LIVE POLIO IRUS VACCINES

Virological Findings, Antibody Response of Infants Fed Multiple, Oral Vaccine 273
TABLE 3. CORRELATION OF VIROLOGICAL AND
SEROLOGICAL FINDINGS AFTER FEEDING ORAL
Ii
I vARO¿OC/C»¿
POLIOMYELITIS
Ar/,VD/Mi
T oNT 3 /o 3
i MVEo I 3
VACCINE
T, T , 11»Ta, X. 1
, _@
_1 i 1 3_+l
L I I ' , nl
0 ' (5)
sponded serologically to a single Type 1 or 3,
respectively.
Table 4 shows virological findings and antibody
titers in the post-feeding specimens of 14
"triple negative" children, i.e. children without
maternal antibody. Attention is called to child
76, the only infant who excreted poliovirus Type
2 and showed a corresponding rise in antibody
titer. In the other infants, high antibody titers
were obtained to polioviruses isolated from their
TABLE 4. POLIOVIRUS ISOLATIONS AND ANTI-
BODY RESPONSE IN "TRIPLE NEGATIVE" INFANTS,
3-4 MONTHS OLD, AFTER FEEDING ORAL POLIO-
MYELITIS VACCINE
No PRE-FEEDING ENTEROVIRUSES FOUND
Cl/.,1D A
/3
56
63"
69
74
76
/02
/03
/06
//4
//5
/43
/05
//6
Po¿/ov/l..uv
TvPt',rD
/dOL fT Z&
- ... __!
774,yo 73
;. íJxoT 3
T 3
ir/RoYV TT/R To
1i
rT T2 |T3 1
64 0 64
64 1 256
O 0 d4,i
256 0 !/024
/6 0 64
64 641 256
64 0 2561
/6 0 /61
256 o 64
/6 0 /1 6
4 0 64!
o o 64!
T 3
T = type.
·- Type 1 was isolated in one stool specimen, Type
3 was isolated from all 4 stool specimens.
stool specimens, again indicating adequate antibody
responses to the types of poliovirus isolated
from their stool specimens.
TABLE 5. POLIOVIRUS ISOLATIONS AND ANTI-
BODY RESPONSE IN INFANTS, 3-4 MONTHS OLD,
WITH MATERNAL ANTIBODY TITER OF 1:16 TO
1:64 AFTER FEEDING ORAL POLIOMYELITIS
VACCINE
C7/7D Ne
_/
53
95
99
T, AND T3
T3
T3
fJAz/~ov r/reR ro
T, T 3-1
64L 256
64 64
In Table 5 virological and serological results
are shown in seven infants whose pre-feeding sera
showed the presence of antibodies in titers of
1:16 to 1:64 to both Types 1 and 3 poliovirus.
The relatively high antibody titers to the
homologous types of polioviruses excreted, demonstrate
little or no effect of maternal antibodies
on both virus excretion and the resulting antibody
titers.
Of approximately 153 infants, one to four
months old, 16 per cent showed the presence of
an enterovirus in their pre-feeding stool specimens.
Complete results of the virus isolations in
pre- and post-feeding stool specimens, as well
as antibody titers on pre- and post-feeding blood
samples, have thus far been obtained on 14 of
these infants.
Tables 6a and 6b summarize the virological
and serological findings. In Table 6a are included
seven infants from whose pre-feeding stool
specimens enteroviruses were isolated and identified
as Coxsackie B5 and A9, and ECHO 2 and 14.
Children Nos. 40 and 8 excreted Coxsackie B5
in both the pre- and post-feeding stools. This did
not seem to interfere with the multiplication and
excretion of the vaccine polioviruses, nor did it
affect the antibody response which was high to
both poliovirus Types 1 and 3 excreted. Infant
No. 91 did not show the Coxsackie strain in the