LIVE POLIO IRUS VACCINES

524 Efficacy-Field Evidence
TABLE 3. INTRACEREBRAL INOCULATION OF MONKEYS WITH Fox STRAIN
REACTION OF MONIKEYS
BATCH OF VACCINE
DILUTION OF VACCINE
AND REACTION
100 10-1
CLINICAL HISTOPATHOLOGIC CLINICAL HISTOPATHOLOGIC
SIGNS LESIONS SIGNS LESIONS
WF X 0/9 0/9*
WF X 0/5 0/5 0/5 1/5
Total 0/14 0/14 0/5 1/5
* One questionable lesion.
TABLE 4. INTRASPINAL INOCULATION OF MONKEYS WITH FOX STRAIN POLIO VACCINE
.... Diluti
of oVaceaine aid Reaétion
Batch of 100 1 102 10-3
Vaccine Clin. Hist. Clin. Hist. Clin. Hist. Clin. Hist.
Signs Lesions Siens Lesions Signs Lesions Signs Lesions
WF X 2/5* 2/5 0/5* 0/5
WF X 0/5 2/5 1/5 3/5 1/5 1/5 0/5 1/5
Total 2/10 4/10 1/10 3/10 1/5 1/5 0/5 1/5
* Two others had doubtful signs.
Summary:
Doubtful clinical signs 4/30
Typical clinical signs 3/30
Histopathological changes 9/30
vaccination indicated that, with the exception of
three children, no child in the group had antibodies
to all three types of poliovirus.
The antibody concentration in two children
amounted to 1:8 for Types 1 and 3, and 1:4
for Type 2. In a third child, the concentration
of antibodies to Type 1 only was 1:8.
The results of the blood studies made after
vaccination are given in Tables 6 and 7.
As the tables show, the antibodies against
Type 1 increased maximally after 110 days, No
antibodies were detected in 16 per cent of the
children; in 84 per cent, however, the presence
of antibodies was proved. In 72 per cent of the
children, antibodies were present in concentrations
of 1:16 to 1:1024.
It should be added that the level of antibodies
showed variations, or even a decrease, after 30
and 60 days. The highest percentage of positive
results for Type 3 virus was obtained after 80
days. All the sera investigated showed titers
from 1:64 to 1:2048.