LIVE POLIO IRUS VACCINES

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Dr. Ghislain COURTOIS Director, Princess Astrid Institute of Tropical Medicine Leopoldville, Belgian Congo Dr. Herald R. COX Director of Virus Research Lederle Laboratories American Cyanamid Company Pearl River, New York, U.S.A. Dr. James G. CRAWFORD Charles Pfizer and Company Terre Haute, Indiana, U.S.A. Dr. George W. A. DICK Professor of Microbiology The Queen's University of Belfast Belfast, United Kingdom of Great Britain and Northern Ireland Dr. Renato DULBECCO Professor of Virology California Institute of Technology Pasadena, California, U.S.A. Dr. Carl M. EKLUND Rocky Mountain Laboratory National Institutes of Health Hamilton, Montana, U.S.A. Dr. Paul M. ELLWOOD, Jr. Assistant Medical Director Sister Elizabeth Kenny Foundation Minneapolis, Minnesota, U.S.A. Dr. Juan A. EMBIL Director, Viral and Rickettsial Department Municipal Children's Hospital Havana, Cuba Dr. George M. ERICKSON Dade County Health Department Miami, Florida, U.S.A. Dr. Martin Eugene FLIPSE Chief, Section of Preventive Medicine and Public Health University of Miami School of Medicine Miami, Florida, U.S.A. Dr. Sven GARD Professor of Virus Research Karolinska Institute Stockholm, Sweden xii Dr. James H. S. GEAR Director, South African Institute for Medical Research Johannesburg, Union of South Africa Dr. Henry M. GELFAND Chief, Enterovirus Unit Communicable Disease Center U. S. Public Health Service Chamblee, Georgia, U.S.A. Dr. Natan GOLDBLUM Director, Virus Laboratory Ministry of Health Tel Aviv-Yaffo, Israel Dr. Eduardo C. GUEVARA Ministry of Public Health San José, Costa Rica Dr. William McD. HAMMON Head, Department of Epidemiology and Microbiology Graduate School of Public Health University of Pittsburgh Pittsburgh, Pennsylvania, U.S.A. Dr. Albert V. HARDY Assistant State Health Officer Florida State Board of Health Florida State Department of Health Jacksonville, Florida, U.S.A. Dr. Herman E. HILLEBOE Commissioner of Health New York State Department of Health Albany, New York, U.S.A. Dr. Maurice R. HILLEMAN Director, Merck Institute for Therapeutic Research Merck and Company, Inc. West Point, Pennsylvania, U.S.A. Dr. Horace L. HODES Pediatrician-in-Chief The Mount Sinai Hospital New York, New York, U.S.A. Dr. Dorothy M. HORSTMANN Associate Professor of Preventive Medicine and Pediatrics Yale University School of Medicine New Haven, Connecticut, U.S.A.
Dr. George A. JERVIS Director of Research Letchworth Hospital New York State Department of Mental Hygiene Thiells, New York, U.S.A. Dr. Anne C. KIMBALL Chief, Section of Special Laboratory Studies Minnesota State Department of Health Minneapolis, Minnesota, U.S.A. Dr. Ruth L. KIRSCHSTEIN Division of Biologics Standards National Institutes of Health Bethesda, Maryland, U.S.A. Dr. Masami KITAOKA Chief, Department of Viral and Rickettsial Diseases National Institute of Health Shinagawa-ku, Tokyo, Japan Dr. Herman KLEINMAN Chief, Section of Chronic Diseases Division of Disease Prevention and Control Minnesota State Department of Health Minneapolis, Minnesota, U.S.A. Dr. Hilary KOPROWSKI Director, The Wistar Institute Philadelphia, Pennsylvania, U.S.A. Dr. Saul KRUGMAN Professor of Pediatrics New York University School of Medicine New York, New York, U.S.A. Dr. Alexander D. LANGMUIR Chief, Epidemiology Branch Communicable Disease Center U.S. Public Health Service Atlanta, Georgia, U.S.A. Dr. André J. G. LEBRUN Director, Marcel Wanson Institute of Hygiene Leopoldville, Belgian Congo Dr. Pierre R. LÉPINE Chief, Virus Research Division Pasteur Institute Paris, France xiii Dr. John O. MacFARLANE Assistant Director, Biological Development Eli Lilly and Company Indianapolis, Indiana, U.S.A. Dr. Joseph L. MELNICK Professor of Virology and Epidemiology Baylor University College of Medicine Houston, Texas, U.S.A. Dr. Malcolm H. MERRILL Director, California State Department of Health Berkeley, California, U.S.A. Dr. Arden W. MOYER Head, Virus Biological Research Department Lederle Laboratories American Cyanamid Company Pearl River, New York, U.S.A. Dr. Roderick MURRAY Director, Division of Biologics Standards National Institutes of Health Bethesda, Maryland, U.S.A. Dr. Frederick P. NAGLER Chief, Virus Laboratories Department of National Health and Welfare Ottawa, Ontario, Canada Dr. Nils C. OKER-BLOM Professor of Virology University of Helsinki Helsinki, Finland Dr. Joseph S. PAGANO Research Associate The Wistar Institute Philadelphia, Pennsylvania, U.S.A. Dr. John R. PAUL Professor of Preventive Medicine Yale University School of Medicine New Haven, Connecticut, U.S.A. Dr. Frank T. PERKINS Biological Standards Control Laboratory Medical Research Council Holly Hill, Hampstead London, England
Page 1 and 2: LIVE POLIO IRUS VACCINES Papers Pre
Page 3 and 4: SECOND INTERNATIONAL CONFERENCE ON
Page 5: Preface The accumulation of informa
Page 8 and 9: Page Discussion .......... .......
Page 10 and 11: Page 6. Vaccination of Full-Term In
Page 12 and 13: Page 23. Vaccination against Poliom
Page 16 and 17: Dr. Edith PETTE Institute for the R
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Page 21 and 22: 4 Introductory Remarks 4 Introducto
Page 23 and 24: 6 General Considerations immunity a
Page 25 and 26: 8 General Considerations from accep
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Page 31 and 32: 14 Safety-Laboratory Evidence of At
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Page 49 and 50: 32 TABLE 1. Safety-Laboratory Evide
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48 Discussion + - + + I + - I + + 1
