LIVE POLIO IRUS VACCINES

318
TABLE 3.
Efficacy-Laboratory Evidence
EXTENT OF POLIOVIRUS MULTIPLICATION AT INDICATED TIME AFTER SINGLE FEEDING OF
UNDILUTED TYPE 1 OR TRIVALENT VACCINE
DAY STOOL
OBTAINED
LOG 10 TCD50/Gm. VIRUS IN STOOLS OF INFANTS
1
FED TYPE I ONLY FED TYPES I + II + III
2 3. 2 (II)
3 < 0.8 3. 2 (11)
4 3.2 4.2 4.7 4.7 (11)
5 3. Z2 3.7 4. Z2 4.7 < 0.8 2.2 (1) 3. 2 (1+II) 5.2 (I+I1)
6 < 0.8 6. (11)
7 4. 2 (II)
8 4.2
14 5. 2 (I)
(II) - Type 2 Poliovirus.
TABLE 4.
DECLINE OF 54 PASSIVE POLIOVIRUS NEUTRALIZING ANTIBODY TITERS IN 19 UNVACCINATED
INFANTS FROM BIRTH TO THREE MONTHS
ANTIBODY
LEVEL IN
CORD BLOOD
No. OF
TITERS*
ANTIBODY TITERS OBSERVED AT THREE MONTHS
FOLD-DECLINE
IN TITER
1024
512
256
1
4
9
256 4
128, 128, 64, 64 4-8
64, 32, 16, 16, 16, 16, 16, 16,