LIVE POLIO IRUS VACCINES

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Development and Persistence of Polio Antibodies in Young Adults 233 TABLE 3. THE VIRUS EXCRETION IN STOOLS OF 22 INDIVIDUALS AGED 15-18 FED WITH 100,000 OF TYPE 3 ATTENUATED POLIOVIRUS No. CASE pH/1 ANTI- BODIES BEFORE VACCINATION LOGio OF VIRUS PER GRAM OF STOOL No. OF DAYS AFTER FEEDING OF VIRUS 1 2 3 o 4 7 10 14 21 28 1 35 1 42 1 F. 1/HB 18 + 2, 5 2, 5 2 CH. 2/HB 18 + 2, 5 5, 5 2, 5 3, 5 4, 5 4, 0 3 D. 3/HB 18 + 4 5 6 7 H. 4/HB V. 5/HB S. 6/HB K. 7/HB 18 18 18 18 + q- _ + + + 4, 0 2, 5 4, 5 2, 5 __ -- tr 3, 5 trt) 8 Z. 8/HB 18 + 5, 5*) 9 P. 9/HB 18 -- + + 2, 5 2, 5 10 11 K.10/HB Z.11/HB 17 17 + - + + 3, 5 5, 5 5, 5 3, 5 3, 5 5, 5 3, 0 3, 5 4, 0 tr tr 13 14 S.15/HB H.16/HB P.17/HB 18 17 16 + + + q- + 4, 5 2, 5 5, 5 5, 0 3, 5 3, 5 3, 5 3, 5 3, 5 15 16 S.]8/HB S.20/HB 16 16 + q- + 3, 5 tr 5, 0 4, 5 5, 0 17 18 19 K.21/HB F.22/HB S.23/HB 18 15 15 + + + + + + tr 3, 5 5, 0 3, 5 3, 0 3, 5 3, 5 2, 5 3, 5 20 J.25/H13 18 q- 3, 5 21 26/HB 18 +- tr ¡ tr 4, 5 22 M.27/HB 18 + ? Traces of virus in stool. * In this one case Type 2 virus was isolated. NOTE: The antibodies were estimated in pH test with one-hour incubation of the virus-serum mixture at room temperature.
234 Efficacy-Laboratory Evidence 40961 20481 /HO 9/HO 1024 Sf2 64 25/1B f288 8 16- 4 102Cq ¡>, / .. f 4 10 21 28 35 42 84 - CPT vith ir iur¢ution - pHT -- ..--... CPT vith 6 nruboin ---- pHT -n- - lit Viru in reol ..* --- a 024r 4 2 2 3 42 7 14'7 - FIG. 4. The development of Type 3 antibody measured by different neutralization tests in young adults with preexisting serological immunity, fed with 100,000 TCD 5 o of Type 3 attenuated virus. Day of sompling 7 21 35 s SPI 0 14 28 42 84 1 - 3 + '. . . . ' 1 + 2/1HB2 3 - - Doy of sompling 7 21 35 - SP o , 14 28 42 84 1 - 1OIH82 - a 3 - 1 + IIIHB2 3 + - Doy of sompling ~- 7PI 21 35 i-SPI 0 14 28, 42 84 1 - 201HB2 + 3 + 221HB2 3 4. 4. + 1 + 1 + 4/HB2 + 16/HB2 + 3 - 3 - 1 + 7/HB2 3 - + a a 1 + 17/1HB2 + 3 + m 1+ 23/HB2 3 1 - 251HB2 + 3 + 1 + 91HB2 + 3 + 1 I 1 - 181HB2 - _ 26/HB2 + 3 - 3 - SPI-state of preexisting immunity _ oppearance of ontibodies detected in pHI/6 or more tests or significont ontibody rise in CP/1 or pil +* pl/6 or pH/6+CP/6 or more tests i disappeorance of ontibodies or dicrease of antibody titre to the preimmunization level i i ontibodies detected only in pH/6 in the titre 4:4 Fic. 5 u
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LIVE POLIO IRUS VACCINES Papers Pre
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SECOND INTERNATIONAL CONFERENCE ON
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Preface The accumulation of informa
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Page Discussion .......... .......
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Page 6. Vaccination of Full-Term In
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Page 23. Vaccination against Poliom
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Dr. Ghislain COURTOIS Director, Pri
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Dr. Edith PETTE Institute for the R
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4 Introductory Remarks 4 Introducto
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6 General Considerations immunity a
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8 General Considerations from accep
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10 General Considerations 10 Genera
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14 Safety-Laboratory Evidence of At
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- 26 Safety-Laboratory Evidence of
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DISCUSSION CHAIRMAN ANDERSON: There
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30 Discussion CHAIRMAN ANDERSON: Th
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32 TABLE 1. Safety-Laboratory Evide
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40 Discussion Of the 22 monkeys inf
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DISCUSSION CHAIRMAN ANDERSON: Thank
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46 Discussion a paralytic case. Thi
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48 Discussion + - + + I + - I + + 1
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50 Discussion sages of neurovirulen
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Application of Genetic Markers to D
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Discussion 67 TABLE 1. INCIDENCE OF
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Experimental Studies on Animals wit
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6. DETECTION OF A "NON-DETECTABLE"
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Detection of a "Non-Detectable" Sim
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Discussion 87 Dr. Koprowski's state
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Discussion 89 recognize its effects
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Laboratory Investigations of Attenu
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Discussion 99 In the case of Table
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8. BEHAVIOR OF COLD MUTANTS OF POLI
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Behavior of Cold Mutants of Poliovi
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DISCUSSION CHAIRMAN BURNET: Thank y
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114 Safety-Field Evidence of Safety
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118 S afety-Field Evidence of S af
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122 Discussion 122 Discussion~~~~~~
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10. LABORATORY INVESTIGATIONS OF TH
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126 VIRUS 1 MAhONEY Safety-Field Ev
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128 Safety-Field Evidence óf Safet
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DISCUSSION CHAIRMAN ZHDANOV: This p
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11. EPIDEMIOLOGICAL AND VIROLOGICAL
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12. SPREAD OF A VACCINE STRAIN OF P
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148 Saf ety-Field Evidence of Saf e
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152 Saf ety-Field Evidence of Safet
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DISCUSSION CHAIRMAN ZHDANOV: The pa
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158 Discussion 158 Díscussion~~~~~
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160 Discussion specimens. We were u
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. . . 168 Safety-Field Evidence of
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14. THE CAPACITY OF LIVE ATTENUATED
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176 Saf ety-Field Evidence of Saf e
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... ____ v __ _"_ _. ___.__ __ .,_.
