LIVE POLIO IRUS VACCINES

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_____~~~~~~~~~~~~~~~~~~~~~~ FIFTH SESSION WEDNESDAY, 8 JUNE 1960, 9:00 A.M. Chairman DR. HERMAN E. HILLEBOE Commissioner of Health New York State Department of Health Albany, New York TOPIC III. EFFICACY. (A) LABORATORY EVIDENCE (continuation) (1) ANTIBODY RESPONSE (b) Influence of Age Presentation of Papers by: Dr. Joseph S. Pagano Dr. Stanley A. Plotkin Dr. Frederick C. Robbins Dr. Henry M. Gelfand Dr. Saul Krugman (DISCUSSION) (c) Influence of Dosage and Regimen Presentation of Papers by: Dr. Herald R. Cox Dr. Herman Kleinman 285
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LIVE POLIO IRUS VACCINES Papers Pre
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SECOND INTERNATIONAL CONFERENCE ON
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Preface The accumulation of informa
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Page Discussion .......... .......
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Page 6. Vaccination of Full-Term In
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Page 23. Vaccination against Poliom
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Dr. Ghislain COURTOIS Director, Pri
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Dr. Edith PETTE Institute for the R
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imimmmmmñimmimmm-ñmñmñrmimmimmm
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4 Introductory Remarks 4 Introducto
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6 General Considerations immunity a
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8 General Considerations from accep
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10 General Considerations 10 Genera
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14 Safety-Laboratory Evidence of At
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- 26 Safety-Laboratory Evidence of
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DISCUSSION CHAIRMAN ANDERSON: There
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30 Discussion CHAIRMAN ANDERSON: Th
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32 TABLE 1. Safety-Laboratory Evide
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40 Discussion Of the 22 monkeys inf
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DISCUSSION CHAIRMAN ANDERSON: Thank
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46 Discussion a paralytic case. Thi
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48 Discussion + - + + I + - I + + 1
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50 Discussion sages of neurovirulen
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Application of Genetic Markers to D
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Discussion 67 TABLE 1. INCIDENCE OF
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Experimental Studies on Animals wit
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6. DETECTION OF A "NON-DETECTABLE"
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Detection of a "Non-Detectable" Sim
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Discussion 87 Dr. Koprowski's state
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Discussion 89 recognize its effects
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Laboratory Investigations of Attenu
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Discussion 99 In the case of Table
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8. BEHAVIOR OF COLD MUTANTS OF POLI
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Behavior of Cold Mutants of Poliovi
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DISCUSSION CHAIRMAN BURNET: Thank y
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114 Safety-Field Evidence of Safety
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118 S afety-Field Evidence of S af
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122 Discussion 122 Discussion~~~~~~
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10. LABORATORY INVESTIGATIONS OF TH
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126 VIRUS 1 MAhONEY Safety-Field Ev
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128 Safety-Field Evidence óf Safet
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DISCUSSION CHAIRMAN ZHDANOV: This p
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11. EPIDEMIOLOGICAL AND VIROLOGICAL
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12. SPREAD OF A VACCINE STRAIN OF P
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148 Saf ety-Field Evidence of Saf e
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152 Saf ety-Field Evidence of Safet
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DISCUSSION CHAIRMAN ZHDANOV: The pa
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158 Discussion 158 Díscussion~~~~~
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160 Discussion specimens. We were u
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. . . 168 Safety-Field Evidence of
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14. THE CAPACITY OF LIVE ATTENUATED
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176 Saf ety-Field Evidence of Saf e
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... ____ v __ _"_ _. ___.__ __ .,_.
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Field, Laboratory Experiences With
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16. STUDIES ON LIVE POLIOVIRUS VACC
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Studies on Live Poliovirus Vaccine
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Da. HORSTMANN: If I may answer for
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Discussion 205 Discussion 205 tried
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NOTE: The Spanish translation of th
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Vaccination of Pregnant Women and Y
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Development and Persistence of Poli
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Development and Persistence of Poli
Page 250 and 251: Development and Persistence of Poli
Page 258 and 259: Virologic, Serologic Investigations
Page 280 and 281: _ _ _ _ _ _ _ _ Virologic, Serologi
Page 284 and 285: cARE NUC:4I Discussion 267 CUAw # J
Page 286 and 287: Discussion 269 in the investigation
Page 288 and 289: Virological Findings, Antibody Resp
Page 294 and 295: 4. ROUTINE IMMUNIZATION WITH ATTENU
Page 296 and 297: Routine Immunization With Attenuate
Page 298 and 299: Routine Immunization With Attenuate
Page 300: Routine Immunization With Attenuate
Page 305 and 306: 288 Efficacy-Laboratory Evidence 28
Page 307 and 308: 290 Efficacy-Laboratory Evidence TA
Page 311 and 312: 6. VACCINATION OF FULL-TERM INFANTS
Page 313 and 314: 296 296 Efficacy-Laboratory Evidenc
Page 317 and 318: 300 Efflcacy-Laboratory Evidence TA
Page 319 and 320: 7. THE RESPONSE OF NEWBORN INFANTS
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Page 325 and 326: 8. PRELIMINARY REPORT ON THE SUSCEP
Page 327 and 328: 310 310 Efficaey-Laboratory Evidenc
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Page 333 and 334: 316 Efflcacy-Laboratory Evidence 31
Page 335 and 336: 318 TABLE 3. Efficacy-Laboratory Ev
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Page 339 and 340: DISCUSSION CHAIRMAN HILLEBOE: Befor
Page 341 and 342: 324 Discussion INFLUENCES OF ANTIBO
Page 343 and 344: 326 Discussion 326 Discussion Would
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Page 347 and 348: 10. RECENT EXPERIENCE WITH THE LEDE
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334 Efficacy-Laboratory Evidence 10
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336 Efficacy-Laboratory Evidence pr
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338 Efficacy--Laboratory Evidence G
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340 Efficacy-Laboratory Evidence CD
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344 Efficacy-Laboratory Evidence ti
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i . ;; ,---- , , _ ·, ,,, ,, 346 E
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348 Efficacy-Laboratory Evidence ta
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350 Efficacy-Laboratory Evidence TA
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352 Efficacy-Laboratory Evidence mo
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368 Efflcacy-Laboratory Evídence 3
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370 Efficacy-Laboratory Evidence RE
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372 372 Discussion Discussion~~~~~~
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374 Discussion 374 Discussion~~~~~
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384 Effieacy-Laboratory Evidence 38
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15. USE OF SABIN'S LIVE POLIOVIRUS
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388 Efficacy-Laboratory Evidence o
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_ 392 Efficacy-Laboratory Evidence
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402 Efficacy-Laboratory Evidence z
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404 Efficacy-Laboratory Evidence )
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406 Efficacy-Laboratory Evidence c
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408 Efficacy-Laboratory Evidence l)
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DISCUSSION CHAIRMAN LÉPINE: The pa
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412 Discussion tion. I do not see h
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414 Efficacy-Field Evidence ference
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416 Effcacy-Field Evidence TABLE 3.
