LIVE POLIO IRUS VACCINES

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Table of Contents
and
Program of the Conference
Page
List of Participants ............ .... ................................. xi
FIRST SESSION, Monday, 6 June 1960, 9:30 a.m.
Chairman:
DR. GAYLORD W. ANDERSON
INTRODUCTORY REMARKS
Dr. Abraham Horwitz .................... 3
Dr. Raymond D. Ritts ...................................................... 4
TOPIC I.
GENERAL CONSIDERATIONS
The Tin Anniversary of the Development of Live Poliovirus Vaccine-Hilary Koprowski 5
TOPIC II. SAFETY. (A) LABORATORY EVIDENCE OF
ATTENUATION AND SAFETY
1. Problems Associated with Live Poliovirus Vaccine and its Progeny after Multiplication
in Man-Joseph L. Melnick and Matilda Benyesh-Melnick ................. 12
Discussion .............................................................. 28
2. Assessment of Correlation between Certain In vitro Poliovirus Markers and Monkey
Neurovirulence-V. J. Cabasso, E. L. Jungherr, S. Levine, A. W. Moyer, M. Roca-
García, and H. R. Cox ................................................. 31
Discussion ................................................................ 39
3. A Physical Property as a Virus Marker: Difference in Avidity of Cellulose Resin for
Virulent (Mahoney) and Attenuated (LSc, 2ab) Strain of Type 1 Poliovirus-
Horace L. Hodes, Helen D. Zepp, and Eugene A. Ainbender ... ...... .. 41
Discussion ..................................................... .... . ...... 44
SECOND SESSION, Monday, 6 June 1960, 2:00 p.m.
Chairman:
SIR F. MACFARLANE BURNET
TOPIC II. SAFETY. (A) LABORATORY EVIDENCE OF
ATTENUATION AND SAFETY (continuation)
4. The Application of Genetic Markers to the Development and Control of Live Poliovirus
Vaccine-Hilary Koprowski, Richard Carp, T. W. Norton, Barbara Cohen,
and Stanley A. Plotkin ........................ . .. 53
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