Index 613 Dosage-continued statistics, USSR, 418 trivalent vaccine, optimum levels, 121 "Double blind study" need for, 157 no knowledge of vaccine or placebo, 461, 462 Douglas, GQrdon W., 321 DPT inoculation, 328, 597-598 Dragée-candy, 241, 264, 414 advantages, 419, 577, 585 Drobyshevskaya, A. I., paper, 482-501 Drozdov, S. G., paper 413-428; 416 Duben, J., paper 228-239 Dulbecco method plaque technique, 34 Dulbecco, Renato, 5, 7, 47, 49-50, 109-110, 268, 328- 329, 480, 505, 574 Dulutlh mass trial, 21,000 participants, 461 DuPan, R. Martin, 322, 323 Dyes photodynamic action, destruction of B virus, 87 Dysentery carrier vs. disseminator, 410 Dzagurov, S. G., paper, 413-428 E 206, see Poliomyelitis virus, Type 1, E 206 E marker, see Elution marker Earle's solution, 125, 229 East Germany, see German Democratic Republic Eastern equine encephalitis vaccine effectiveness when antiserum is added, 329 ECHO virases, 241, 246 isolation from suspected polio cases, 571 occurrence, 421, 537 ECHO 1 antiserum added to fecal suspensions before poliovirus isolation, 203 ECHO 1-14 identified, 271 ECHO 2, 14 in 7 unvaccinated infants, 273 ECHO 7, 8, 12, 14 isolated, Costa Rica, 575 ECHO 7, 14, 19 restricted to Franklin, Louisiana, 151 ECHO 8, 257 effect on spread of vaccine, 263 ECHO 10 similar to SA-III, 86 ECHO 12 interference, 181 ECHO 14, 19 restricted to Morgan City, Louisiana, 151 ECMO viruses, see Simian viruses Ecological behlavior, described, 110, 603 Economic conditions, see Socio-economic conditions Effectiveness analysis depends on triple negatives, 373, 444 and change in markers, 7 calculation on basis of all cases, 481 Cincinnati, Ohio, 591 controls selection, important in evaluating, 506 Effectiveness-continued criterion, 4, 371, 568, 579, 602 difference between number of expected and observed cases, 401 four Soviet republics, 497 high degree, 577 immunological and epidemiological, 482-501 Leopoldville, Congo, 466-473 long-range, determination, 445 Netherlands, 143 radical breakdowns in seasonal rise in polio, 493 related to interval between doses, 116 trivalent vaccine in young children, 113-120 Eiger, Marvin S., paper, 315-321 Eklund, C. M., 459, 462 Electrostal, USSR, 242 Elution marker differential adsorption on cellulose columns, 13 method detailed, 42, 43 Embil, Juan, paper 330-340, 365-370; 330 Embu district, Kenya, 479 EMC virus, possible contaminant, 474 Encephalitis in 9-year-old vaccinee, 593 incidence through trial period, 454 End point technique not sensitive enough, 237 Endanmoeba coli, Cuban children infested, 368 Endemic areas, Japan infants immunized with Salk, 191 Enders, J. F., 5 Endocrine factor susceptibility after birth enhanced, 300 England maternal antibody half-life study, 294 Type 3 specimens, 124 Enjoji, Dr.- (of Fukuoka University), 193 Enteroviruses and response to vaccination, 122, 179, 271, 274 clinical manifestations, 157 dissemination of, 411 86 episodes, 150 from sewage samples, a study, 439 identified in stools, 273, 368, 439 incidence compared with polioviruses, 380 interference, 8, 378, 394, 429, 575, 602 isolation, 400, 570, 591 Louisiana study, tabulated, 152, 153 prevalence among children, 182, 243 search in monkey kidney and human cell line, 123 Environment relation to results, 121 subtropical and polio, 184 Epidemics Aland archipelago, 1953, 536 and opponents of live virus vaccine, 8 Costa Rica, 1954, 561, 569, 575 Des Moines specific attack rates by dose and socio-economic class, 375 evolution, Nicaragua, 1959-60, 559 Hungary, 1959, 518 in lower economic groups, 158
614 Index Epidemics-continued introduced by steamer passengers, Rodrigues Island, 477 Kenya, 1954, 1957, 479 Nicaragua, 559, 574 occurrence, 414, 579 peak in 19th week, Managua, 548 provocation in severe epidemics, 597 reduced incidence with vaccine, 464, 586 season, Mauritius, 476 severe despite mass vaccination, 576 Tashkent, 1959, 586 type prediction based on immune state of community, 598 usual steps are palliative, 578 Type 1 Leopoldville, Congo, 466 Mauritius, 1959, 475, 477 Netherlands, 1956, 134 Tataki village, Japan, 1956, 191 Type 2 China, 1958, 595 Hanoi, North Viet Nam, 595 Nicaragua, 547, 595 Type 3 Ancienne Cité, Leopoldville, Congo, 472 Epidemiological effectiveness completeness of laboratory examination, 487 during endemic and epidemic period, 577 during field trial, 445-456 established in Soviet Union, 421 make judgement in future, 429 of polio by type, 174, 414 two control groups in each region, 486 Equatorial East Africa, monkey source, 79, 88 Equilibrium density gradient sedimentation purification of vaccine, 87 Equine infectious anemia tolerance study feasible, 328 Equine inhibitor marker to trace strains in population, 47 Eradication programs greatest difficulties at low disease level, 598 Erickson, George M., paper 435-444, 445-456; 124, 457, 459, 463 Eriksson, A. W., paper 533-546 Escherichia coli-dysentery means of control, 577 Estonian SSR, 240, 249 field trial, 580, 581 reduction of polio incidence, 421 two programs, 1960, 419, 582 Type 3 strains excreted, 39 Ether treatment destroys foamy agent, measles and B virus, 87 Evangeline, Louisiana lower economic neighborhood, 145 Evans, F. J., paper, 435-444 Excretion, see also Pharyngeal excretion, Fecal samples duration of vaccine, 313, 325, 601 vaccine strains fed at least 4 weeks, 275 Expert Committee on Poliomyelitis, see under World Health Organization Family, see also Intrafamily spread contacts asymptomatically infected, 7 feeding unit, 343 suspected cases investigated, 570 Fang-Cho, Ku, see Ku Fang-Cho Fecal samples collection and processing, 114, 145, 162, 163, 199, 223, 229, 240, 270, 294, 303, 309, 310, 315, 462, 487, 522, 527, 536, 554, 569 difficulty of obtaining, 143 entero- and polioviruses recovered and classified, 378 rectal swabs, efficiency, 592 virus content and age, 188 virus isolation rates, 28, 170 virus recovery and antibody development, 382 "Fecal-oral route" transmission of vaccine, 7 Feces supernatant suspension direct use in laboratory tests, 16, 132-133 Feeding schedules, 145, 401 and rates of infectability, 184 for Sottunga trial, 535 maximum immunogenic effect, 484 no correlation to dosage form and antibody response, 359 need for choice, 578, 585 optimum, USSR, 497 related to trivalent efficacy, 357-364 seven day, related to conversion rate, 366 virtues of repeated immunization, 505 Feeding sequence Multiple-feeding effectiveness, 363 no interference evident between strains, 296 superiority of, and increasing delinquency, 444 Types 1-3-2 monovaccines and optimum results, 420 Fendall, Dr. -, 479 Fenner, Dr. -, 110 Fergus, James W., paper, 207-227 Fetal loss and vaccination, 215 no attempt to isolate virus from fetus, 372 rate and antibody status, 269 rate by thirteenth week, 269 rate increase, in polio cases, 215 spontaneous, after vaccination, 214 Fetus affected by vaccination, 207, 602 vulnerable, and abortion rate, 269 Field trials by place Africa, southern, 474-479 Cincinnati, Ohio, 591 Costa Rica, 174-184, 561-573 Cuba, 365-370 Czechoslovakia, 507-521 Dade County, (Miami) Florida, 435-444; 445-456 Japan, 191-200 Kenya, 479 Kyriat Shmone, Israel, 270-276
