LIVE POLIO IRUS VACCINES

Discussion
67
TABLE 1. INCIDENCE OF STRAINS WITH CAPACITY TO PROPAGATE AT 400 C (T/40+) AMONG
NATURALLY OCCURRING POLIOVIRUSES OF DIVERSE ORIGIN AND AMONG VIRUSES EXCRETED BY
PERSONS AFTER INGESTION OF ATTENUATED POLIOVIRUS VACCINES
SOURCE OF STRAINS
TYPE
1
NO.
TYPE
Z
TESTED
TYPE
3
NO. t/40
r -
4 0
TOTAL TYPE
-+
+
CLINICAL POLIOMYELITIS
STOOLS - EARLY AFTER ONSET 29 3 4 36 All 36 0 0
CNS - FATAL CASES 15 - 1 16 All 13 3 0
STOOLS OF HEALTHY CHILDREN 20 17 21 58 1 17 2 1
DURING NON-EPIDEMIC PERIODS 2 13 4 0
NO KNOWN C ONTACT WITH CASES 3 12 7 2
STOOLS OF VACCINATED 44 38 42 124 1 0 0 44
2 1 1 I,
3 15 20 7
STOOLS OF VACCINE CONTACTS 5 _ 27 32 1 0 0
3 26 I 0
tissue would not multiply at 400 C. and yet was
neurovirulent for the monkey. On the other
hand, there were rct/40+ strains of very low
virulence for the monkey.
DR. VOROSHILOVA: We have studied the temperature
marker of the strains which were
isolated from the patients in Karaganda (40 of
Type 1, 12 of Type 2, and 5 of Type 3.) Thirtyfour
strains of Type 1 were isolated from children
that had not been vaccinated. Thirty-one
of them possessed a T+ marker and three, a
T~ marker. There was none of the T- strains.
Of 12 strains of Type 2, all had marker T+.
Of five strains of Type 3, one was T+ and four
were T--. In one of those cases the child had
no contact with vaccinees because this took place
before the vaccination campaign. Perhaps in
three cases alone there might have been some
contagion from children who had been vaccinated.
Of the six strains of the Type 1 isolated from
vaccinated children, three had T+, one T-, and
two had a T- marker.
On the two strains of the Type 2 isolated from
vaccinated children, both belonged to the T-
type.
On the four strains of the Type 3, one had
T+, two T-, and one a T- marker.
In this way, of all the strains isolated from
non-vaccinated children, only one had definitely
the T- marker. Most of the others had T+
and three strains of the Type 1 T- marker.
Thus, it is obvious that this is the exception
which has been mentioned by Dr. Sabin.
CHAIRMAN BURNET: The next paper will be
presented by Dr. Pette on "Experimental Studies
on Animals with Attenuated Poliovirus (Cox and
Sabin Strains). This is to be followed by Dr.
Sweet's and Dr. Hilleman's paper on "Detection
of a 'Non-Detectable' Simian Virus (Vacuolating
Agent) Present in Rhesus and Cynomolgus
Monkey-Kidney Cell Culture Material." The
discussion on these papers will take place after
these presentations.