LIVE POLIO IRUS VACCINES

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Virologic, Serologic Investigations of Immunization With Sabin's Strains 251 LOG.TCD 50 /G. 61 L.B., 31/2 months 36 DOays _ Type I m w m Type II mee Type III FIc. 3. R.L., 2 years Examples of simultaneous multiplication of vaccine strains on feeding live trivalent vaccine. TABLE 17. ESTABLISHMENT OF TYPE 3 VACCINE VIRUS IN PERSONS IMMUNIZED WITH TRIVALENT LIVE VACCINE, IN RELATION TO THE PRESENCE OR ABSENCE OF POLIOMYELITIS ANTIBODY ANTIBODY No. tested CHILDREN 30 96 10 2 ° 30 3+ 1+2+3+ number of children developing antibody after vaccination in the winter and in the summer was observed for Type 1 and Type 3 antibody (17.2 and 9.0 per cent, respectively). Table 21 and Figures 5, 6, and 7 present antibody titers in vaccinated children. It may be seen, that Type 1 antibody developed most often in titers 1:16-1:64; 25 per cent of the children
252 Efficacy-Laboratory Evidence TABLE 18. ANTIBODY RESPONSE IN SERONEGATIVE CHILDREN ONE MONTH AFTER ONE FEEDING WITH TRIVALENT LIVE VACCINE ANTIBODY DEVELOPMENT IN GROUPS OF "NEGATIVE" CHILDREN 10 2 ° 3 ° 10 20 3 ° TYPE 1 TYPE 2 TYPE 3 No. % No. % No. % No. % No. % No. % Moscow region 57* 73.1 82 89.1 60 69.8 19 61.3 24 77.1 18 58.1 (towns and 78 92 86 31 3 31 districts) L. children's 10 50.0 15 75.0 11 28.9 7 36.8 15 78.9 4 21.0 home 32 20 38 19 19 19 Karaganda 19 59.4 15 68.2 15 55.5 1 10.0 4 40.0 5 50.0 region 32 22 27 10 10 10 Moscow and 92 64.8 85 80.2 86 56.9 27 45.0 43 71.7 27 45.0 Karaganda 142 106 151 60 60 60 regions (summary data) Estonian SSR 28 71.8 20 83.3 8 73.3 8 61.5 10 76.9 10 76.9 (data by I. N. 39 24 30 13 13 13 Dobrova) ,57 í---57 of 78 children formerly Type 1 negative, developed Type I antibody. TABLE 19. ANTIBODY PATTERNS BEFORE VACCINATION AND ONE MONTH AFTER ONE FEEDING WITH TRIVALENT LIVE VACCINE FROM SABIN STRAINS IN 223 CHILDREN WITH ANTIBODY DEFICIENCY BEFORE VACCINATION ONE MONTH AFTER No. OF CHILDREN No. OF CHILDREN 000 60 26.9 9 4.0 00+ 12 5.4 5 2.2 0+0 37 16.6 25 11.2 0++ 33 14.8 14 6.3 +00 7 3.1 8 3.6 +0+ 27 12.1 5 2.2 ++0 47 21.1 29 13.0 _ 0 12 _5 0 0 128 57.3
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LIVE POLIO IRUS VACCINES Papers Pre
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SECOND INTERNATIONAL CONFERENCE ON
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Preface The accumulation of informa
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Page Discussion .......... .......
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Page 6. Vaccination of Full-Term In
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Page 23. Vaccination against Poliom
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Dr. Ghislain COURTOIS Director, Pri
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Dr. Edith PETTE Institute for the R
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4 Introductory Remarks 4 Introducto
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6 General Considerations immunity a
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8 General Considerations from accep
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10 General Considerations 10 Genera
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14 Safety-Laboratory Evidence of At
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- 26 Safety-Laboratory Evidence of
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DISCUSSION CHAIRMAN ANDERSON: There
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30 Discussion CHAIRMAN ANDERSON: Th
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32 TABLE 1. Safety-Laboratory Evide
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40 Discussion Of the 22 monkeys inf
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DISCUSSION CHAIRMAN ANDERSON: Thank
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46 Discussion a paralytic case. Thi
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48 Discussion + - + + I + - I + + 1
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50 Discussion sages of neurovirulen
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Application of Genetic Markers to D
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Discussion 67 TABLE 1. INCIDENCE OF
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Experimental Studies on Animals wit
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6. DETECTION OF A "NON-DETECTABLE"
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Detection of a "Non-Detectable" Sim
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Discussion 87 Dr. Koprowski's state
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Discussion 89 recognize its effects
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Laboratory Investigations of Attenu
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Discussion 99 In the case of Table
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8. BEHAVIOR OF COLD MUTANTS OF POLI
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Behavior of Cold Mutants of Poliovi
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DISCUSSION CHAIRMAN BURNET: Thank y
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114 Safety-Field Evidence of Safety
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118 S afety-Field Evidence of S af
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122 Discussion 122 Discussion~~~~~~
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10. LABORATORY INVESTIGATIONS OF TH
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126 VIRUS 1 MAhONEY Safety-Field Ev
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128 Safety-Field Evidence óf Safet
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DISCUSSION CHAIRMAN ZHDANOV: This p
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11. EPIDEMIOLOGICAL AND VIROLOGICAL
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12. SPREAD OF A VACCINE STRAIN OF P
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148 Saf ety-Field Evidence of Saf e
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152 Saf ety-Field Evidence of Safet
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DISCUSSION CHAIRMAN ZHDANOV: The pa
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158 Discussion 158 Díscussion~~~~~
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160 Discussion specimens. We were u
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. . . 168 Safety-Field Evidence of
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14. THE CAPACITY OF LIVE ATTENUATED
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176 Saf ety-Field Evidence of Saf e
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Field, Laboratory Experiences With
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16. STUDIES ON LIVE POLIOVIRUS VACC
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Studies on Live Poliovirus Vaccine
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Page 218 and 219: Studies on Live Poliovirus Vaccine