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LIVE POLIO IRUS VACCINES Papers Pre
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SECOND INTERNATIONAL CONFERENCE ON
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Preface The accumulation of informa
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Page 6. Vaccination of Full-Term In
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Page 23. Vaccination against Poliom
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Dr. Ghislain COURTOIS Director, Pri
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Dr. Edith PETTE Institute for the R
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4 Introductory Remarks 4 Introducto
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6 General Considerations immunity a
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8 General Considerations from accep
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10 General Considerations 10 Genera
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14 Safety-Laboratory Evidence of At
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16 Safety-Laboratory Evidence of At
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18 Safety-Laboratory Evidence of At
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20 Safety-Laboratory Evidence of At
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22 Safety-Laboratory Evidence of At
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24 Safety-Laboratory Evidence of At
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DISCUSSION CHAIRMAN ANDERSON: There
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30 Discussion CHAIRMAN ANDERSON: Th
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32 TABLE 1. Safety-Laboratory Evide
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34 Safety-Laboratory Evidence of At
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36 Safety-Laboratory Evidence of At
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38 Safety-Laboratory Evidence of At
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40 Discussion Of the 22 monkeys inf
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42 Safety-Laboratory Evidence of At
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DISCUSSION CHAIRMAN ANDERSON: Thank
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46 Discussion a paralytic case. Thi
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48 Discussion + - + + I + - I + + 1
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50 Discussion sages of neurovirulen
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Application of Genetic Markers to D
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Application of Genetic Markers to D
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Application of Genetic Markers to D
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Application of Genetic Markers to D
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Application of Genetic Markers to D
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Application of Genetic Markers to D
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Discussion 67 TABLE 1. INCIDENCE OF
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Experimental Studies on Animals wit
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Experimental Studies on Animals wit
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Experimental Studies on Animals wit
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Experimental Studies on Animals wit
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Experimental Studies on Animals wit
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6. DETECTION OF A "NON-DETECTABLE"
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Detection of a "Non-Detectable" Sim
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Detection of a "Non-Detectable" Sim
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Detection of a "Non-Detectable" Sim
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Discussion 87 Dr. Koprowski's state
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Discussion 89 recognize its effects
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Laboratory Investigations of Attenu
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Laboratory Investigations of Attenu
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Laboratory Investigations of Attenu
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Laboratory Investigations of Attenu
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Discussion 99 In the case of Table
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8. BEHAVIOR OF COLD MUTANTS OF POLI
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Behavior of Cold Mutants of Poliovi
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Behavior of Cold Mutants of Poliovi
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Behavior of Cold Mutants of Poliovi
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DISCUSSION CHAIRMAN BURNET: Thank y
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114 Safety-Field Evidence of Safety
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116 Safety-Field Evidence of Safety
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118 S afety-Field Evidence of S af
