LIVE POLIO IRUS VACCINES

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Index 609 Attack rates-continued high in unvaccinated in US, 575 in Salk and non-Salk vaccinees, 480 in unvaccinated and vaccinated, 573 Mauritius, 476 Mexican cities, 386 Nicaragua, 1958, 1959, 547, 553, 575 Attenuated live poliovirus vaccine, see Vaccine, Attenuated Attenuation correlation with elution pattern, 44 neurovirulence for monkeys, most acceptable measure, 37 process described, 61 Sabin, Lederle-Cox strains compared, 12 Aureomycin to prevent enteritis, 68 Avidity differences in antibodies, 235 of antibodies during early stages of polio, 228 of nerve cells for attenuated vaccine, 49 of virus by the DEAE column, 42 role in immunity, 238 Axis cylinders paralysis and invasion of muscle neurons, 28 Azerbaijan SSR two programs, 1960, 419, 582 B virus destroyed by chloroform and ether, 87 destroyed by photodynamic action of dyes, 87 Babushkin, USSR, serum specimens, 242 Bacterial enterotoxins, destruction of polio, 300 Bacteriophage occurrence of covariation, 49 T7 burst size increased, conditions needed, 62 Balashikha, USSR, 242 Balkhash, USSR, examinations, 242 Baltic republics, see also specific country: Estonian SSR, Latvian SSR, Lithuanian SSR laboratory diagnosis substantiated, 420, 584 mass immunization, 1959, 576 Bard-Parker blade, ear-lobe puncture, 352 Barnes, J., paper 377-385; 101 Baron, Samuel, paper 90-97, 124-131; 86-88, 122-123, 132-133, 269 Barr, Robert N., paper 161-173, 341-354, 357-364; 226, 437, 459 Bauer, Henry, paper 161-173, 341-354, 357-364; 226, 371, 372 Bearman, Jacob E., paper 341-354, 357-364 Belgian Congo, see Congo Belgium protection rate of 98.2%, 532 Bell, Joseph A., 202, 506 Bellevue Hospital, N.Y.C., 315 Benyesh-Melnick, Matilda, paper, 12-26 Berman, Peter H., paper, 315-321 Beta-propiolactone inactivated vaccine conversion rate 98.6% in France, 532 Bias, in clinical interpretation, 344 Bicarbonate content effect on plaque formation, 188 Bicarbonate marker, see d marker Biologic systems describe relationships rather than absolute values, 480 descriptive grading system, advantages, 92 Biphasic process heterotypic antibodies had character of, 235 Birth-weight no relation to duration of virus excretion, 288 Black, F. L., 238 Blacksburg strain Newcastle disease vaccine, 327 Blind children dissemination and touch communication, 187-188 "Blind immunization" expectation very low, 505 Blood samples blood-soaked filter-paper, 351-352 collection and processing, 114, 145, 199, 208, 216, 229, 240, 270, 302, 331, 335, 359, 365, 439, 446, 464, 487, 523, 535, 554, 566, 569 for viremia studies, 351, 358, 362 whole laked blood, 364 Blood typing markers, compared, 458 Bodian, David, 49, 94, 98, 100, 109, 122, 133, 143, 157-158, 205-206, 329, 373-374, 457-459, 462, 505, 594, 596 Boiki, V. M., paper, 413-428 Booster age six months, 225 and initial feeding, 214 antibody rise and, 257 defined, 373 diseased children, 368 effect of increasing antibody concentration, 336 fourfold inereases or greater, 371 of second dose, 116 polyvalent vaccine, 483 presence of vaccine in community, 161 St. Joseph's Abbey, Worcester, Mass., study, 333 Salk status and, 302, 347 standards for measurement, 602 time for and immunologic response to, 207 Booth Memorial Hospital, St. Paul, Minnesota, 207 Borman, Gerald, paper 90-97, 124-131 Bottiger, Margareta, 188 Bovine amniotic fluid stool sample diluent, 536 Bovine serum marker strain tracer in population, 47 Boystown, Nebraska, Cuban equivalent, 366 Bozeman, S. R., 430 Brain, invasion, described, 39 Breast feeding no effect on vaccination, 324, 325 British Medical Journal, 205 Bronchopneumonia fatality in 9-month vaccinee, 197 Brunhilde see Poliomyelitis virus, Type 1, Brunhilde Brunner, K. T., 228 Buch, I., 530 Bulgaria vaccine supplied by USSR, 419, 582
610 Index Bulychev, N. P., paper, 482-501 Burian, V., 518 Burnet, Sir Macfarlane, 66-67, 86, 89, 93, 100, 109- 110, 328, 460-462 Buser, F., 322-323 Bustamante, Miguel E., paper, 386-409 Byelorussian SSR children up to 14 years immunized, 486, 488 field trial, 419, 581 paralytic polio in contacts, 485 paralytic polio in vaccinees, 493 Cabasso, Victor J., paper 31-37, 330-340; 30, 77, 122, 156, 208, 271, 330, 437, 540, 579 Cali, Colombia PASB Tissue Culture Laboratory, 569 Cancer continuous line cell culture and vaccine production, 599 Candau, M. G., 4 Candy, vaccine preservative, 415 Cape Town, Union of South Africa, 475 Carcinogenic viruses baby animals susceptible, 328 Cardelle, Gustavo, paper, 365-370 Carp, Richard, paper, 53-65; 64 Carrier 5%o of mothers in Toluca polio carriers, 410 Carrier state prevented, 6, 324 Cartago province, Costa Rica vaccination program, 1960, 563 Catholic home for children, Cleveland, 303 Catholic Infants' Home, St. Paul, Minnesota, 