LIVE POLIO IRUS VACCINES

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Index 615 Field trials-continued Leopoldville, Congo, 466-473 Louisiana, 144-155 Managua, during epidemic, 547 Mauritius, 1959, 475-477 Mexico, 386-409 Miami, Florida, 435-444; 445-456 Minnesota, 161-173, 341-354, 357-364 Netherlands, 134-142 New England, 332 New Orleans, 308-314 Nicaragua, 547-560 Philadelphia, 277-283 Poland, 522-531 Rodrigues Island, 477-478 Santo Domingo de Heredia, Costa Rica, 113-120 Sottunga Island, Finland, 533-546 Sweden, 187-190 Switzerland, 322 Toluca, Mexico, 377-385 USSR, 240-265, 413-428, 576-587 United States and Latin America, 330-340 challenge, outbreak one year after oral vaccination, 559 clinical and virological surveillance, 594 epidemiological justification, 507 first step in offensive against polio, 578 incidence following, 429-430, 602 problems, listed, 576 public health policy basis, 3 reported by 24 groups from 13 countries, 601 safety and, 29 scientific principles, 3 vaccine competition with wild viruses, 29 Filter antibody test purified radioactive (P¿2) poliovirus, new method, 41, 266 Finland field trial (Sottunga), 533-546 isolated island community, 144 Fleer, G. P., paper 413-428; 416 Flies, polio isolated from, 34 Flipse, M. Eugene, paper 435-444, 445-456; 121, 124, 458, 459, 461, 463, 464 Floculation test, Mahoney eluate, 43 Florida Medical Association Polio Advisory Committee, 436 Florida State Board of Health, 436, 448 antibody determinations, 439 Foamy virus, see also Simian viruses, 86 chief troublemaker with British manufacturers. 88 contaminating agents, 80 demonstrated in 100% of vaccine from Sabin's strains, 86 destroyed by chloroform and ether, 87 Food and Drug Administration, U.S.A. tests for presence of viral agents, 8 Food handlers assigned placebo to obviate spread, 357 Ford, Marshall, 97, 131 Foundling hospital sanitary conditions and cold mutant stiiudy, New York, 107 Fox, see Poliomyelitis virus, Type 3, Fox Fox, John P., paper 144-155; 308-314; 6-7, 24, 58, 143, 156, 597 Franklin, Benjamin, glass houses dictum, 7 Franklin, Louisiana heavily seeded community, 148 homogeneous play community, 145 map, 146 French inactivated vaccine Beta-propiolactone inactivated, 532 pattern of elution of strain 1342, 44 Friedman, Robert M., paper, 89-96, 124-131 Fukuoka, Japan immune response and virus isolations of vaccinees, 198 Fukuoka University, 193 Galilee Kyriat Shmone, newly developed settlement, immigrants, 270 Gallocyanin method, monkey sections, 31 Gamma-globulin after inoculation with live vaccine, 526 and virulent polio in monkeys, 324-325 antibody titer and concentration of virus, 100 blocking effects of IM inoculation, 94, 98 effect on neurovirulence, 95 first produced at about six weeks of age, 224, 300 21 half-day life, 294 "Gang-caged" Indian monkeys not in single cages, 84 García, M. Roca-, see Roca-García, M. Gard, Sven, paper 187-190; 7, 53, 144, 202, 206, 229, 267, 268, 532, 593, 596, 597 Gard immunoinactivation test method, 230 Gastrointestinal tract cold mutant study, 107 in spread study, 169 pH determined of newborns, 306 physiological change in infants and polio resistance, 299 resistance interferes with vaccination, 121 tissue culture characteristics before and after passage, 124-131 Gavage CHAT Type 1 on third day of life, 287 Gdansk, Poland virus isolations, 531 Gear, James H. S., paper 474-479; 86-88, 121, 157, 202, 206, 266, 326, 327, 465, 480, 505 Gelatin capsules, 342, 357 Gelfand, Henry M., paper 144-155, 308-314; 6-7, 24, 58, 143, 156, 158-159, 172, 238, 294, 320, 325, 336, 371, 439 Gelfand, Salk vaccine study, 339 Genetic characteristics hypothesis of many genes, and markers, 47 Genetic markers, see Markers Genetic stability caution in interpretation due to mutants, 480 changing concept, 45 demonstrated by MS markers, 197 influenced by combination of types, 574
616 Index Genetic stability-continued of polio not stable, 110 of Sabin strains, 414 Type 3 less than Types 1 and 2, 141 vaccine requirement, 192 Georgetown University School of Medicine, 4 Georgiades, Dr. -, 531 Georgian SSR two vaccinations, 1960, 419, 582 German Democratic Republic, 422, 587 Gervais, Luis, paper, 365-370 Ghyssels, Dr. -, 473 Giardia lamblia, atebrine treatment, 368 Giebenhain, Margaret, 226 "Glenn," see Poliomyelitis virus, Type 3, "Glenn" Goldblum, Natan, paper 270-276; 269, 325 Goldschneider, Toby, 292 Gómez, H. Abad, see Abad Gómez, Héctor Good, R., 224 Gottwaldov region, Czechoslovakia, polio incidence, 518 "Graded clharacteristic," markers, 109 Granada, Nicaragua, epidemic, 1959-60, 547 Gray, Nigel, paper, 302-307 Green, R. H., paper 174-184 Green monkeys (Cercopithecus aethiops), see also Grivet, Vervet, African green monkey 20 subspecies or races, described, 87-88 Greenberg, Morris, 321 Greenland Type 3 epidemic, 122 Grivets confusion with vervets, 87 northeast African green monkeys, 88 Groisman, G. M., paper, 482-501 Grove East, Minnesota operating plan of study, 343 Growth curve more sensitive temperature marker test, described, 64 of vaccine and isolates, 60 Growth requirement and covariation, 49 strains, study needed, 190 Grumbach, Dr. -, 328 Guadalajara, Mexico epidemic and vaccination program, 396 vaccination program, 1958, 386 Guanacaste province, Costa Rica vaccination program, 1960, 563 Guatemala, serological studies, 574 Guevara, E. C., paper, 561-573 Guinea pigs intratypic serodifferentiation test, 53 spillover experiment, 100 vaccine test, 505 Gyorgi, Paul, 292 H 24, see Poliomyelitis virus, Type 3, H 24 H marker a strain marker, 188 related to T and d marker, 188-189 ___ Habel, Karl, 80 Hammon, William McDowell, 203, 205 Hanks' solution, 162, 241, 271, 309, 310 in t marker test, 138 Hanoi, North Viet Nam epidemic of about 1,000 cases, Type 2, 595 1.5 million children vaccinated, 419 Hardy, A. V., paper 435-444, 445-456; 463 Harmlessness, see Safety Harwin, R., 79, 83, 86 Havana Municipal Children's Hospital, 368 Heel puncture, blood specimens, 288 Heidenhain, staining technique, 69 HeLa cells, 80, 287, 359, 363 in vaccine preparation, 599 virus isolations, 162, 536 Helsinki University, Department of Virology, 536 Hematoxylin-eosin for histological examination of brain and cord, 69 Henningsen, Donna, 226 Hep.