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120 Safety-Field Evidence of Safety
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122 Discussion 122 Discussion~~~~~~
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10. LABORATORY INVESTIGATIONS OF TH
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126 VIRUS 1 MAhONEY Safety-Field Ev
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128 Safety-Field Evidence óf Safet
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130 Safety-Field Evidence of Safety
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DISCUSSION CHAIRMAN ZHDANOV: This p
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11. EPIDEMIOLOGICAL AND VIROLOGICAL
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136 Safety-Field Evidence of Safety
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138 Safety-Field Evidence of Safety
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140 Safety-Field Evidence of Safety
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142 Safety-Field Evidence of Safety
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12. SPREAD OF A VACCINE STRAIN OF P
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146 Safety-Field Evidence of Safety
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148 Saf ety-Field Evidence of Saf e
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150 Safety-Field Evidence of Safety
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152 Saf ety-Field Evidence of Safet
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154 Safety-Field Evidence of Safety
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DISCUSSION CHAIRMAN ZHDANOV: The pa
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158 Discussion 158 Díscussion~~~~~
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160 Discussion specimens. We were u
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162 Safety-Field Evidence of Safety
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164 Safety-Field Evidence of Safety
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166 Safety-Field Evidence of Safety
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. . . 168 Safety-Field Evidence of
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170 Safety-Field Evidence of Safety
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172 Safety-Field Evidence of Safety
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14. THE CAPACITY OF LIVE ATTENUATED
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176 Saf ety-Field Evidence of Saf e
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180 Safety-Field Evidence of Safety
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182 Safety-Field Evidence of Safety
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184 Safety-Field Evidence of Safety
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Field, Laboratory Experiences With
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16. STUDIES ON LIVE POLIOVIRUS VACC
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Studies on Live Poliovirus Vaccine
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Studies on Live Poliovirus Vaccine
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Studies on Live Poliovirus Vaccine
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Studies on Live Poliovirus Vaccine
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Da. HORSTMANN: If I may answer for
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Discussion 205 Discussion 205 tried
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NOTE: The Spanish translation of th
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Vaccination of Pregnant Women and Y
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Vaccination of Pregnant Women and Y
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Vaccination of Pregnant Women and Y
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Vaccination of Pregnant Women and Y
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Vaccination of Pregnant Women and Y
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Vaccination of Pregnant Women and Y
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Vaccination of Pregnant Women and Y
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Vaccination of Pregnant Women and Y
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Vaccination of Pregnant Women and Y
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Vaccination of Pregnant Women and Y
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Development and Persistence of Poli
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Development and Persistence of Poli
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Development and Persistence of Poli
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Development and Persistence of Poli
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Development and Persistence of Poli
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Development and Persistence of Poli
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Virologic, Serologic Investigations
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Virologic, Serologic Investigations
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Virologic, Serologic Investigations
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Virologic, Serologic Investigations
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Virologic, Serologic Investigations
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Virologic, Serologic Investigations
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Virologic, Serologic Investigations
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Virologic, Serologic Investigations
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Virologic, Serologic Investigations
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Virologic, Serologic Investigations
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Virologic, Serologic Investigations
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_ _ _ _ _ _ _ _ Virologic, Serologi
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Virologic, Serologic Investigations
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cARE NUC:4I Discussion 267 CUAw # J
