LIVE POLIO IRUS VACCINES

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TníTmmnTmmTITTrmlrmnrm SECOND SESSION MONDAY, 6 JUNE 1960, 2:00 p.m. mrmmmmmmmmmmimiimimiii iiiiimm iimimriniinii n iiiiniiiiiiiiinimiiiniiriimiiriin Chairman SIR F. MACFARLANE BURNET Director, Walter and Eliza Hall Institute of' Medical Research Melbourne, Australia TOPIC II. SAFETY. (A) LABORATORY EVIDENCE OF ATTENUATION AND SAFETY (continuation) Presentation of Papers by: Dr. Hilary Koprowski (DISCUSSION) Dr. H. Pette Dr. Maurice R. Hilleman (DISCUSSION) Dr. Ruth L. Kirschstein (DISCUSSION) Dr. Albert B. Sabin (DISCUSSION ) 51
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LIVE POLIO IRUS VACCINES Papers Pre
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SECOND INTERNATIONAL CONFERENCE ON
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Preface The accumulation of informa
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Page Discussion .......... .......
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Page 6. Vaccination of Full-Term In
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Page 23. Vaccination against Poliom
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Dr. Ghislain COURTOIS Director, Pri
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Dr. Edith PETTE Institute for the R
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Page 21 and 22: 4 Introductory Remarks 4 Introducto
Page 23 and 24: 6 General Considerations immunity a
Page 25 and 26: 8 General Considerations from accep
Page 27 and 28: 10 General Considerations 10 Genera
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Page 31 and 32: 14 Safety-Laboratory Evidence of At
Page 43 and 44: - 26 Safety-Laboratory Evidence of
Page 45 and 46: DISCUSSION CHAIRMAN ANDERSON: There
Page 47 and 48: 30 Discussion CHAIRMAN ANDERSON: Th
Page 49 and 50: 32 TABLE 1. Safety-Laboratory Evide
Page 57 and 58: 40 Discussion Of the 22 monkeys inf
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Page 63 and 64: 46 Discussion a paralytic case. Thi
Page 65 and 66: 48 Discussion + - + + I + - I + + 1
Page 67: 50 Discussion sages of neurovirulen
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Page 105 and 106: 88 88 Discussion Discussion~~~~~~~~
Page 107 and 108: 7. LABORATORY INVESTIGATIONS OF THR
Page 115 and 116: DISCUSSION CHAIRMAN BURNET: Thank y
Page 117 and 118: 100 Discussion in his hands and we
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102 Safety-Laboratory Evidence of A
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110 Discussion said that the real p
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nTIITTrTTrmTmmrmTm TOPIC II. SAFETY
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Effectiveness of Trivalent Vaccine
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DISCUSSION CHAIRMAN ZHDANOV: Thank
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who had no antibody at all, as demo
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Laboratory Investigations of Attenu
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DR. BARON: When we come to the prob
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Epidemiological, Virological Survey
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DISCUSSION CHAIRMAN ZHDANOV: This p
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Spread of Vaccine Strain of Poliovi
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Discussion 157 Discussion 157 One o
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Discussion 159 Discussion 159 ence
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13. MINNESOTA STUDIES WITH ORAL POL
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Minnesota Studies With Oral Poliomy
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Capacity of Live Attenuated Poliovi
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I TTmTIIITITIT?~~~~~~~~~~T~~~TTTT~~
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188 Safety-Field Evidence of Safety
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190 Safety-F'ield Evidence of Safet
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vaccine combined in a mixture conta
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DISCUSSION CHAIRMAN GEAR: Thank you
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. _ 204 Discussion I__ _ 1 CC w 4CC
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206 206 Discussion Discussion We kn
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216 216 Safety-Field Evidence of Sa
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224 Saf etv-Field Evidence of Saf e
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The authors wish to express their a
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IIIIIII1I1)1III1II111111:l lrmillll
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- 230 Efficacy-Laboratory Evidence
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232 Efficacv-Laboratory Evidence l2
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234 Efficacy-Laboratory Evidence 40
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236 Efflcacy-Laboratory Evidence 23
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2. VIROLOGIC AND SEROLOGIC INVESTIG
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242 Efficacy-Laboratory Evidence ca
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244 Efficacy-Laboratory Evidence Z
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246 Efficacy-Laboratory Evidence TA
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250 Efficacy-Laboratory Evidence LO
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254 TABLE 21. Efficacy-Laboratory E
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256 Efficacy-Laboratory Evidence QC
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258 Efficacy-Laboratory Evidence Is
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260 Efficacy-Laboratory Evidence o
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264 Effcaey-Laboratory Evidence 264
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DISCUSSION CHAIRMAN GEAR: The last
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268 Discussion " I10,00 1-- , 2,000
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3. VIROLOGICAL FINDINGS AND ANTIBOD
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278 Efficacy-Laboratory Evidence sq
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280 Efficacy-Laboratory Evidence Po
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282 Efficacy-Laboratory Evidence to
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_____~~~~~~~~~~~~~~~~~~~~~~ FIFTH S
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6. VACCINATION OF FULL-TERM INFANTS
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296 296 Efficacy-Laboratory Evidenc
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300 Efflcacy-Laboratory Evidence TA
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7. THE RESPONSE OF NEWBORN INFANTS
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8. PRELIMINARY REPORT ON THE SUSCEP
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310 310 Efficaey-Laboratory Evidenc
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312 Efficacy-Laboratory Evidence ch
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314 314 Efficacy-Laboratory Evidenc
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318 TABLE 3. Efficacy-Laboratory Ev
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320 Efficacy-Laboratory Evidence (u
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DISCUSSION CHAIRMAN HILLEBOE: Befor
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324 Discussion INFLUENCES OF ANTIBO
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326 Discussion 326 Discussion Would
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328 Discussion if we give the Black
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10. RECENT EXPERIENCE WITH THE LEDE
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332 Efficacy-Laboratory Evidence O/
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336 Efficacy-Laboratory Evidence pr
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338 Efficacy--Laboratory Evidence G
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340 Efficacy-Laboratory Evidence CD
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344 Efficacy-Laboratory Evidence ti
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i . ;; ,---- , , _ ·, ,,, ,, 346 E
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348 Efficacy-Laboratory Evidence ta
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352 Efficacy-Laboratory Evidence mo
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368 Efflcacy-Laboratory Evídence 3
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370 Efficacy-Laboratory Evidence RE
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372 372 Discussion Discussion~~~~~~
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374 Discussion 374 Discussion~~~~~
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376 Discussion 376 Discussion~~~~~~
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384 Effieacy-Laboratory Evidence 38
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15. USE OF SABIN'S LIVE POLIOVIRUS
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388 Efficacy-Laboratory Evidence o
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_ 392 Efficacy-Laboratory Evidence
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402 Efficacy-Laboratory Evidence z
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404 Efficacy-Laboratory Evidence )
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406 Efficacy-Laboratory Evidence c
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408 Efficacy-Laboratory Evidence l)
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DISCUSSION CHAIRMAN LÉPINE: The pa
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412 Discussion tion. I do not see h
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414 Efficacy-Field Evidence ference
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416 Effcacy-Field Evidence TABLE 3.
