LIVE POLIO IRUS VACCINES

264
Effcaey-Laboratory Evidence
264 Efficacy-Laboratory Evidence
The children who had been vaccinated twice
with trivalent live vaccine in the summer of
Type 2 antibody in 100 per cent and Type 3
antibody in 76.2 per cent of children without
1959, received Type 1 vaccine incorporated into previous corresponding antibody (Fig. 8). At
dragée-candy in February 1960; and in March
1960, they received trivalent vaccine in dragéecandy.
Virologic investigation of fecal specimens
after these two additional feedings has not yet
the same time, increase of titers to all three types
was observed (Fig. 9).
Thus, in vaccination of younger children with
trivalent vaccine, best results were obtained with
been completed. Serological investigation of regard to Type 2. Therefore, in order to avoid
children from chidren's homes L. and R. two
weeks after final feeding showed that 75 per cent
of children with antibody deficiency developed antibody
to all three types of poliomyelitis virus.
Type 1 antibody developed in 87.2 per cent,
interfering effect of Type 2 virus, primary vaccination
should be carried out with Types 1 and 3
viruses, and then trivalent mixture may be given.
For revaccinations, trivalent live vaccine may be
used preferably in the form of dragée-candy.
LOG. TCD 5/G.
FIG. 12.
Examples of interaction between vaccine strains and non-polio enteroviruses on two feedings
with trivalent live vaccine.