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Discussion 269 in the investigation
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Virological Findings, Antibody Resp
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Virological Findings, Antibody Resp
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Virological Findings, Antibody Resp
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4. ROUTINE IMMUNIZATION WITH ATTENU
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Routine Immunization With Attenuate
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Routine Immunization With Attenuate
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Routine Immunization With Attenuate
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Experimental Infectionwith CHATAtte
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Experimental Infection with CHATAtt
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Experimental Infection with CHATAtt
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Vaccination of Full-Term Infants wi
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Vaccination of Full-Term Infants wi
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Vaccination of Full-Term Infants wi
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Vaccination of Full-Term Infants wi
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Response of Newborn Infants to Vacc
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Response of Newborn Infants to Vacc
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Response of Newborn Infants to Vacc
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Susceptibility of Newborn Infants t
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Susceptibility of Newborn Infants t
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Susceptibility of Newborn Infants t
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9. IMMUNIZATION OF NEWBORN INFANTS
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Immunization of Newborn Infants wit
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Immunization of Newborn Infants wit
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Immunization of Newborn Infants wit
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Discussion 323 vaccinated siblings
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Discussion 325 Discussion 325 ance
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transplacental antibodies, or antib
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Discussion 329 Discussion 329 born
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Recent Experience with Lederle Triv
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Recent Experience with Lederle Triv
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Recent Experience with Lederle Triv
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Recent Experience with Lederle Triv
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Recent Experience with Lederle Triv
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11. FURTHER EXPERIENCES WITH ORAL P
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Further Experiences with Oral Polio
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Further Experiences with Oral Polio
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Further Experiences with Oral Polio
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Further Experiences with Oral Polio
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Further Experiences with Oral Polio
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Further Experiences with Oral Polio
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Minnesota Studies with Oral Poliomy
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Minnesota Studies with Oral Poliomy
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Minnesota Studies with Oral Poliomy
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13. USE OF ATTENUATED LIVE POLIOVIR
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Use of Attenuated Live Poliovirus V
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Use of Attenuated Live Poliovirus V
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DISCUSSION CHAIRMAN LÉPINE: The tw
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Discussion 373 -~~~~~~ics o 7 domin
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Discussion 375 -~ ~~~~isuso 7 DR. C
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i 14. EFFECTS OF RAPID MASS IMMUNIZ
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Live Poliovirus Immunization-Condit
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Live Poliovirus Immunization-Condit
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Live Poliovirus Immunization-Condit
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Live Poliovirus Immunization-Condit
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Use of Sabin's Live Poliovirus Vacc
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Use of Sabin's Live Poliovirus Vacc
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Use of Sabin's Live Poliovirus Vacc
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- Use of Sabin's Live Poliovirus Va
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Use of Sabin's Live Poliovirus Vacc
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TABLE 14. Use of Sabin's Live Polio
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Use of Sabin's Live Poliovirus Vacc
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Use of Sabin's Live Poliovirus Vacc
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Use of Sabin's Live Poliovirus Vacc
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Use of Sabin's Live Poliovirus Vacc
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Use of Sabin's Live Poliovirus Vacc
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Use of Sabin's Live Poliovirus Vacc
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Discussion 411 DR. ANDERSON: My que
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Course of Mass Immunization in USSR
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Course of Mass Immunization in USSR