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50 Discussion sages of neurovirulen
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Application of Genetic Markers to D
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Discussion 67 TABLE 1. INCIDENCE OF
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Experimental Studies on Animals wit
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6. DETECTION OF A "NON-DETECTABLE"
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Detection of a "Non-Detectable" Sim
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Discussion 87 Dr. Koprowski's state
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Discussion 89 recognize its effects
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Laboratory Investigations of Attenu
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Discussion 99 In the case of Table
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8. BEHAVIOR OF COLD MUTANTS OF POLI
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Behavior of Cold Mutants of Poliovi
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DISCUSSION CHAIRMAN BURNET: Thank y
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114 Safety-Field Evidence of Safety
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118 S afety-Field Evidence of S af
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122 Discussion 122 Discussion~~~~~~
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10. LABORATORY INVESTIGATIONS OF TH
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126 VIRUS 1 MAhONEY Safety-Field Ev
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128 Safety-Field Evidence óf Safet
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DISCUSSION CHAIRMAN ZHDANOV: This p
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11. EPIDEMIOLOGICAL AND VIROLOGICAL
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12. SPREAD OF A VACCINE STRAIN OF P
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148 Saf ety-Field Evidence of Saf e
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152 Saf ety-Field Evidence of Safet
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DISCUSSION CHAIRMAN ZHDANOV: The pa
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158 Discussion 158 Díscussion~~~~~
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160 Discussion specimens. We were u
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. . . 168 Safety-Field Evidence of
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14. THE CAPACITY OF LIVE ATTENUATED
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176 Saf ety-Field Evidence of Saf e
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Field, Laboratory Experiences With
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16. STUDIES ON LIVE POLIOVIRUS VACC
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Studies on Live Poliovirus Vaccine
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Da. HORSTMANN: If I may answer for
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Discussion 205 Discussion 205 tried
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NOTE: The Spanish translation of th
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Vaccination of Pregnant Women and Y
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Development and Persistence of Poli
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Virologic, Serologic Investigations
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_ _ _ _ _ _ _ _ Virologic, Serologi
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cARE NUC:4I Discussion 267 CUAw # J
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Discussion 269 in the investigation
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Virological Findings, Antibody Resp
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4. ROUTINE IMMUNIZATION WITH ATTENU
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Routine Immunization With Attenuate
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Experimental Infectionwith CHATAtte
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Experimental Infection with CHATAtt
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Experimental Infection with CHATAtt
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Vaccination of Full-Term Infants wi
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Response of Newborn Infants to Vacc
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Susceptibility of Newborn Infants t
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9. IMMUNIZATION OF NEWBORN INFANTS
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Immunization of Newborn Infants wit
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Discussion 323 vaccinated siblings
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Discussion 325 Discussion 325 ance
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transplacental antibodies, or antib
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Discussion 329 Discussion 329 born
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Recent Experience with Lederle Triv
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11. FURTHER EXPERIENCES WITH ORAL P
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Further Experiences with Oral Polio
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Minnesota Studies with Oral Poliomy
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13. USE OF ATTENUATED LIVE POLIOVIR
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Use of Attenuated Live Poliovirus V
