LIVE POLIO IRUS VACCINES

530 Efficacy-Field Evidence
TABLE 10.t PRELIMINARY SEROLOGICAL RESULTS IN CHILDREN FED CHAT AND FOX STRAINS
IN LUBLIN*
Type of Blood Sera with no Antibodies Ratios of Sera with
Virus Samples Against Type Fed Before Antibodies Apninst 'vpe
Fed Obtained Immunization Fed After Immunization
Ratio
1 178 36 35/36 97
2 178 23 10/23 44
3 178 39 32/39 82
* Metabolic inhibition test in monkey-kidney tissue culture.
t Data collected by Drs. Mirkowski and I. Buch.
percentage of strains isolated might be explained
by the fact that the feces were collected
only 21-28 days after vaccination. Serologic
investigations are still under way.
The color test on MK-cells was used in our
study. Thus far, 176 sera have been examined.
They were collected before vaccination and 30
days after the administration of Type 3 virus,
i.e., 60 days after the administration of Type 1.
The results obtained are presented in Table 10.
The analysis of the immunogenic properties
of the vaccine was rendered difficult by the fact
that all the children had previously received at
least two vaccinations with the Salk vaccine.
In the 36 persons examined who had no antibodies
against Type 1 before vaccination, these
antibodies developed after the procedure.
Of 23 persons who had no antibodies against
Type 2, the antibodies developed after vaccination
in 10 cases. Of 39 persons who had no
antibodies against Type 3, 32 persons developed
these antibodies after vaccination. About 50
per cent of persons who had antibodies before
vaccination showed an approximately fourfold
increase to all three types of poliovirus. The
Institute of Naval Medicine at Gdafisk was also
engaged in similar investigations.
In order to ascertain the dissemination of
enteroviruses in the province of Gdafisk, feces
of 1,544 persons aged from one to seven years
were examined before the beginning of the vaccination
campaign. For results see Table 11.
TABLE 11.
EXCRETION OF VIRUS IN STOOLS OF CHILDREN FED THE CHAT AND Fox STRAINS
IN GDAoSKt
PER CENT POSITIVE STOOLS*
TYPE OF VIRUS ISOLATED
BEFORE VACCINATION
(No. = 1544)
AFTER TYPE 1
(No. = 682)
AFTER TYPE 3
(No. = 160)
11
29
10
2
3
2
1
3
2
2
43
Not polio
13
26
27
* Collected on the 5th and 9th days after administration of the respective viruses.
t Data collected by Drs. Georgiades and Morzycka.