-2 cells, 114 in enteric virus search, 123 Heredia province, Costa Rica vaccination program, 1960, 563 Hernández Miyares, Carlos, paper, 365-370 Herpangina and polio vaccination, 368 Hiatt, Dr.- 87 Hilleboe, Herman E., 322, 324, 328, 329 Hilleman, Maurice R., paper 79-85; 67, 86-88, 132 Hin, Chung, see Chung Hin Histologic examination alterations corresponded to polio, 69 comparison of vaccines, 13 contrast, vaccine and virulent polioviruses, 32 lesions and paralytic rates essentially the same, 77, 94 of brain and cord after 21 days, 536 technique, 31 Hodes, Horace L., paper 41-43; 44-45, 49, 266 Hodgkins disease and polio risk, 461 Hoffert, W. R., paper 435-444 Holguin, Alfonso H., paper 308-314 Holland, John J., 62 Holmes, Sherlock inverse deduction allusion, 9 Horstmann, Dorothy M., paper 113-120, 174-184; 6-7, 121-123, 132, 139, 156, 158, 174, 203, 205 Horwitz, Abraham, 3-4, 605 Host cell range cytopathic effect of vacuolating agent, 84 Hottle, George, paper 90-97, 124-131 Houston, see Poliomyelitis virus, Type 1, Houston Houston, Texas strains isolated from vaccinees, 23-24 Howe, H. A., 95, 205 Howell, F., Jr., paper 435-444 Hsiung, C. D., 34 Huebner, R., 80 Huenekens, E. J., 605 Hughes, Dorothy S., 97, 131 lHull, R. N., 79, 83, 85 Human embryonic kidney, plaque-forming capacity, 188
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LIVE POLIO IRUS VACCINES Papers Pre
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SECOND INTERNATIONAL CONFERENCE ON
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Preface The accumulation of informa
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Page 6. Vaccination of Full-Term In
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Page 23. Vaccination against Poliom
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Dr. Ghislain COURTOIS Director, Pri
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Dr. Edith PETTE Institute for the R
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4 Introductory Remarks 4 Introducto
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6 General Considerations immunity a
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8 General Considerations from accep
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10 General Considerations 10 Genera
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14 Safety-Laboratory Evidence of At
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- 26 Safety-Laboratory Evidence of
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DISCUSSION CHAIRMAN ANDERSON: There
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30 Discussion CHAIRMAN ANDERSON: Th
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32 TABLE 1. Safety-Laboratory Evide
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40 Discussion Of the 22 monkeys inf
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DISCUSSION CHAIRMAN ANDERSON: Thank
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46 Discussion a paralytic case. Thi
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48 Discussion + - + + I + - I + + 1
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50 Discussion sages of neurovirulen
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Application of Genetic Markers to D
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Discussion 67 TABLE 1. INCIDENCE OF
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Experimental Studies on Animals wit
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6. DETECTION OF A "NON-DETECTABLE"
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Detection of a "Non-Detectable" Sim
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Discussion 87 Dr. Koprowski's state
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Discussion 89 recognize its effects
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Laboratory Investigations of Attenu
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Discussion 99 In the case of Table
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8. BEHAVIOR OF COLD MUTANTS OF POLI
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Behavior of Cold Mutants of Poliovi
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DISCUSSION CHAIRMAN BURNET: Thank y
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114 Safety-Field Evidence of Safety
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118 S afety-Field Evidence of S af
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122 Discussion 122 Discussion~~~~~~
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10. LABORATORY INVESTIGATIONS OF TH
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126 VIRUS 1 MAhONEY Safety-Field Ev
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128 Safety-Field Evidence óf Safet
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DISCUSSION CHAIRMAN ZHDANOV: This p
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11. EPIDEMIOLOGICAL AND VIROLOGICAL
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12. SPREAD OF A VACCINE STRAIN OF P
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148 Saf ety-Field Evidence of Saf e
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152 Saf ety-Field Evidence of Safet
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DISCUSSION CHAIRMAN ZHDANOV: The pa
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158 Discussion 158 Díscussion~~~~~
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160 Discussion specimens. We were u
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. . . 168 Safety-Field Evidence of
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14. THE CAPACITY OF LIVE ATTENUATED
