LIVE POLIO IRUS VACCINES

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Dr. Edith PETTE Institute for the Research and Multiple Sclerosis Hamburg, Germany of Poliomyelitis Dr. Heinrich PETTE Professor of Neurology Institute for the Research of Poliomyelitis and Multiple Sclerosis Hamburg, Germany Dr. Stanley A. PLOTKIN Epidemic Intelligence Service Officer U.S. Public Health Service, assigned to The Wistar Institute Philadelphia, Pennsylvania, U.S.A. Dr. Konald A. PREM Assistant Professor Department of Obstetrics and Gynecology University of Minnesota School of Medicine Minneapolis, Minnesota, U.S.A. Professor Feliks PRZESMYCKI Professor of Epidemiology of the Medical School, and Director, State Institute of Hygiene Warsaw, Poland Dr. José Manuel QUIRCE Minister of Public Health San José, Costa Rica Dr. Manuel RAMOS ALVAREZ Chief, Virus Laboratory Children's Hospital Mexico, D.F., Mexico Dr. Andrew J. RHODES Director, School of Hygiene University of Toronto Toronto, Ontario, Canada Dr. Frederick C. ROBBINS Professor of Pediatrics Western Reserve University School of Medicine Cleveland, Ohio, U.S.A. Dr. Manuel ROCA-GARCIA Viral and Rickettsial Research Section Lederle Laboratories American Cyanamid Company Pearl River, New York, U.S.A. xiv Dr. Albert B. SABIN Professor of Research Pediatrics University of Cincinnati College of Medicine Cincinnati, Ohio, U.S.A. Dr. Alexis SHELOKOV Director, Middle America Research Unit National Institutes of Health U.S. Public Health Service Balboa Heights, Canal Zone Dr. Vilém SKOVRÁNEK Department of Epidemiology Ministry of Health Prague, Czechoslovakia Dr. Joseph E. SMADEL Associate Director National Institutes of Health Bethesda, Maryland, U.S.A. Professor Anatol A. SMORODINTSEV Chief, Virus Department Institute of Experimental Medicine Academy of Medical Sciences Leningrad, USSR Dr. Fred L. SOPER Director Emeritus of the Pan American Sanitary Bureau 4104 Rosemary Street Chevy Chase, Maryland, U.S.A. Dr. Alex J. STEIGMAN Chairman, Committee on Control of Infectious Diseases American Academy of Pediatrics Louisville, Kentucky, U.S.A. Dr. Charles H. STUART-HARRIS Professor of Medicine University of Sheffield Sheffield, England Dr. Howard TINT Director, Product Development Wyeth Laboratories Philadelphia, Pennsylvania, U.S.A. Dr. John O'Hara TOBIN Biological Standards Control Laboratory Medical Research Council Holly Hill, Hampstead London, England
Dr. C. E. VAN ROOYEN Professor of Bacteriology Dalhousie University School of Medicine Halifax, Nova Scotia, Canada Dr. Oscar VARGAS-MÉNDEZ Director General of Health Ministry of Public Health San José, Costa Rica Dr. Milton V. VELDEE Medical Director (ret.) U.S. Public Health Service Menlo Park, California, U.S.A. Dr. Jacobus D. VERLINDE Professor of Microbiology University of Leiden Faculty of Medicine Leiden, Netherlands Dr. Vladimir VONKA Virus Department Institute of Sera and Vaccines Prague, Czechoslovakia Dr. Marina K. VOROSHILOVA Head, Laboratory of Immunology Institute for Poliomyelitis Research Academy of Medical Sciences Moscow, USSR Dr. William G. WORKMAN Chief, Laboratory of Control Activities Division of Biologics Standards National Institutes of Health Bethesda, Maryland, U.S.A. Professor Victor M. ZHDANOV Academic Secretary Academy of Medical Sciences Moscow, USSR Staff Members of the Pan American Health Organization and the World Health Organization Dr. Juan José ALCOCER, Medical Officer, PAHO/WHO, Guatemala City, Guatemala Dr. Alfredo N. BICA, Chief, Communicable Diseases Branch, PAHO/WHO, Washington, D.C. Dr. Hanna B. DOANY, Virology Consultant, PAHO/WHO, Cali, Colombia Dr. Carlos Luis GONZÁLEZ, Assistant Director, PAHO/WHO, Washington, D.C. Dr. Abraham HORWITZ, Director. PAHO/WHO, Washington, D.C. Dr. Mauricio MARTINS DA SILVA, Poliomyelitis Adviser, Communicable Diseases Branch, PAHO/WHO, Washington, D.C. Dr. Juan A. MONTOYA, Epidemiology Consultant, PAHO/WHO, San José, Costa Rica Dr. Anthony M.-M. PAYNE, Chief Medical Officer, Virus Diseases, WHO, Geneva Dr. Myron E. WEGMAN, Secretary General, PAHO/WHO, Washington, D.C. xv
Page 1 and 2: LIVE POLIO IRUS VACCINES Papers Pre
Page 3 and 4: SECOND INTERNATIONAL CONFERENCE ON
Page 5: Preface The accumulation of informa
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Page 10 and 11: Page 6. Vaccination of Full-Term In
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Page 14 and 15: Dr. Ghislain COURTOIS Director, Pri
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Page 21 and 22: 4 Introductory Remarks 4 Introducto
Page 23 and 24: 6 General Considerations immunity a
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50 Discussion sages of neurovirulen
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Application of Genetic Markers to D
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Discussion 67 TABLE 1. INCIDENCE OF
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Experimental Studies on Animals wit
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6. DETECTION OF A "NON-DETECTABLE"
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Detection of a "Non-Detectable" Sim
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Discussion 87 Dr. Koprowski's state
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Discussion 89 recognize its effects
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Laboratory Investigations of Attenu
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Discussion 99 In the case of Table
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8. BEHAVIOR OF COLD MUTANTS OF POLI
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Behavior of Cold Mutants of Poliovi
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DISCUSSION CHAIRMAN BURNET: Thank y
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114 Safety-Field Evidence of Safety
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118 S afety-Field Evidence of S af
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122 Discussion 122 Discussion~~~~~~
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10. LABORATORY INVESTIGATIONS OF TH
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126 VIRUS 1 MAhONEY Safety-Field Ev
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128 Safety-Field Evidence óf Safet
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DISCUSSION CHAIRMAN ZHDANOV: This p
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11. EPIDEMIOLOGICAL AND VIROLOGICAL
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12. SPREAD OF A VACCINE STRAIN OF P
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148 Saf ety-Field Evidence of Saf e
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152 Saf ety-Field Evidence of Safet
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DISCUSSION CHAIRMAN ZHDANOV: The pa
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158 Discussion 158 Díscussion~~~~~
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160 Discussion specimens. We were u
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. . . 168 Safety-Field Evidence of
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14. THE CAPACITY OF LIVE ATTENUATED
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176 Saf ety-Field Evidence of Saf e
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Field, Laboratory Experiences With
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16. STUDIES ON LIVE POLIOVIRUS VACC
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Studies on Live Poliovirus Vaccine
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Da. HORSTMANN: If I may answer for
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Discussion 205 Discussion 205 tried
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NOTE: The Spanish translation of th
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Vaccination of Pregnant Women and Y