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Page 226 and 227: Vaccination of Pregnant Women and Y
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Page 258 and 259: Virologic, Serologic Investigations
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Vaccination of Full-Term Infants wi
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Response of Newborn Infants to Vacc
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Susceptibility of Newborn Infants t
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9. IMMUNIZATION OF NEWBORN INFANTS
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Immunization of Newborn Infants wit
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Discussion 323 vaccinated siblings
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Discussion 325 Discussion 325 ance
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transplacental antibodies, or antib
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Discussion 329 Discussion 329 born
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Recent Experience with Lederle Triv
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11. FURTHER EXPERIENCES WITH ORAL P
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Further Experiences with Oral Polio
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Minnesota Studies with Oral Poliomy
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13. USE OF ATTENUATED LIVE POLIOVIR
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Use of Attenuated Live Poliovirus V
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Use of Attenuated Live Poliovirus V
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DISCUSSION CHAIRMAN LÉPINE: The tw
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Discussion 373 -~~~~~~ics o 7 domin
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Discussion 375 -~ ~~~~isuso 7 DR. C
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i 14. EFFECTS OF RAPID MASS IMMUNIZ
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Live Poliovirus Immunization-Condit
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Use of Sabin's Live Poliovirus Vacc
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- Use of Sabin's Live Poliovirus Va
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TABLE 14. Use of Sabin's Live Polio
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Discussion 411 DR. ANDERSON: My que
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Course of Mass Immunization in USSR
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, _ _ Course of Mass Immunization i
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DISCUSSION CHAIRMAN LÉPINE: Thank
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Discussion 431 DR. STUART-HARRIS: I
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436 Efficacy-Field Evidence TABLE 1
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438 Efficacy-Field Evidence Adminis
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444 Effcaey-Field Evidence 44 Efiay
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446 Efficacy-Field Evidence 446 Eff
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448 Efficacy-Field Evidence 448 lEf
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450 Efficacy-Field Evidence m Co 0
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452 Efficacy-Field Evidence ] ~~ ~
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454 Efficacy-Field Evidence It is n
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456 Efficacy-Field Evidence M.G. C
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460 460 Discussion Discussion~~~~~~
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462 Discussion one was sponsored by
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Vaccination with CHAT Strain Type 1
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Live Virus Vaccine Studies in South
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Discussion 481 the ages of the five
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Immunological and Epidemiological E
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DISCUSSION CHAIRMAN STUART-HARRIS:
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Further Observations on First Field
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Further Observations Qn First Field
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Further Observations on First FielJ
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Poliomyelitis Vaccination in Poland
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24. A SMALL-SCALE TRIAL WITH LIVE P
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Live Poliomyelitis Vaccine-Small-Sc
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25. VACCINATION AND CHALLENGE-POLIO
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Vaccination and Challenge-Poliomyel
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26. VACCINATION WITH ATTENUATED POL
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Vaccination with Attenuated Poliovi
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Discussion 575 ence last year. The
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Large-Scale Practical Trials, Use o
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594 Discussion 594 Disenísion ~ ~
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596 Discussion 596 Díscussion~~~~~
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598 Discussion 598 Discussion high
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602 Summary of the Conference 602 S
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Appendix The following letter was r
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608 Index Antibodies-continued half
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610 Index Bulychev, N. P., paper, 4
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612 Index Coxsackie--continued B-3
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614 Index Epidemics-continued intro
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616 Index Genetic stability-continu
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618 Index Infants-continued source
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620 Index Laboratory surveillance d
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622 Index Monkey neurovirulence, 95
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624 Index pH neutralization test, 6
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626 Index Poliomyelitis virus-conti
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628 Index Serological response-cont
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630 Index T marker-continued T- str
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632 Index Vaccine, Attenuated-conti
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634 Index Virus isolations and anti
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LIVE POLIO IRUS VACCINES

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