207 Cato, T. E., paper, 435-444 Cellulose resin avidity for virulent and attenuated polio, 41-43 Central nervous system (animal) antibody formation and occurrence of lesions, 77 direct inoculation measures different properties than IM, 125 invasion after IM inoculation in monkeys, 93 medium to encourage strain changes, 18 selection of virulent virus in monkey, 29 spreading, a strain variation, 98 Central nervous system (human) cases of non-paralytic, non-bacterial infections, 448- 451 epidemic, St. Petersburg, Florida, 458 inhibitory material, 86 investigation of diseases, 420, 535, 584, 601 isolation of virus, 77, 86 lesion-grading system, description, 91 no incidence following vaccinated, 368 none associated with vaccine, 390 vaccine invasive ability limited in children, 526 Central Province, Kenya 1,500,000 vaccinated, 479 Cervical area spread of Type 3 (Sabin), 13 Chacón Zamora, Jael, 118, 184 Chalkina, O. M., paper, 482-501 Chanock, R., 80 Chargaff dictum, 7 CHAT, see Vaccine, Attenuated, Type 1 CHAT (Koprowski) Cherry-flavored syrup, 114, 342, 387 Chesterfield, Lord, quotation, 7 Chi-square booster response calculation, 373 data on tables, 371 significance of protective effect of CHAT, 472 Chick-embryo tissue may contain chicken-cancer virus, 8 Chickenpox reactions after treatment with corticosteroid drugs, 461 Chicks immunized with live Newcastle vaccine, 327 Children age distribution establishment of vaccine, 243 immunity and vaccination status, 563 polio 1 month after vaccination, 481 pre-school, 277, 388, 506, 591 Toluca, Mexico, 379 vaccinees and controls, 487 antibody developed with no virus isolation, 383 antibody response, Sottunga, 544-545 behavior of cold-mutants in, 104, 107 congenital defects from measles, and vaccination. 329 contact data, 28, 187 frequency of vaccine excretion, 257, 313, 415, 421 high propagation coint in, 50 internal control group, described, 506 percentage of susceptible, 489 poor defense mechanisms, 461 prevaccination serologic survey, 246, 564 prolonged passage of Sabin strains, 46 results of increased neurovirulence, 50 Salk experience and lack of antibodies, 512 serological response greater than adults, 602 sick, virological examination of stools, 143 triple negatives, 273, 568 Children's homes Catholic, 207, 303 dose studies, Poland, 522, 527 dynamics of a study, USSR, 240-265 group description, Estonia, 431 Chimpanzees carrier state, established, 324 less sensitive to IS inoculation than monkeys, 18 neurovirulence test, 18 passive antibody level, 205, 329 reinfection rate studies, 158 China poliomyelitis epidemic, 1958, Type 2. 595 Soviet vaccine source, 419, 582 3% of monkeys have foamy agent, 88 Chinandega, Nicaragua epidemics, 1959-60, 547 Chloroform treatment destroys foamy agent, measles and B virus, 87 Cho, Ku Fang, see Ku Fang-Cho
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LIVE POLIO IRUS VACCINES Papers Pre
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SECOND INTERNATIONAL CONFERENCE ON
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Preface The accumulation of informa
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Page 6. Vaccination of Full-Term In
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Page 23. Vaccination against Poliom
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Dr. Ghislain COURTOIS Director, Pri
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Dr. Edith PETTE Institute for the R
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4 Introductory Remarks 4 Introducto
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6 General Considerations immunity a
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8 General Considerations from accep
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10 General Considerations 10 Genera
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14 Safety-Laboratory Evidence of At
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- 26 Safety-Laboratory Evidence of
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DISCUSSION CHAIRMAN ANDERSON: There
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30 Discussion CHAIRMAN ANDERSON: Th
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32 TABLE 1. Safety-Laboratory Evide
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40 Discussion Of the 22 monkeys inf
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DISCUSSION CHAIRMAN ANDERSON: Thank
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46 Discussion a paralytic case. Thi
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48 Discussion + - + + I + - I + + 1
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50 Discussion sages of neurovirulen
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Application of Genetic Markers to D