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Development and Persistence of Poli
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Virologic, Serologic Investigations
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_ _ _ _ _ _ _ _ Virologic, Serologi
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cARE NUC:4I Discussion 267 CUAw # J
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Discussion 269 in the investigation
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Virological Findings, Antibody Resp
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4. ROUTINE IMMUNIZATION WITH ATTENU
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Routine Immunization With Attenuate
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Experimental Infectionwith CHATAtte
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Experimental Infection with CHATAtt
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Experimental Infection with CHATAtt
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Vaccination of Full-Term Infants wi
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Response of Newborn Infants to Vacc
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Susceptibility of Newborn Infants t
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9. IMMUNIZATION OF NEWBORN INFANTS
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Immunization of Newborn Infants wit
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Discussion 323 vaccinated siblings
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Discussion 325 Discussion 325 ance
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transplacental antibodies, or antib
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Discussion 329 Discussion 329 born
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Recent Experience with Lederle Triv
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11. FURTHER EXPERIENCES WITH ORAL P
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Further Experiences with Oral Polio
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Minnesota Studies with Oral Poliomy
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13. USE OF ATTENUATED LIVE POLIOVIR
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Use of Attenuated Live Poliovirus V
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Use of Attenuated Live Poliovirus V
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DISCUSSION CHAIRMAN LÉPINE: The tw
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Discussion 373 -~~~~~~ics o 7 domin
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Discussion 375 -~ ~~~~isuso 7 DR. C
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i 14. EFFECTS OF RAPID MASS IMMUNIZ
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Live Poliovirus Immunization-Condit
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Use of Sabin's Live Poliovirus Vacc
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- Use of Sabin's Live Poliovirus Va
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TABLE 14. Use of Sabin's Live Polio
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Discussion 411 DR. ANDERSON: My que
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Course of Mass Immunization in USSR
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, _ _ Course of Mass Immunization i
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DISCUSSION CHAIRMAN LÉPINE: Thank
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Discussion 431 DR. STUART-HARRIS: I
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436 Efficacy-Field Evidence TABLE 1
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438 Efficacy-Field Evidence Adminis
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444 Effcaey-Field Evidence 44 Efiay
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446 Efficacy-Field Evidence 446 Eff
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448 Efficacy-Field Evidence 448 lEf
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450 Efficacy-Field Evidence m Co 0
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452 Efficacy-Field Evidence ] ~~ ~
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454 Efficacy-Field Evidence It is n
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456 Efficacy-Field Evidence M.G. C
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460 460 Discussion Discussion~~~~~~
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462 Discussion one was sponsored by
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Vaccination with CHAT Strain Type 1
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Live Virus Vaccine Studies in South
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Discussion 481 the ages of the five
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Immunological and Epidemiological E
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DISCUSSION CHAIRMAN STUART-HARRIS:
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Further Observations on First Field
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Further Observations Qn First Field
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Further Observations on First FielJ
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Poliomyelitis Vaccination in Poland
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24. A SMALL-SCALE TRIAL WITH LIVE P
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Live Poliomyelitis Vaccine-Small-Sc
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25. VACCINATION AND CHALLENGE-POLIO
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Vaccination and Challenge-Poliomyel
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26. VACCINATION WITH ATTENUATED POL
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Vaccination with Attenuated Poliovi
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Discussion 575 ence last year. The
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Large-Scale Practical Trials, Use o
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594 Discussion 594 Disenísion ~ ~
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596 Discussion 596 Díscussion~~~~~
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598 Discussion 598 Discussion high
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iiiii iirrrimrmiriiiilllniririiiiii
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602 Summary of the Conference 602 S
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Appendix The following letter was r
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608 Index Antibodies-continued half
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610 Index Bulychev, N. P., paper, 4
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612 Index Coxsackie--continued B-3
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614 Index Epidemics-continued intro
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616 Index Genetic stability-continu
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618 Index Infants-continued source
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620 Index Laboratory surveillance d
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622 Index Monkey neurovirulence, 95
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624 Index pH neutralization test, 6
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626 Index Poliomyelitis virus-conti
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628 Index Serological response-cont
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630 Index T marker-continued T- str
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632 Index Vaccine, Attenuated-conti
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634 Index Virus isolations and anti
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