LIVE POLIO IRUS VACCINES

Further Observations on First Field Trial in Czechoslovakia
513
30
20 _
A
BOHEMIA AND MORAVIA
( without reg/ons where Sabin's live vaccine was used)
10
O /
50 -
4.
"_
I i !
40o-
SL O VA KIA
30 -
20--
non- vacc.
- - - - vaccínated
1o0 -
o
o
5 10
15 age
FiG. 4.
Poliomyelitis morbidity in children in 1959, by age.
methods. While after the live vaccine, predominantly
higher titers were obtained, particularly
of Type 1 antibodies, the antibody responses
after the fourth dose of inactivated vaccine are
quantitatively weaker (Table 4). Frequently,
particularly in children also lacking antibodies
against Type 2, no booster effect was recorded.
The weak antibody response resembled rather
the primary immunization reaction* (Table 5).
* For the basic intradermal vaccination with inactivated
vaccine the Canadian vaccine (Connaught
Laboratories) was used. For the fourth dose administered
in Plzefi region one lot of locally produced
vaccine was used (Institute for Sera and Vaccines,
Prague).