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Course of Mass Immunization in USSR
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Course of Mass Immunization in USSR
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, _ _ Course of Mass Immunization i
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Course of Mass Immunization in USSR
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Course of Mass Immunization in USSR
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DISCUSSION CHAIRMAN LÉPINE: Thank
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Discussion 431 DR. STUART-HARRIS: I
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436 Efficacy-Field Evidence TABLE 1
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438 Efficacy-Field Evidence Adminis
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440 Efficacy-Field Evidence TABLE 6
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442 Efficacy-Field Evidence TABLE 1
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444 Effcaey-Field Evidence 44 Efiay
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446 Efficacy-Field Evidence 446 Eff
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448 Efficacy-Field Evidence 448 lEf
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450 Efficacy-Field Evidence m Co 0
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452 Efficacy-Field Evidence ] ~~ ~
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454 Efficacy-Field Evidence It is n
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456 Efficacy-Field Evidence M.G. C
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458 Discussion 458 Discussion~~~~~~
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460 460 Discussion Discussion~~~~~~
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462 Discussion one was sponsored by
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464 Discussion 464 Discussion~~~~~~
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Vaccination with CHAT Strain Type 1
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Vaccination with CHAT Strain Type 1
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Vaccination with CHAT Strain Type 1
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Vaccination with CHAT Strain Type 1
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Live Virus Vaccine Studies in South
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Live Virus Vaccine Studies in South
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Live Virus Vaccine Studies in South
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Discussion 481 the ages of the five
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Immunological and Epidemiological E
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Immunological and Epidemiological E
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Immunological and Epidemiological E
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Immunological and Epidemiological E
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Immunological and Epidemiological E
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Immunological and Epidemiological E
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Immunological and Epidemiological E
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Immunological and Epidemiological E
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Immunological and Epidemiological E
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Immunological and Epidemiological E
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DISCUSSION CHAIRMAN STUART-HARRIS:
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Further Observations on First Field
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Further Observations Qn First Field
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Further Observations on First Field
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Further Observations on First FielJ
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Further Observations on First Field
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Further Observations on First Field
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Further Observations on First Field
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Poliomyelitis Vaccination in Poland
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Poliomyelitis Vaccination in Poland
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Poliomyelitis Vaccination in Poland
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Poliomyelitis Vaccination in Poland
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Poliomyelitis Vaccination in Poland
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24. A SMALL-SCALE TRIAL WITH LIVE P
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Live Poliomyelitis Vaccine-Small-Sc
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Live Poliomyelitis Vaccine-Small-Sc
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Live Poliomyelitis Vaccine-Small-Sc
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Live Poliomyelitis Vaccine-Small-Sc
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Live Poliomyelitis Vaccine-Small-Sc
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Live Poliomyelitis Vaccine-Small-Sc
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25. VACCINATION AND CHALLENGE-POLIO
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Vaccination and Challenge-Poliomyel
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Vaccination and Challenge-Poliomyel
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Vaccination and Challenge-Poliomyel
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Vaccination and Challenge-Poliomyel
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Vaccination and Challenge-Poliomyel
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Vaccination and Challenge-Poliomyel
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26. VACCINATION WITH ATTENUATED POL
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- Page 635 and 636: 618 Index Infants-continued source
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- Page 641 and 642: 624 Index pH neutralization test, 6
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