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418 Efficacy-Field Evidence DAYS OF
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preparation. Large-scale field tria
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422 Efficacy-Field Evidence taneous
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424 Efficacy-Field Evidence TABLE 1
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426 Efficacy-Field Evidence 2048 ,a
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428 Efficacy-Field Evidence 60o S0
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430 Discussion 430 Discussion~~~~~~
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432 Discussion tioned already in th
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Large-Scale Field Trial with Oral C
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18. PRELIMINARY REPORT OF EPIDEMIOL
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Epidemiological Surveillance in Mas
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DISCUSSION CHAIRMAN RHODES: These t
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Discussion 459 -~~~~Dsuso 5 We did
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Discussion 461 logical anomalies of
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Discussion 463 The majority of chil
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case of poliomyelitis, if it was po
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470 Efficacy-Field Evidence 470 Eff
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20. LIVE VIRUS VACCINE STUDIES IN S
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DISCUSSION CHAIRMAN RHODES: These t
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21. MATERIAL ON THE IMMUNOLOGICAL A
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484 Efficacy-Field Evidence 484 Efi
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486 Efficacy-Field Evidence 486 iEf
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488 Efficacy-Field Evidence - TABLE
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494 Efficaey-Field Evidence TABLE 9
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496 Efficaey-Field Evidence TABLE 1
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498 Efficacy-Field Evidence Qo - Co
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500 Etfficacy-Field Evidence 500 Ef
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506 Discussi on hausted the morbidi
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510 Efficacy-Field Evidence b 'r3 `
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512 ol o c,- 4 3- 0 7 Efficacy-Fiel
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514 Efficacy-Field Evidence b, U *
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516 Efficacy-Field Evidence o e 0 1
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518 Efficacy-Field Evidence in the
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520 Efficacy-Field Evidence thing w
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23. VACCINATION AGAINST POLIOMYELIT
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528 Efficacy-Field Evidence MAP 2.
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DISCUSSION CHAIRMAN STUART-HARRIS:
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534 Efficacy-Field Evidence a still
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536 Efficacy-Field Evidence frigera
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538 TABLE 3. Efficacy-Field Evidenc
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540 Efficacy-Field Evidence sented
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544 Efficacy-Field Evidence Antibod
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546 Efficacy-Field Evidence 250t 20
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550 Efficacy-Field Evidence FIGURE
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552 Efficacy-Field Evidence u o o
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-Y 554 Efficacy-Field Evidence TABL
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556 -- Efficacy-Field Evidence 0
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c 558 Efficacy-Field Evidence o z o
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560 Efficacy-Field Evidence Clayton
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562 Efficacy-Field Evidence 2. Triv
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564 Efficacy-Field Evidence and by
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566 Efficacy-Field Evidence establi
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568 Efficacy-Field Evidence Costa R
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570 Efficacy-Fi eld Evidence Two su
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572 Efficacy-Field Evidence o0 u p
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DISCUSSION CHAIRMAN STUART-HARRIS:
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27. LARGE-SCALE PRACTICAL TRIALS AN
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578 Efficacy-Field Evidence some of
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580 Efficacy-Field Evidence vaccine
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582 Efficacy-Field Evidence more th
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584 Efficacy-Field Evidence medical
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586 Efficacy-Field Evidence immuniz
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588 Efficacy-Field Evidence nationa
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DISCUSSION CHAIRMAN VARGAS-MÉNDEZ:
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Discussion 593 -~~~~~isuso 9 a stoo
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Discussion 595 If the chain of tran
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dence of immunization within a few
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Discussion 599 the people in a few
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Summary of the Conference 601 prese
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The occurrence of poliomyelitis in
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INDEX Abad Gómez, Héctor, 369 Abo
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Index 609 Attack rates-continued hi
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Index 611 Chromatography purificati
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Index 613 Dosage-continued statisti
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Index 615 Field trials-continued Le
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Index 617 Human tissue-culture syst
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Index 619 Intestinal tract-continue
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Index 621 Markush, R. E., paper 435
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Index 623 Newborns-continued degree
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Index 625 Poliomyelitis, paralytic-
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Index 627 Reversion dangers of, 485
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Index 629 Spread-continued in the c
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Index 631 Vaccination-continued rep
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Index 633 Vaccine, Attenuated, Triv
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LIVE POLIO IRUS VACCINES

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