LIVE POLIO IRUS VACCINES

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Application of Genetic Markers to Development and Control of Vaccine 55 TABLE 2. INTRATYPIC SERODIFFERENTIATION TEST WITH VIRUSES REPRESENTING PASSAGE OF CHAT STRAIN THROUGH HUMAN INTESTINAL TRACT VIRUS HUMAN % CONTROL PLAQUE DIAMETER UNDER ANTI-CHAT SERUM PASSAGE CHAT O B 117 1 . 10 Q-2 3 0 plaques without serum overlay. No differences were observed between the first and third human passage of the CHAT virus. The actual results of the intratypic serodifferentiation test applied to virus isolated in Leopoldville are shown on Table 3. Virus isolated from two healthy vaccinated infants showed serologic TABLE 3. MARKERS AS DETECTIVE AGENTS. INTRA- TYPIC SERODIFFERENTIATION TEST OF TYPE 1 POLIOVIRUSES ISOLATED FROM INHABITANTS OF LEOPOLDVILLE DURING VACCINATION CAMPAIGN WITH CHAT TYPE 1 VIRUS GROUP Vaccinated SUBJECTS CONDITION Healthy Sick % CONTROL PLAQUE* DIAMETER UNDER ANTI-CHAT SERUM OVERLAY O 10 32 36 38 Sick 32 36 40 Non- 43 Vaccinated 45 48 t 50 50 * Positive control results (CHAT virus)-0%. Negative control results (Mahoney virus)-0% identity with the CHAT virus. In contrast, virus isolated from three infants who became sick after vaccination and from eight non-vaccinated paralytic cases, seem to be unrelated serologically to the CHAT virus, since the reduction in plaque diameter under anti-CHAT serum overlay did not exceed, in general, that observed with the heterologous Mahoney virus. Another opportunity to investigate strains isolated during a vaccination campaign arose in Poland. Preliminary clinical and epidemiologic observations of this mass vaccination campaign, during which the entire country was immunized with the CHAT and Fox viruses, will be presented by Dr. Przesmycki. Strains isolated from six non-vaccinated children and three vaccinated children, all of whom who showed symptoms of disease, were submitted to our laboratory for identification, following preliminary typing in the Warsaw Laboratory. The results of the intratypic serodifferentiation test against anti- CHAT serum are shown in Table 4. They indicate clearly that all nine strains are as unrelated to the CHAT virus as was the Mahoney virus which was employed as the negative control in this test. A summary of intratypic serodifferentiation tests with Type 1 poliovirus isolated during vaccination programs in Moorestown, Leopoldville, and Poland is given in Table 5. All seven strains isolated from subjects who were either fed the CHAT virus or were in familial contact with those fed the virus in Moorestown showed serologic identity with the CHAT virus. Similarly, Type 1 virus isolated from two individuals in Leopoldville who exhibited no symptoms follow-
56 Safety-Laboratory Evidence of Attenuation and Safety TYPIC SERODIFFERENTIATION TEST OF TYPE 1 POLIOVIRUSES ISOLATED IN POLAND DURING THE VACCINATION CAMPAIGN GRouP Vaccinated TABLE 4. MARKERS AS DETECTIVE AGENTS. INTRA- Non- Vaccinated SUBJECTS CONDITION Sick Sick k % CONTROL PLAQUE* DIAMETER UNDER ANTI-CHAT SERUM 58 61 55 30 44 50 71 54 75 * Positive control results (CHAT virus)-
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LIVE POLIO IRUS VACCINES Papers Pre
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SECOND INTERNATIONAL CONFERENCE ON
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Preface The accumulation of informa
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Page 6. Vaccination of Full-Term In
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Page 23. Vaccination against Poliom
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Dr. Ghislain COURTOIS Director, Pri
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Dr. Edith PETTE Institute for the R
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Behavior of Cold Mutants of Poliovi
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Behavior of Cold Mutants of Poliovi
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DISCUSSION CHAIRMAN BURNET: Thank y
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114 Safety-Field Evidence of Safety
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118 S afety-Field Evidence of S af
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122 Discussion 122 Discussion~~~~~~
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10. LABORATORY INVESTIGATIONS OF TH
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126 VIRUS 1 MAhONEY Safety-Field Ev
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128 Safety-Field Evidence óf Safet
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DISCUSSION CHAIRMAN ZHDANOV: This p
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11. EPIDEMIOLOGICAL AND VIROLOGICAL
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12. SPREAD OF A VACCINE STRAIN OF P
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148 Saf ety-Field Evidence of Saf e
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152 Saf ety-Field Evidence of Safet
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DISCUSSION CHAIRMAN ZHDANOV: The pa
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158 Discussion 158 Díscussion~~~~~
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160 Discussion specimens. We were u
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. . . 168 Safety-Field Evidence of
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14. THE CAPACITY OF LIVE ATTENUATED
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176 Saf ety-Field Evidence of Saf e
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Field, Laboratory Experiences With
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16. STUDIES ON LIVE POLIOVIRUS VACC
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Studies on Live Poliovirus Vaccine
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Da. HORSTMANN: If I may answer for
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Discussion 205 Discussion 205 tried
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NOTE: The Spanish translation of th
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Vaccination of Pregnant Women and Y
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Development and Persistence of Poli
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Virologic, Serologic Investigations
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_ _ _ _ _ _ _ _ Virologic, Serologi
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cARE NUC:4I Discussion 267 CUAw # J
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Discussion 269 in the investigation
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Virological Findings, Antibody Resp
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4. ROUTINE IMMUNIZATION WITH ATTENU
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Routine Immunization With Attenuate
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Experimental Infectionwith CHATAtte
