LIVE POLIO IRUS VACCINES

566
Efficacy-Field Evidence
established in the prevaccination survey to the
total number of children vaccinated with monovalent
and trivalent vaccines. Distribution of
these seronegatives as single, double, and triple
negatives, and of the triple positives is shown by
age in Table 5.
Results of serologic assays of the responses of
children of various ages to the monovalent and
trivalent vaccines and of infants to vaccination
in the first week of life are summarized in Table
6 below and Fig. 3. The post-vaccination blood
samples from vaccinated newborns were collected
from five to eight months after vaccination and
the frequencies of seronegatives among them
were compared with those found among unvaccinated
infants under one year of age in the pre.
vaccination survey. Table 7 summarizes the responses
to monovalent vaccine by age for each
type and the percentages for all three.
DISCUSSION
An ample system for the reporting of untoward
reactions following vaccine ingestion was
established at the start of the vaccination campaign.
Reports were received of many instances
of gastro-intestinal disturbances, skin reactions,
respiratory distress, and miscellaneous complaints
which were duly investigated and treated
when necessary. There was no evidence of
etiological relationship of any of these complaints
to the vaccine. The number of such
reports steadily declined as the program progressed
and its novelty wore off.
TABLE 5.
PREVACCINATION ANTIBODY STATUS OF 664 INDIVIDUALS BY AGE
No
ANTIBODIES
TO