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Page 199 and 200: 182 Safety-Field Evidence of Safety
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Page 206 and 207: Field, Laboratory Experiences With
Page 208 and 209: 16. STUDIES ON LIVE POLIOVIRUS VACC
Page 210 and 211: Studies on Live Poliovirus Vaccine
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Page 220 and 221: Da. HORSTMANN: If I may answer for
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Page 224 and 225: NOTE: The Spanish translation of th
Page 226 and 227: Vaccination of Pregnant Women and Y
Page 246 and 247: Development and Persistence of Poli
Page 258 and 259: Virologic, Serologic Investigations
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Page 286 and 287: Discussion 269 in the investigation
Page 288 and 289: Virological Findings, Antibody Resp
Page 294 and 295: 4. ROUTINE IMMUNIZATION WITH ATTENU
Page 296 and 297: Routine Immunization With Attenuate
Page 298 and 299: Routine Immunization With Attenuate
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Routine Immunization With Attenuate
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Experimental Infectionwith CHATAtte
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Experimental Infection with CHATAtt
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Experimental Infection with CHATAtt
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Vaccination of Full-Term Infants wi
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Response of Newborn Infants to Vacc
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Susceptibility of Newborn Infants t
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9. IMMUNIZATION OF NEWBORN INFANTS
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Immunization of Newborn Infants wit
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Discussion 323 vaccinated siblings
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Discussion 325 Discussion 325 ance
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transplacental antibodies, or antib
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Discussion 329 Discussion 329 born
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Recent Experience with Lederle Triv
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11. FURTHER EXPERIENCES WITH ORAL P
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Further Experiences with Oral Polio
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Minnesota Studies with Oral Poliomy
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13. USE OF ATTENUATED LIVE POLIOVIR
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Use of Attenuated Live Poliovirus V
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Use of Attenuated Live Poliovirus V
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DISCUSSION CHAIRMAN LÉPINE: The tw
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Discussion 373 -~~~~~~ics o 7 domin
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Discussion 375 -~ ~~~~isuso 7 DR. C
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i 14. EFFECTS OF RAPID MASS IMMUNIZ
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Live Poliovirus Immunization-Condit
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Use of Sabin's Live Poliovirus Vacc
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- Use of Sabin's Live Poliovirus Va
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TABLE 14. Use of Sabin's Live Polio
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Discussion 411 DR. ANDERSON: My que
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Course of Mass Immunization in USSR
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, _ _ Course of Mass Immunization i
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DISCUSSION CHAIRMAN LÉPINE: Thank
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Discussion 431 DR. STUART-HARRIS: I
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436 Efficacy-Field Evidence TABLE 1
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438 Efficacy-Field Evidence Adminis
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444 Effcaey-Field Evidence 44 Efiay
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446 Efficacy-Field Evidence 446 Eff
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448 Efficacy-Field Evidence 448 lEf
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450 Efficacy-Field Evidence m Co 0
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452 Efficacy-Field Evidence ] ~~ ~
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454 Efficacy-Field Evidence It is n
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456 Efficacy-Field Evidence M.G. C
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460 460 Discussion Discussion~~~~~~
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462 Discussion one was sponsored by
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Vaccination with CHAT Strain Type 1
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Live Virus Vaccine Studies in South
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Discussion 481 the ages of the five
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Immunological and Epidemiological E
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DISCUSSION CHAIRMAN STUART-HARRIS:
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Further Observations on First Field
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Further Observations Qn First Field
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Further Observations on First FielJ
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Poliomyelitis Vaccination in Poland
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24. A SMALL-SCALE TRIAL WITH LIVE P
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Live Poliomyelitis Vaccine-Small-Sc
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25. VACCINATION AND CHALLENGE-POLIO
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Vaccination and Challenge-Poliomyel
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26. VACCINATION WITH ATTENUATED POL
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Vaccination with Attenuated Poliovi
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Discussion 575 ence last year. The
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Large-Scale Practical Trials, Use o
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594 Discussion 594 Disenísion ~ ~
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596 Discussion 596 Díscussion~~~~~
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598 Discussion 598 Discussion high
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iiiii iirrrimrmiriiiilllniririiiiii
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602 Summary of the Conference 602 S
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Appendix The following letter was r
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608 Index Antibodies-continued half
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610 Index Bulychev, N. P., paper, 4
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612 Index Coxsackie--continued B-3
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614 Index Epidemics-continued intro
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616 Index Genetic stability-continu
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618 Index Infants-continued source
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620 Index Laboratory surveillance d
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622 Index Monkey neurovirulence, 95
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624 Index pH neutralization test, 6
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626 Index Poliomyelitis virus-conti
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628 Index Serological response-cont
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630 Index T marker-continued T- str
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632 Index Vaccine, Attenuated-conti
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634 Index Virus isolations and anti
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LIVE POLIO IRUS VACCINES

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