LIVE POLIO IRUS VACCINES

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Capacity of Live Attenuated Polioviruses to Cause Human Infection 175 VA(CC NATIOH V~CCINATION DATA JULY AUGUST SEPTEMBER OCT FIc. 1 rm r -I --- · I- I I I_ = -_· = - _ DaTA 1 UU A
176 Saf ety-Field Evidence of Saf ety 176 Safety-Field Evidence of Safety cess of vaccination to one type of poliovirus. Shaded areas on the right-hand side of the chart represent a significant rise in antibodies for let us say, Type 1 poliovirus. Here, in mid-August it has been assumed that 40 of the 48 potential vaccinees developed Type 1 antibodies after receiving the first dose of triple vaccine and the remaining 8 candidates responded to the second dose in early September giving a 100 per cent favorable response by early October. Next the infectability of the strains used in the trial depicted only in terms of antibody responses in each of the 48 index (vaccinated) children is given in Figures 3, 4, and 5 to illustrate the results with Types 1, 2, and 3, respectively. In Figure 3 is shown the actual response in the development of Type 1 antibodies in the Costa Rican village population. The shaded area running across the right lower part of the chart indicates that 31 of the 48 vaccinees developed antibodies in two waves after the two doses of triple vaccine. None possessed antibodies prior to receiving the first dose of vaccine. Before the study was over six vaccinees had been lost and so their final antibody status (as of early October) remains undetermined. Figure 4 illustrates results with Type 2 antibodies in the Costa Rican village population. The shaded area running across the entire lower third of the chart indicates that 13 of the potential vaccinees possessed antibodies to Type 2 prior to the first dose of vaccine. Ten others converted from negative to positive during the period of observation. Figure 5 illustrates the antibody response to Type 3 in terms of the diagram in the previous charts. Superimposed on this type of diagram there is shown, in Figure 6, not only the antibody responses but the days on which Type 1 poliovirus was isolated and the days on which non-poliovirus enteroviruses were isolated, and the complex relationship between the two. Figure 6 illustrates the antibody response to Type 1 attenuated poliovirus as already shown in Fig. 3, and on it has been superimposed a system for demonstrating the actual days in which Type 1 poliovirus was isolated either for brief or FIG. 3
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LIVE POLIO IRUS VACCINES Papers Pre
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SECOND INTERNATIONAL CONFERENCE ON
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Preface The accumulation of informa
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Page Discussion .......... .......
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Page 6. Vaccination of Full-Term In
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Page 23. Vaccination against Poliom
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Dr. Ghislain COURTOIS Director, Pri
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Dr. Edith PETTE Institute for the R
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4 Introductory Remarks 4 Introducto
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6 General Considerations immunity a
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8 General Considerations from accep
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10 General Considerations 10 Genera
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14 Safety-Laboratory Evidence of At
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- 26 Safety-Laboratory Evidence of
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DISCUSSION CHAIRMAN ANDERSON: There
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30 Discussion CHAIRMAN ANDERSON: Th
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32 TABLE 1. Safety-Laboratory Evide
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40 Discussion Of the 22 monkeys inf
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DISCUSSION CHAIRMAN ANDERSON: Thank
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46 Discussion a paralytic case. Thi
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48 Discussion + - + + I + - I + + 1
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50 Discussion sages of neurovirulen
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Application of Genetic Markers to D
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Discussion 67 TABLE 1. INCIDENCE OF
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Experimental Studies on Animals wit
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6. DETECTION OF A "NON-DETECTABLE"
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Detection of a "Non-Detectable" Sim
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Discussion 87 Dr. Koprowski's state
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Discussion 89 recognize its effects
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Laboratory Investigations of Attenu
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Discussion 99 In the case of Table
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8. BEHAVIOR OF COLD MUTANTS OF POLI
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Behavior of Cold Mutants of Poliovi
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DISCUSSION CHAIRMAN BURNET: Thank y
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114 Safety-Field Evidence of Safety
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118 S afety-Field Evidence of S af
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122 Discussion 122 Discussion~~~~~~
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Page 149 and 150: DISCUSSION CHAIRMAN ZHDANOV: This p
Page 151 and 152: 11. EPIDEMIOLOGICAL AND VIROLOGICAL
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Page 165 and 166: 148 Saf ety-Field Evidence of Saf e
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Page 173 and 174: DISCUSSION CHAIRMAN ZHDANOV: The pa
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Page 177 and 178: 160 Discussion specimens. We were u
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Page 206 and 207: Field, Laboratory Experiences With
Page 208 and 209: 16. STUDIES ON LIVE POLIOVIRUS VACC
Page 210 and 211: Studies on Live Poliovirus Vaccine
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Page 220 and 221: Da. HORSTMANN: If I may answer for
Page 222 and 223: Discussion 205 Discussion 205 tried
Page 224 and 225: NOTE: The Spanish translation of th
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Vaccination of Pregnant Women and Y
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Vaccination of Pregnant Women and Y
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Development and Persistence of Poli
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Virologic, Serologic Investigations
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_ _ _ _ _ _ _ _ Virologic, Serologi
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cARE NUC:4I Discussion 267 CUAw # J
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Discussion 269 in the investigation
