LIVE POLIO IRUS VACCINES

Index
617
Human tissue-culture systems
cytopathogenic effect-method, 394
differential growth compared to monkey tissue, 7
in rabbit immune serum, 80
Human milk, see Milk, human
Hummeler, Klaus, 279
Humoral immunity
and resistance of CNS, 482
and resistance of intestinal tract, 485
appearance and duration, 298, 585
evaluation of results, 489
Type 3 compared to Types 1 and 2, 483
Hungary
epidemic, 1959, 518, 576, 579
more than 2.5 million children vaccinated, 419
vaccine supplied by USSR, 419, 582
Hussey, Hugh H., 4
Hygienic conditions
contact infection and primitive sanitary conditions,
485
Hyogo prefecture, Japan
field trial, 193
IBM punch cards
data processing, 446
Icebergs
and polio compared, 578
Identification, see Markers
Illnesses
and vaccination, 465
Ilyenko, V. I., paper, 482-501
Immunity, see also Antibodies, Humoral immunity
and virus-antibody-cell interaction, 238
children infected transiently, 6
duration of, 313, 339, 482, 542
effect of vaccination schedules, 541
entire population by age 4, 410
following subelinical infection, 191
in children with no Salk vaccine, 591
maintenance in community, 308
Mauritius, 1955, 475
pre- and postvaccination, 478
prevaccination determined, 534, 536, 568
Rodrigues 1957, 1959, 478
serological evidence following infection, 5
seronegative index a measure of, 211, 367, 369
surveys, southern Africa, 474
Immunization
and massive enteric infection, 377-385
blind, low expectation, 505
circulating antibodies do not interfere, 6
extent and decline of cases, 505
failure, reasons, 401
latent, by contact transmission, 585
mass and simultaneous, 414
natural, in Cuban children, 367
need for compulsory, 496
newborn infants, 223, 315-321
practical public-health measure, 282
prevaccination status of population, 446
Immunization program, see Field trials
Immunizing agent
killed vaccines should have 10 s virus particles, 374
Immunoinactivation test, 53, 230
compared, CPE and pH test, 231
modification, 287
Immunogenic properties
antibody conversion rate, children, 394
high degree of live vaccine, 493
in negative children fed booster, 384
of Sabin strains, 400, 482
two feedings without paralysis, 384
"Immunologic dystonia"
due to interference between polio types, 413
Immunologic response
and ecological differences, 463
and immunization schedule, 484
and susceptibility of bowel, 302
correlation with internal control, 506
infants, 6, 224, 272, 296, 300
poor for Type 3, 197
pregnant women, 207
rarely induced from contact, 144
resistance developed without antibody production,
262
Sabin strains comparable to Salk, 420, 585
to heterotypic poliovirus, 232, 235
tolerance in infection, 328
Inactivated vaccine, see Vaccine, Killed (Salk)
Inactivation kinetics
for vacuolating virus with formalin, 84
Incidence,
by place
Byelorussia, 496
Dade County, Florida, 457
Mexico, 1955-1960, 396-397
Netherlands, 134
Slovakia, 1960, 532
United States, 1959, 330
effectiveness of vaccination, 486
polio and enteroviruses compared, 380
reduction among inoculated, 493
three times as great after vaccination, 518
virologically confirmed poliovirus infections, 139
Inclán, Samuel, 401
Incubation period
prolongation, and antibody titer, CPE and pH
tests, 230
Incubator
fluctuations and T marker, 132
Index child
playmate infection, 183
spread, twins, 202
India
smallpox study, 598
India ink
in inoculation of lumbar cord, 71-72
Infant home, Tokyo
isolation of Type 2 polio, 191
Infants
breast or bottle-fed, 324
feeding technique, 418
premature and vaccination, 287-293, 294
residual maternal antibody, 217
response to killed and live vaccines, 304-306, 328-
329, 568