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LIVE POLIO IRUS VACCINES

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612 Index<br />

Coxsackie--continued<br />

B-3<br />

isolated Costa Rica, 575<br />

restricted to Morgan City, La., 151<br />

B-5<br />

isolated from infant, 288<br />

restricted to Franklin, La., 151<br />

CPE test, see Cytopathogenic effect neutralization<br />

test<br />

Crossley, Methyl I., paper 435-444; 456<br />

Cuba<br />

children from institutions and camps, 331<br />

field trial, 365-370<br />

Cynomolgus monkeys (Macaca irus phillipinensis)<br />

inapparent virus infection detected in green-monkey-kidney,<br />

85<br />

in IM vaccine tests, technique, 90<br />

virilence test, IT inoculation, 536<br />

Cystine requirements, of virus, 47<br />

Cytomegalic inclusion<br />

SA-VI (salivary gland disease), 85<br />

Cytopathogenic agents<br />

identified by neutralization tesis, 241<br />

not neutralized by poliovirus antisera, 554<br />

Cytopathogenic effect, 359<br />

at various incubation temperatures, 103<br />

classification of simian viruses based on, 79<br />

of vacuolating agent, 88<br />

Cytopathogenic neutralization test, 243<br />

antibody determination, 439<br />

compared to antigenic differentiation test, 160<br />

least sensitive for detecting antibody response, 237<br />

measures higli-avidity antiliody, 121, 228<br />

pH test compared, 159, 228, 268<br />

results lower than pH and ITT tests, 231<br />

Czechoslovakia<br />

field trial, 507-521<br />

increased morbidity, Slovakia, 510, 532<br />

Sabin vaccine tested, 580<br />

Soviet Union furnished vaccines, 419, 582<br />

spread studies, 517<br />

viremia after Type 1, 371<br />

d markers<br />

and covariation, 49<br />

correlation with T character and monkey neurovirulence,<br />

12-25, 36<br />

criteria for vaccine, 31<br />

d- to d+- reversion and T marker, 16<br />

discrepancy, Type 1 strain, 33<br />

excreted virus was d-, 122<br />

for identification of isolates, 199<br />

identification of strains, 480<br />

mechanisms of reaction, 44<br />

not correlated with monkey neurovirulence, 31, 34<br />

of homotypic polio excreted fronm vaccinated children,<br />

16<br />

related to T marker. 189<br />

relation to Lederle vaccine, 33<br />

value not definitely established, 37<br />

Dade County, Florida<br />

field trial, 435-444, 445-456<br />

Dade County, Florida-continued<br />

morbidity increase in second week after feeding,<br />

457<br />

paralytic cases, 1960, 447<br />

Type 1, 2, 3 specimens, 124<br />

Dade County, Florida, Department of Public Health,<br />

436<br />

reports of public reactions, 448<br />

staff described, 446<br />

surveillance of cases, 457<br />

Dade County, Florida, Medical Association, 436<br />

Dade County, Florida, Osteopathic Medical Association,<br />

436<br />

Dade County, Florida, School Board, 436<br />

Dali, Salvador<br />

portraiture analogy, 5<br />

Dancis, Dr. - 328<br />

Dane, D. S., 7<br />

da Silva, M. Martins, see Martins da Silva, M.<br />

Davidenkova, E. F., 482<br />

DEAE column, see Diethylaminoethyl cellulose resin<br />

ion-exchange column<br />

Des Moines, Iowa<br />

high attack rate in iinvaccinated, 575<br />

Deuterium oxide (DO)<br />

effect on plating efficiency, 62, 63<br />

Dick, George W. A., 7, 66, 136, 156, 159, 202-203,<br />

205, 480, 595, 598<br />

Diet<br />

and physiological state of digestive tract, 339<br />

Diethylaminocthyl celliilose resin ion-exchange column<br />

from concentration of virus stool samples, 133<br />

pattern of virus elution, 41-42<br />

Differential growth, see MS marker<br />

Diphtheria<br />

compulsory immunization, 497<br />

eventual eradication, 603<br />

fatality in 9-month vaccinee, 197<br />

Diphtheria antigen<br />

with polio, response of infants, 328<br />

Diseases<br />

in Cincinnati, listed, 593<br />

in Minnesota community, listed, 462<br />

Dixon, Dr. - 294<br />

DNA genetics<br />

classic patterns not applicab!le to RNA viruses, 190<br />

Doany, H., paper 561-573; 575<br />

Dobrova, 1. N., paper 413-428; 418, 240, 246, 249<br />

Dobrowolska, IT., paper, 522-531<br />

Dog-kidney tissue cultures<br />

contain virus resembling distemper, 86<br />

Dominance<br />

increased dosage does not overcome, 117<br />

Type 3 poliovirus, 181<br />

Dosage<br />

and degree of infectiousness, 117, 296<br />

and interference, 156, 275<br />

and resistance of newborn, 6, 218<br />

form no correlation to time of feeding and antibody<br />

response, 359<br />

no marked effect on infection or antibody response,<br />

296

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