LIVE POLIO IRUS VACCINES

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Vaccination of Full-Term Infants with Attenuated Polioviruses 295 TABLE 1. TABLE 2. GEOMETRIC POLIOVIRUS MEAN HALF-LIVES OF ANTIBODY Virus Number nf Geometric Mean Type Determinations 1alf-Life (Days) 1 9 17 2 17 18 3 9 18 All 35 18 Arithmetic Mean = 19 Standard Deviation = + O AGE AT VACCINATION IN RELATION TO INTESTINAL INFECTION WITH ATTENUATED POLIO- VIRUSES Age Positive Intestinal Infections (Days) Ratio Per Cent TABLE 4. INTESTINAL INFECTION IN RELATION TO LEVEL OF TRANSPLACENTALLY ACQUIRED ANTI- BODIES IN INFANTS LESS THAN 70 DAYS OLD Homotypic Antibody Infections Established Titer at Vacc. Ratio Per Cent 512-256 9/9 100 128-64 14/21 67 32-16 22/25 80 8-
296 296 Efficacy-Laboratory Evidence Efficacy-Laboratory Evidence TABLE 6. ANTIBODY LEVELS AT INTERVALS AFTER VACCINATION OF INFANTS IN WHOM INTESTINAL INFECTION DEVELOPED Age When Mean Pre- Mean Postvaccination Antibody Titers* Vaccinated vaccination (Days After Vaccination) (days) Antibody 21 - 45 46 - 75 '7 - 135 Titer* 0 - 7 30 (16)** 21 (10) 9 (10) 14 (14) 8 - 35 24 (17) 15 (11) 15 (16) 34 (17) 36 - 70 10 (18) 17 (27) 54 (17) 128 (4) 71 - 140 7 (10) 151 (21) 03 (5) 51 (7) Entire Group 16 (61) 29 (69) 26 (48) 31 (42) * Geometric means; reciprocals of serum dilution. Titer of
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LIVE POLIO IRUS VACCINES Papers Pre
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SECOND INTERNATIONAL CONFERENCE ON
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Preface The accumulation of informa
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Page Discussion .......... .......
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Page 6. Vaccination of Full-Term In
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Page 23. Vaccination against Poliom
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Dr. Ghislain COURTOIS Director, Pri
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Dr. Edith PETTE Institute for the R
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4 Introductory Remarks 4 Introducto
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6 General Considerations immunity a
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8 General Considerations from accep
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10 General Considerations 10 Genera
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14 Safety-Laboratory Evidence of At
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- 26 Safety-Laboratory Evidence of
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DISCUSSION CHAIRMAN ANDERSON: There
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30 Discussion CHAIRMAN ANDERSON: Th
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32 TABLE 1. Safety-Laboratory Evide
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40 Discussion Of the 22 monkeys inf
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DISCUSSION CHAIRMAN ANDERSON: Thank
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46 Discussion a paralytic case. Thi
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48 Discussion + - + + I + - I + + 1
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50 Discussion sages of neurovirulen
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Application of Genetic Markers to D
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Discussion 67 TABLE 1. INCIDENCE OF
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Experimental Studies on Animals wit
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6. DETECTION OF A "NON-DETECTABLE"
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Detection of a "Non-Detectable" Sim
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Discussion 87 Dr. Koprowski's state
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Discussion 89 recognize its effects
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Laboratory Investigations of Attenu
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Discussion 99 In the case of Table
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8. BEHAVIOR OF COLD MUTANTS OF POLI
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Behavior of Cold Mutants of Poliovi
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DISCUSSION CHAIRMAN BURNET: Thank y
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114 Safety-Field Evidence of Safety
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118 S afety-Field Evidence of S af
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122 Discussion 122 Discussion~~~~~~
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10. LABORATORY INVESTIGATIONS OF TH
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126 VIRUS 1 MAhONEY Safety-Field Ev
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128 Safety-Field Evidence óf Safet
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DISCUSSION CHAIRMAN ZHDANOV: This p
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11. EPIDEMIOLOGICAL AND VIROLOGICAL
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12. SPREAD OF A VACCINE STRAIN OF P
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148 Saf ety-Field Evidence of Saf e
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152 Saf ety-Field Evidence of Safet
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DISCUSSION CHAIRMAN ZHDANOV: The pa
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158 Discussion 158 Díscussion~~~~~
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160 Discussion specimens. We were u
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. . . 168 Safety-Field Evidence of
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14. THE CAPACITY OF LIVE ATTENUATED
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176 Saf ety-Field Evidence of Saf e
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Field, Laboratory Experiences With
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16. STUDIES ON LIVE POLIOVIRUS VACC
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Studies on Live Poliovirus Vaccine
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Da. HORSTMANN: If I may answer for
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Discussion 205 Discussion 205 tried
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NOTE: The Spanish translation of th
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Vaccination of Pregnant Women and Y
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Development and Persistence of Poli
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Virologic, Serologic Investigations
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Virologic, Serologic Investigations
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Page 284 and 285: cARE NUC:4I Discussion 267 CUAw # J
