LIVE POLIO IRUS VACCINES

382
Efficacy-Laboratory Evidence
TABLE 4. POLIO ANTIBODY CONVERSION RATES IN TOLUCA, MEXICO AMONG "SINGLE-NEGATIVE",
"DOUBLE-NEGATIVE" AND "TRIPLE-NEGATIVE" CHILDREN 10 WEEKS AFTER FEEDING SINGLE DOSE OF
TRIVALENT VACCINE (0.01 ML. OF EACH-105.2 TO 105 6 1 TCD 5 ,)
TYPE
1
2
3
SINGLE-NEGATIVE D¥O1TBLE-NEGATIVE TRIPLE-NEGATIVE TOTAL
_ _ --, 1 - 1-- _ _ _
No.
TESTED
4
17
17
CON-
VERTED
100
82
59
No.
TESTED
16
25
24
o
CON-
VERTED
''----'----'---
88
80
42
No.
TESTED
33
35
35
CON-
VERTED
55
83
37
No.
TESTED
53
77
76
CON-
VERTED
68
82
43
TABLE 5. INCIDENCE OF VIRUS RECOVERY FROM RECTAL SWABS IN RELATION TO DEVELOPMENT OF
ANTIBODY. ESTIMATE OF TOTAL INFECTION RATE DURING 10-WEEK PERIOD FOLLOWING SINGLE ORAL
DOSE OF TRIVALENT VACCINE IN TOLUCA, MEXICO
CATEGORY
TYPE 1 TYPE 2
No. % No.
TYPE 3
No. %
VIRUS IN RECTAL SWABS AMONG THOSE WHO:
a) DEVELOPED ANTIBODY 12/36 33 52/63 82 21/33 64
b) FAILED TO DEVELOP ANTIBODY 2/17 12 3/14 21 2/43 5
ESTIMATE OF TOTAL INFECTION RATE 42/53 80 67/77 87 36/76 47
DEVELOPMENT OF ANTIBODY AMONG TOTAL
NO. INFECTED (DEMONSTRATED+ESTIMATED) 36/42 86 63/67 94 33/36 92
TABLE 6. CONVERSION RATES AT DIFFERENT TIMES AFTER FEEDING Two DOSES OF TRIVALENT
POLIOVIRUS VACCINE (105.2 TO 105
' 6 TCD 5 0 ) IN TOLUCA, MEXICO
TYPE
PER CENT CONVERTED AT INDICATED TIME AFTER
NO. OF
TYPE NHOROF FIRST DOSE - MASS FEEDING SECOND DOSE-neg.only BOTH DOSES
CHILDREN
TrESTED First I0 weeks Subsequent Ilweeks 6 weeks
OAUG'59 to+ OCT'5900C59 to +JAN60JAN.'60 to + FEB
FEB'6OAUG59 toFEB'
1 53 68 7 85 96
2 77 82 0 73 96
3 76 43 3 48 72