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Virological Findings, Antibody Resp
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4. ROUTINE IMMUNIZATION WITH ATTENU
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Routine Immunization With Attenuate
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Experimental Infectionwith CHATAtte
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Experimental Infection with CHATAtt
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Experimental Infection with CHATAtt
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Vaccination of Full-Term Infants wi
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Response of Newborn Infants to Vacc
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Susceptibility of Newborn Infants t
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9. IMMUNIZATION OF NEWBORN INFANTS
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Immunization of Newborn Infants wit
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Discussion 323 vaccinated siblings
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Discussion 325 Discussion 325 ance
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transplacental antibodies, or antib
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Discussion 329 Discussion 329 born
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Recent Experience with Lederle Triv
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11. FURTHER EXPERIENCES WITH ORAL P
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Further Experiences with Oral Polio
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Minnesota Studies with Oral Poliomy
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13. USE OF ATTENUATED LIVE POLIOVIR
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Use of Attenuated Live Poliovirus V
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Use of Attenuated Live Poliovirus V
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DISCUSSION CHAIRMAN LÉPINE: The tw
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Discussion 373 -~~~~~~ics o 7 domin
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Discussion 375 -~ ~~~~isuso 7 DR. C
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i 14. EFFECTS OF RAPID MASS IMMUNIZ
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Live Poliovirus Immunization-Condit
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Use of Sabin's Live Poliovirus Vacc
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- Use of Sabin's Live Poliovirus Va
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TABLE 14. Use of Sabin's Live Polio
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Discussion 411 DR. ANDERSON: My que
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Course of Mass Immunization in USSR
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, _ _ Course of Mass Immunization i
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DISCUSSION CHAIRMAN LÉPINE: Thank
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Discussion 431 DR. STUART-HARRIS: I
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436 Efficacy-Field Evidence TABLE 1
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438 Efficacy-Field Evidence Adminis
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444 Effcaey-Field Evidence 44 Efiay
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446 Efficacy-Field Evidence 446 Eff
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448 Efficacy-Field Evidence 448 lEf
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450 Efficacy-Field Evidence m Co 0
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452 Efficacy-Field Evidence ] ~~ ~
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454 Efficacy-Field Evidence It is n
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456 Efficacy-Field Evidence M.G. C
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460 460 Discussion Discussion~~~~~~
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462 Discussion one was sponsored by
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Vaccination with CHAT Strain Type 1
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Live Virus Vaccine Studies in South
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Discussion 481 the ages of the five
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Immunological and Epidemiological E
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DISCUSSION CHAIRMAN STUART-HARRIS:
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Further Observations on First Field
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Further Observations Qn First Field
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Further Observations on First FielJ
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24. A SMALL-SCALE TRIAL WITH LIVE P
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Live Poliomyelitis Vaccine-Small-Sc
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25. VACCINATION AND CHALLENGE-POLIO
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Vaccination and Challenge-Poliomyel
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26. VACCINATION WITH ATTENUATED POL
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Vaccination with Attenuated Poliovi
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Discussion 575 ence last year. The
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Large-Scale Practical Trials, Use o
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594 Discussion 594 Disenísion ~ ~
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596 Discussion 596 Díscussion~~~~~
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598 Discussion 598 Discussion high
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602 Summary of the Conference 602 S
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Appendix The following letter was r
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608 Index Antibodies-continued half
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610 Index Bulychev, N. P., paper, 4
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612 Index Coxsackie--continued B-3
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614 Index Epidemics-continued intro
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616 Index Genetic stability-continu
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618 Index Infants-continued source
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620 Index Laboratory surveillance d
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622 Index Monkey neurovirulence, 95
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624 Index pH neutralization test, 6
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626 Index Poliomyelitis virus-conti
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628 Index Serological response-cont
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630 Index T marker-continued T- str
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632 Index Vaccine, Attenuated-conti
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634 Index Virus isolations and anti
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