LIVE POLIO IRUS VACCINES

Virologic, Serologic Investigations of Immunization With Sabin's Strains 261
.c mean
_
'
Type I
Type I
~- Type III 1
L§ &S
!
.... 11j6.'
¡ u
;.0u/ a0,
4,/
1e
FIG. 9.
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o
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VIII IX I X l lII 1 11 IIl t months
t t 1 1
1I.1.11l I.II l.111
Dynamics of antibody titers in seronegative children after two feedings with live liquid vaccine
Types 1, 2, 3; candy Type 1; candy Types 1, 2, 3 (children's home in Lyubertsy).
TABLE 26. ISOLATION OF ATTENUATED VIRUS OF POLIOMYELITIS TYPE 2 FROM CHILDREN (0-3 YRS.)
WITH CYTOPATHOGENIC AGENTS "CPA+-" AND WITHOUT CYTOPATHOGENIC AGENTS "CPA-" DURING
THE 14 DAYS AFTER IMMUNIZATION
1 +2 WEEKS
3+4 WEEKS
CHILDREN
CPA-
CPA+
CPA-
CPA+
Investigated 107 70 107 70
Virus isolated 71 21 59 29
Per cent 66 30 55 24
live trivalent vaccine, despite the fact that by
this time some children are still virus carriers
after the first feeding. In contrast to this, Type
3 vaccine virus was excreted by a larger number
of children in children's homes L. and R. after
the second feeding than after the first feeding.
One may suppose that, after the first feeding,
extensive multiplication of this virus was prevented
by the high extent of infection with nonpoliomyelitis
enteric viruses. Three months after