Page 286 and 287: Discussion 269 in the investigation
Page 288 and 289: Virological Findings, Antibody Resp
Page 294 and 295: 4. ROUTINE IMMUNIZATION WITH ATTENU
Page 296 and 297: Routine Immunization With Attenuate
Page 298 and 299: Routine Immunization With Attenuate
Page 300: Routine Immunization With Attenuate
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Page 306 and 307: Experimental Infectionwith CHATAtte
Page 308 and 309: Experimental Infection with CHATAtt
Page 310 and 311: Experimental Infection with CHATAtt
Page 314 and 315: Vaccination of Full-Term Infants wi
Page 320 and 321: Response of Newborn Infants to Vacc
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Page 332 and 333: 9. IMMUNIZATION OF NEWBORN INFANTS
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Page 348 and 349: Recent Experience with Lederle Triv
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Page 360 and 361: Further Experiences with Oral Polio
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Further Experiences with Oral Polio
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Minnesota Studies with Oral Poliomy
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13. USE OF ATTENUATED LIVE POLIOVIR
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Use of Attenuated Live Poliovirus V
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Use of Attenuated Live Poliovirus V
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DISCUSSION CHAIRMAN LÉPINE: The tw
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Discussion 373 -~~~~~~ics o 7 domin
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Discussion 375 -~ ~~~~isuso 7 DR. C
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i 14. EFFECTS OF RAPID MASS IMMUNIZ
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Live Poliovirus Immunization-Condit
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Use of Sabin's Live Poliovirus Vacc
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- Use of Sabin's Live Poliovirus Va
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TABLE 14. Use of Sabin's Live Polio
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Discussion 411 DR. ANDERSON: My que
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Course of Mass Immunization in USSR
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, _ _ Course of Mass Immunization i
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DISCUSSION CHAIRMAN LÉPINE: Thank
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Discussion 431 DR. STUART-HARRIS: I
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436 Efficacy-Field Evidence TABLE 1
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438 Efficacy-Field Evidence Adminis
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444 Effcaey-Field Evidence 44 Efiay
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446 Efficacy-Field Evidence 446 Eff
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448 Efficacy-Field Evidence 448 lEf
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450 Efficacy-Field Evidence m Co 0
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452 Efficacy-Field Evidence ] ~~ ~
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454 Efficacy-Field Evidence It is n
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456 Efficacy-Field Evidence M.G. C
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460 460 Discussion Discussion~~~~~~
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462 Discussion one was sponsored by
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Vaccination with CHAT Strain Type 1
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Live Virus Vaccine Studies in South
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Discussion 481 the ages of the five
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Immunological and Epidemiological E
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DISCUSSION CHAIRMAN STUART-HARRIS:
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Further Observations on First Field
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Further Observations Qn First Field
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Further Observations on First FielJ
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Poliomyelitis Vaccination in Poland
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24. A SMALL-SCALE TRIAL WITH LIVE P
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Live Poliomyelitis Vaccine-Small-Sc
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25. VACCINATION AND CHALLENGE-POLIO
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Vaccination and Challenge-Poliomyel
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26. VACCINATION WITH ATTENUATED POL
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Vaccination with Attenuated Poliovi
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Discussion 575 ence last year. The
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Large-Scale Practical Trials, Use o
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594 Discussion 594 Disenísion ~ ~
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596 Discussion 596 Díscussion~~~~~
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598 Discussion 598 Discussion high
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602 Summary of the Conference 602 S
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Appendix The following letter was r
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608 Index Antibodies-continued half
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610 Index Bulychev, N. P., paper, 4
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612 Index Coxsackie--continued B-3
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614 Index Epidemics-continued intro
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616 Index Genetic stability-continu
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618 Index Infants-continued source
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620 Index Laboratory surveillance d
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622 Index Monkey neurovirulence, 95
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624 Index pH neutralization test, 6
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626 Index Poliomyelitis virus-conti
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628 Index Serological response-cont
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630 Index T marker-continued T- str
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632 Index Vaccine, Attenuated-conti
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634 Index Virus isolations and anti
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LIVE POLIO IRUS VACCINES

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