Infectionwith CHATAtte
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Experimental Infection with CHATAtt
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Experimental Infection with CHATAtt
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Vaccination of Full-Term Infants wi
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Response of Newborn Infants to Vacc
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Susceptibility of Newborn Infants t
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Susceptibility of Newborn Infants t
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Page 360 and 361: Further Experiences with Oral Polio
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Page 376 and 377: Minnesota Studies with Oral Poliomy
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Page 384 and 385: Use of Attenuated Live Poliovirus V
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Course of Mass Immunization in USSR
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, _ _ Course of Mass Immunization i
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DISCUSSION CHAIRMAN LÉPINE: Thank
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Discussion 431 DR. STUART-HARRIS: I
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436 Efficacy-Field Evidence TABLE 1
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438 Efficacy-Field Evidence Adminis
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444 Effcaey-Field Evidence 44 Efiay
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446 Efficacy-Field Evidence 446 Eff
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448 Efficacy-Field Evidence 448 lEf
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450 Efficacy-Field Evidence m Co 0
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452 Efficacy-Field Evidence ] ~~ ~
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454 Efficacy-Field Evidence It is n
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456 Efficacy-Field Evidence M.G. C
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460 460 Discussion Discussion~~~~~~
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462 Discussion one was sponsored by
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Vaccination with CHAT Strain Type 1
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Live Virus Vaccine Studies in South
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Discussion 481 the ages of the five
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Immunological and Epidemiological E
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DISCUSSION CHAIRMAN STUART-HARRIS:
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Further Observations on First Field
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Further Observations Qn First Field
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Further Observations on First FielJ
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Poliomyelitis Vaccination in Poland
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24. A SMALL-SCALE TRIAL WITH LIVE P
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Live Poliomyelitis Vaccine-Small-Sc
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25. VACCINATION AND CHALLENGE-POLIO
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Vaccination and Challenge-Poliomyel
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26. VACCINATION WITH ATTENUATED POL
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Vaccination with Attenuated Poliovi
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Discussion 575 ence last year. The
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Large-Scale Practical Trials, Use o
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594 Discussion 594 Disenísion ~ ~
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596 Discussion 596 Díscussion~~~~~
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598 Discussion 598 Discussion high
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602 Summary of the Conference 602 S
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Appendix The following letter was r
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608 Index Antibodies-continued half
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610 Index Bulychev, N. P., paper, 4
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612 Index Coxsackie--continued B-3
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614 Index Epidemics-continued intro
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616 Index Genetic stability-continu
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618 Index Infants-continued source
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620 Index Laboratory surveillance d
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622 Index Monkey neurovirulence, 95
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624 Index pH neutralization test, 6
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626 Index Poliomyelitis virus-conti
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628 Index Serological response-cont
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630 Index T marker-continued T- str
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632 Index Vaccine, Attenuated-conti
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634 Index Virus isolations and anti
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