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Discussion 67 TABLE 1. INCIDENCE OF
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Experimental Studies on Animals wit
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6. DETECTION OF A "NON-DETECTABLE"
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Detection of a "Non-Detectable" Sim
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Discussion 87 Dr. Koprowski's state
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Discussion 89 recognize its effects
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Laboratory Investigations of Attenu
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Discussion 99 In the case of Table
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8. BEHAVIOR OF COLD MUTANTS OF POLI
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Behavior of Cold Mutants of Poliovi
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DISCUSSION CHAIRMAN BURNET: Thank y
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114 Safety-Field Evidence of Safety
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118 S afety-Field Evidence of S af
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122 Discussion 122 Discussion~~~~~~
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10. LABORATORY INVESTIGATIONS OF TH
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126 VIRUS 1 MAhONEY Safety-Field Ev
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128 Safety-Field Evidence óf Safet
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DISCUSSION CHAIRMAN ZHDANOV: This p
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11. EPIDEMIOLOGICAL AND VIROLOGICAL
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12. SPREAD OF A VACCINE STRAIN OF P
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148 Saf ety-Field Evidence of Saf e
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152 Saf ety-Field Evidence of Safet
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DISCUSSION CHAIRMAN ZHDANOV: The pa
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158 Discussion 158 Díscussion~~~~~
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160 Discussion specimens. We were u
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. . . 168 Safety-Field Evidence of
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14. THE CAPACITY OF LIVE ATTENUATED
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176 Saf ety-Field Evidence of Saf e
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Field, Laboratory Experiences With
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16. STUDIES ON LIVE POLIOVIRUS VACC
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Studies on Live Poliovirus Vaccine
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Da. HORSTMANN: If I may answer for
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Discussion 205 Discussion 205 tried
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NOTE: The Spanish translation of th
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Vaccination of Pregnant Women and Y
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Development and Persistence of Poli
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Virologic, Serologic Investigations
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_ _ _ _ _ _ _ _ Virologic, Serologi
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cARE NUC:4I Discussion 267 CUAw # J
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Discussion 269 in the investigation
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Virological Findings, Antibody Resp
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4. ROUTINE IMMUNIZATION WITH ATTENU
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Routine Immunization With Attenuate
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Experimental Infectionwith CHATAtte
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Experimental Infection with CHATAtt
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Experimental Infection with CHATAtt
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Vaccination of Full-Term Infants wi
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Response of Newborn Infants to Vacc
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Susceptibility of Newborn Infants t
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9. IMMUNIZATION OF NEWBORN INFANTS
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Immunization of Newborn Infants wit
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Discussion 323 vaccinated siblings
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Discussion 325 Discussion 325 ance
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transplacental antibodies, or antib
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Discussion 329 Discussion 329 born