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Use of Attenuated Live Poliovirus V
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DISCUSSION CHAIRMAN LÉPINE: The tw
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Discussion 373 -~~~~~~ics o 7 domin
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Discussion 375 -~ ~~~~isuso 7 DR. C
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i 14. EFFECTS OF RAPID MASS IMMUNIZ
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Live Poliovirus Immunization-Condit
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Use of Sabin's Live Poliovirus Vacc
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- Use of Sabin's Live Poliovirus Va
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TABLE 14. Use of Sabin's Live Polio
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Discussion 411 DR. ANDERSON: My que
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Course of Mass Immunization in USSR
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, _ _ Course of Mass Immunization i
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DISCUSSION CHAIRMAN LÉPINE: Thank
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Discussion 431 DR. STUART-HARRIS: I
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436 Efficacy-Field Evidence TABLE 1
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438 Efficacy-Field Evidence Adminis
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444 Effcaey-Field Evidence 44 Efiay
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446 Efficacy-Field Evidence 446 Eff
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448 Efficacy-Field Evidence 448 lEf
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450 Efficacy-Field Evidence m Co 0
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452 Efficacy-Field Evidence ] ~~ ~
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454 Efficacy-Field Evidence It is n
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456 Efficacy-Field Evidence M.G. C
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460 460 Discussion Discussion~~~~~~
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462 Discussion one was sponsored by
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Vaccination with CHAT Strain Type 1
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Live Virus Vaccine Studies in South
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Discussion 481 the ages of the five
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Immunological and Epidemiological E
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DISCUSSION CHAIRMAN STUART-HARRIS:
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Further Observations on First Field
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Further Observations Qn First Field
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Further Observations on First FielJ
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Poliomyelitis Vaccination in Poland
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24. A SMALL-SCALE TRIAL WITH LIVE P
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Live Poliomyelitis Vaccine-Small-Sc
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25. VACCINATION AND CHALLENGE-POLIO
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Vaccination and Challenge-Poliomyel
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26. VACCINATION WITH ATTENUATED POL
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Vaccination with Attenuated Poliovi
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Discussion 575 ence last year. The
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Large-Scale Practical Trials, Use o
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594 Discussion 594 Disenísion ~ ~
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596 Discussion 596 Díscussion~~~~~
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598 Discussion 598 Discussion high
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iiiii iirrrimrmiriiiilllniririiiiii
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602 Summary of the Conference 602 S
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Appendix The following letter was r
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608 Index Antibodies-continued half
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610 Index Bulychev, N. P., paper, 4
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612 Index Coxsackie--continued B-3
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614 Index Epidemics-continued intro
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616 Index Genetic stability-continu
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618 Index Infants-continued source
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620 Index Laboratory surveillance d
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622 Index Monkey neurovirulence, 95
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624 Index pH neutralization test, 6
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626 Index Poliomyelitis virus-conti
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628 Index Serological response-cont
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630 Index T marker-continued T- str
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632 Index Vaccine, Attenuated-conti
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634 Index Virus isolations and anti
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LIVE POLIO IRUS VACCINES

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