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Experimental Infection with CHATAtt
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Experimental Infection with CHATAtt
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Vaccination of Full-Term Infants wi
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Response of Newborn Infants to Vacc
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Susceptibility of Newborn Infants t
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9. IMMUNIZATION OF NEWBORN INFANTS
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Immunization of Newborn Infants wit
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Discussion 323 vaccinated siblings
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Discussion 325 Discussion 325 ance
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transplacental antibodies, or antib
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Discussion 329 Discussion 329 born
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Recent Experience with Lederle Triv
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11. FURTHER EXPERIENCES WITH ORAL P
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Further Experiences with Oral Polio
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Minnesota Studies with Oral Poliomy
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13. USE OF ATTENUATED LIVE POLIOVIR
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Use of Attenuated Live Poliovirus V
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Use of Attenuated Live Poliovirus V
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DISCUSSION CHAIRMAN LÉPINE: The tw
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Discussion 373 -~~~~~~ics o 7 domin
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Discussion 375 -~ ~~~~isuso 7 DR. C
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i 14. EFFECTS OF RAPID MASS IMMUNIZ
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Live Poliovirus Immunization-Condit
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Use of Sabin's Live Poliovirus Vacc
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- Use of Sabin's Live Poliovirus Va
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TABLE 14. Use of Sabin's Live Polio
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Discussion 411 DR. ANDERSON: My que
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Course of Mass Immunization in USSR
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, _ _ Course of Mass Immunization i
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DISCUSSION CHAIRMAN LÉPINE: Thank
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Discussion 431 DR. STUART-HARRIS: I
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436 Efficacy-Field Evidence TABLE 1
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438 Efficacy-Field Evidence Adminis
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444 Effcaey-Field Evidence 44 Efiay
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446 Efficacy-Field Evidence 446 Eff
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448 Efficacy-Field Evidence 448 lEf
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450 Efficacy-Field Evidence m Co 0
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452 Efficacy-Field Evidence ] ~~ ~
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454 Efficacy-Field Evidence It is n
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456 Efficacy-Field Evidence M.G. C
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460 460 Discussion Discussion~~~~~~
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462 Discussion one was sponsored by
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Vaccination with CHAT Strain Type 1
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Live Virus Vaccine Studies in South
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Discussion 481 the ages of the five
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Immunological and Epidemiological E
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DISCUSSION CHAIRMAN STUART-HARRIS:
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Further Observations on First Field
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Further Observations Qn First Field
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Further Observations on First FielJ
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Poliomyelitis Vaccination in Poland
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24. A SMALL-SCALE TRIAL WITH LIVE P
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Live Poliomyelitis Vaccine-Small-Sc
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25. VACCINATION AND CHALLENGE-POLIO
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Vaccination and Challenge-Poliomyel
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26. VACCINATION WITH ATTENUATED POL
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Vaccination with Attenuated Poliovi
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Discussion 575 ence last year. The
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Large-Scale Practical Trials, Use o
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594 Discussion 594 Disenísion ~ ~
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596 Discussion 596 Díscussion~~~~~
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598 Discussion 598 Discussion high
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602 Summary of the Conference 602 S
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Appendix The following letter was r
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608 Index Antibodies-continued half
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610 Index Bulychev, N. P., paper, 4
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612 Index Coxsackie--continued B-3
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614 Index Epidemics-continued intro
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616 Index Genetic stability-continu
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618 Index Infants-continued source
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620 Index Laboratory surveillance d
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622 Index Monkey neurovirulence, 95
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624 Index pH neutralization test, 6
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626 Index Poliomyelitis virus-conti
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628 Index Serological response-cont
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630 Index T marker-continued T- str
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632 Index Vaccine, Attenuated-conti
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634 Index Virus isolations and anti
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