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418 Efficacy-Field Evidence DAYS OF
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preparation. Large-scale field tria
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422 Efficacy-Field Evidence taneous
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424 Efficacy-Field Evidence TABLE 1
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426 Efficacy-Field Evidence 2048 ,a
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428 Efficacy-Field Evidence 60o S0
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432 Discussion tioned already in th
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Large-Scale Field Trial with Oral C
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18. PRELIMINARY REPORT OF EPIDEMIOL
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Epidemiological Surveillance in Mas
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DISCUSSION CHAIRMAN RHODES: These t
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Discussion 459 -~~~~Dsuso 5 We did
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Discussion 461 logical anomalies of
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Discussion 463 The majority of chil
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case of poliomyelitis, if it was po
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470 Efficacy-Field Evidence 470 Eff
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20. LIVE VIRUS VACCINE STUDIES IN S
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DISCUSSION CHAIRMAN RHODES: These t
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21. MATERIAL ON THE IMMUNOLOGICAL A
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484 Efficacy-Field Evidence 484 Efi
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486 Efficacy-Field Evidence 486 iEf
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488 Efficacy-Field Evidence - TABLE
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494 Efficaey-Field Evidence TABLE 9
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496 Efficaey-Field Evidence TABLE 1
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498 Efficacy-Field Evidence Qo - Co
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500 Etfficacy-Field Evidence 500 Ef
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506 Discussi on hausted the morbidi
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510 Efficacy-Field Evidence b 'r3 `
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512 ol o c,- 4 3- 0 7 Efficacy-Fiel
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514 Efficacy-Field Evidence b, U *
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516 Efficacy-Field Evidence o e 0 1
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518 Efficacy-Field Evidence in the
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520 Efficacy-Field Evidence thing w
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23. VACCINATION AGAINST POLIOMYELIT
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528 Efficacy-Field Evidence MAP 2.
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DISCUSSION CHAIRMAN STUART-HARRIS:
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534 Efficacy-Field Evidence a still
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536 Efficacy-Field Evidence frigera
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538 TABLE 3. Efficacy-Field Evidenc
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540 Efficacy-Field Evidence sented
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544 Efficacy-Field Evidence Antibod
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546 Efficacy-Field Evidence 250t 20
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550 Efficacy-Field Evidence FIGURE
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552 Efficacy-Field Evidence u o o
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-Y 554 Efficacy-Field Evidence TABL
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556 -- Efficacy-Field Evidence 0
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c 558 Efficacy-Field Evidence o z o
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560 Efficacy-Field Evidence Clayton
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562 Efficacy-Field Evidence 2. Triv
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564 Efficacy-Field Evidence and by
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566 Efficacy-Field Evidence establi
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568 Efficacy-Field Evidence Costa R
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570 Efficacy-Fi eld Evidence Two su
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572 Efficacy-Field Evidence o0 u p
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DISCUSSION CHAIRMAN STUART-HARRIS:
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27. LARGE-SCALE PRACTICAL TRIALS AN
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578 Efficacy-Field Evidence some of
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580 Efficacy-Field Evidence vaccine
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582 Efficacy-Field Evidence more th
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584 Efficacy-Field Evidence medical
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586 Efficacy-Field Evidence immuniz
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588 Efficacy-Field Evidence nationa
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DISCUSSION CHAIRMAN VARGAS-MÉNDEZ:
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Discussion 593 -~~~~~isuso 9 a stoo
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Discussion 595 If the chain of tran
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dence of immunization within a few
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Discussion 599 the people in a few
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Summary of the Conference 601 prese
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The occurrence of poliomyelitis in
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INDEX Abad Gómez, Héctor, 369 Abo
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Index 609 Attack rates-continued hi
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Index 611 Chromatography purificati
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Index 613 Dosage-continued statisti
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Index 615 Field trials-continued Le
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Index 617 Human tissue-culture syst
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Index 619 Intestinal tract-continue
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Index 621 Markush, R. E., paper 435
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Index 623 Newborns-continued degree
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Index 625 Poliomyelitis, paralytic-
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Index 627 Reversion dangers of, 485
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Index 629 Spread-continued in the c
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Index 631 Vaccination-continued rep
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Index 633 Vaccine, Attenuated, Triv
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LIVE POLIO IRUS VACCINES

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