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Recent Experience with Lederle Triv
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11. FURTHER EXPERIENCES WITH ORAL P
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Further Experiences with Oral Polio
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Minnesota Studies with Oral Poliomy
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13. USE OF ATTENUATED LIVE POLIOVIR
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Use of Attenuated Live Poliovirus V
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Use of Attenuated Live Poliovirus V
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DISCUSSION CHAIRMAN LÉPINE: The tw
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Discussion 373 -~~~~~~ics o 7 domin
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Discussion 375 -~ ~~~~isuso 7 DR. C
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i 14. EFFECTS OF RAPID MASS IMMUNIZ
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Live Poliovirus Immunization-Condit
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Use of Sabin's Live Poliovirus Vacc
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- Use of Sabin's Live Poliovirus Va
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TABLE 14. Use of Sabin's Live Polio
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Discussion 411 DR. ANDERSON: My que
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Course of Mass Immunization in USSR
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, _ _ Course of Mass Immunization i
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DISCUSSION CHAIRMAN LÉPINE: Thank
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Discussion 431 DR. STUART-HARRIS: I
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436 Efficacy-Field Evidence TABLE 1
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438 Efficacy-Field Evidence Adminis
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444 Effcaey-Field Evidence 44 Efiay
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446 Efficacy-Field Evidence 446 Eff
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448 Efficacy-Field Evidence 448 lEf
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450 Efficacy-Field Evidence m Co 0
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452 Efficacy-Field Evidence ] ~~ ~
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454 Efficacy-Field Evidence It is n
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456 Efficacy-Field Evidence M.G. C
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460 460 Discussion Discussion~~~~~~
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462 Discussion one was sponsored by
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Vaccination with CHAT Strain Type 1
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Live Virus Vaccine Studies in South
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Discussion 481 the ages of the five
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DISCUSSION CHAIRMAN STUART-HARRIS:
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Further Observations on First Field
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Further Observations Qn First Field
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Further Observations on First FielJ
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Poliomyelitis Vaccination in Poland
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24. A SMALL-SCALE TRIAL WITH LIVE P
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Live Poliomyelitis Vaccine-Small-Sc
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25. VACCINATION AND CHALLENGE-POLIO
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Vaccination and Challenge-Poliomyel
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Page 619 and 620: 602 Summary of the Conference 602 S
Page 622: Appendix The following letter was r
Page 625: 608 Index Antibodies-continued half
Page 629 and 630: 612 Index Coxsackie--continued B-3
Page 631 and 632: 614 Index Epidemics-continued intro
Page 633 and 634: 616 Index Genetic stability-continu
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Page 637 and 638: 620 Index Laboratory surveillance d
Page 639 and 640: 622 Index Monkey neurovirulence, 95
Page 641 and 642: 624 Index pH neutralization test, 6
Page 643 and 644: 626 Index Poliomyelitis virus-conti
Page 645 and 646: 628 Index Serological response-cont
Page 647 and 648: 630 Index T marker-continued T- str
Page 649 and 650: 632 Index Vaccine, Attenuated-conti
Page 651: 634 Index Virus isolations and anti
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LIVE POLIO IRUS VACCINES

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