LIVE POLIO IRUS VACCINES

Course of Mass Immunization in USSR with Vaccine from Sabin's Strains
415
1959) proving satisfactory preservation of vaccine
strains in strong solutions of inverted sugars
and in the sweetmeat mass at sub-zero temperatures
for at least three months, at 4 ° C. for about
a month and at room temperature for three to
five days.
Tests for the virus content in dragée-candy by
the plaque method (data by S. G. Dzagurov and
co-workers, V. A. Lashkevich and co-workers,
and also by Dr. A. B. Sabin, 1960) confirmed
the good preservation of the vaccine in candy and
even distribution of the virus in individual pieces
TABLE 1. FREQUENCY OF VACCINE VIRUS EXCRETION IN CHILDREN IMMUNIZED
ATTENUATED VACCINE IN POMADKA-CANDY
(Town of Klin, 1959. G. P. Fleer)
WITH
TRIVALENT
UNDER SURVEY
VIRUS ISOLATION
AVERAGE
AGE-
GROUP
NUMBER OF
CHILDREN
NUMBER OF
STOOLS
FROM
EACH CHILD
TOTAL No.
OF STOOLS
PER AGE-
GROUP
NUMBER OF
CHILDREN
TO THE
NUMBER
TESTED
FROM STOOL
SPECIMENS
No. %
4 mos.-3 yrs. 30 4 118 28 93 78 66
3-7 yrs. 12 3 38 10 85 25 66
7-15 yrs. 48 3 158 43 89 97 61
Total 90 314 81 90 200 63.7
TABLE 1A. ESTABLISHMENT OF TYPE 1 VACCINE IN DRAGCE-CANDY IN CHILDREN FROM CHILDREN 'S
HOME No. 15
No. OF CHILDREN
NUMBER OF CHILDREN EXCRETIN G VIRUS AFTER VACCINATION
TESTED (WITHOUT
PREVACCINATION 3 7 10 14 17 21
VIRUS CARRIAGE) _ -
AT INDICATEED DAYS
25 28 Total number of children
excreting virus
27 11 12 19 14 16 9
3 2 27
100.0%
TABLE 2. EXCRETION OF TYPE 1 VACCINE POLIOVIRUS IN CHILDREN IMMUNIZED WITH LIVE TYPE 1
MONOVACCINE IN DRAGÉE-CANDY
(Moscow Children's homes, 1960. E. E. Ashmarina)
NUMBER OF CHILDREN
WITHOUT VIRUS CARRIAGE
BEFORE VACCINATION
NUMBER OF STOOL SPECIMENS
TESTED (FOR 4 WEEKS)
% OF FINDING OF VACCINE
VIRUS TO THE NUMBER
OF CHILDREN
Children's home No. 11
37
Children's home No. 15
45
Total 82
331
402
T o1tal 8 2 7 3 3
94
93
93.9