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176 Saf ety-Field Evidence of Saf e
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Field, Laboratory Experiences With
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16. STUDIES ON LIVE POLIOVIRUS VACC
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Studies on Live Poliovirus Vaccine
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Da. HORSTMANN: If I may answer for
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Discussion 205 Discussion 205 tried
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NOTE: The Spanish translation of th
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Vaccination of Pregnant Women and Y
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Development and Persistence of Poli
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Virologic, Serologic Investigations
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_ _ _ _ _ _ _ _ Virologic, Serologi
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cARE NUC:4I Discussion 267 CUAw # J
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Discussion 269 in the investigation
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Virological Findings, Antibody Resp
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4. ROUTINE IMMUNIZATION WITH ATTENU
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Routine Immunization With Attenuate
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Experimental Infectionwith CHATAtte
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Experimental Infection with CHATAtt
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Experimental Infection with CHATAtt
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Vaccination of Full-Term Infants wi
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Response of Newborn Infants to Vacc
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Susceptibility of Newborn Infants t
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9. IMMUNIZATION OF NEWBORN INFANTS
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Immunization of Newborn Infants wit
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Discussion 323 vaccinated siblings
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Discussion 325 Discussion 325 ance
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transplacental antibodies, or antib
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Discussion 329 Discussion 329 born
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Recent Experience with Lederle Triv
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11. FURTHER EXPERIENCES WITH ORAL P
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Further Experiences with Oral Polio
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Minnesota Studies with Oral Poliomy
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13. USE OF ATTENUATED LIVE POLIOVIR
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Use of Attenuated Live Poliovirus V
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Use of Attenuated Live Poliovirus V
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DISCUSSION CHAIRMAN LÉPINE: The tw
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Discussion 373 -~~~~~~ics o 7 domin
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Discussion 375 -~ ~~~~isuso 7 DR. C
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i 14. EFFECTS OF RAPID MASS IMMUNIZ
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Live Poliovirus Immunization-Condit
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Use of Sabin's Live Poliovirus Vacc
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- Use of Sabin's Live Poliovirus Va
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TABLE 14. Use of Sabin's Live Polio
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Discussion 411 DR. ANDERSON: My que
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Course of Mass Immunization in USSR
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, _ _ Course of Mass Immunization i
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DISCUSSION CHAIRMAN LÉPINE: Thank
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Discussion 431 DR. STUART-HARRIS: I
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436 Efficacy-Field Evidence TABLE 1
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438 Efficacy-Field Evidence Adminis
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444 Effcaey-Field Evidence 44 Efiay
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446 Efficacy-Field Evidence 446 Eff
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448 Efficacy-Field Evidence 448 lEf
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450 Efficacy-Field Evidence m Co 0
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452 Efficacy-Field Evidence ] ~~ ~
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454 Efficacy-Field Evidence It is n
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456 Efficacy-Field Evidence M.G. C
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460 460 Discussion Discussion~~~~~~
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462 Discussion one was sponsored by
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Vaccination with CHAT Strain Type 1
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Live Virus Vaccine Studies in South
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Discussion 481 the ages of the five
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DISCUSSION CHAIRMAN STUART-HARRIS:
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Further Observations on First Field
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Further Observations Qn First Field
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Further Observations on First FielJ
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Poliomyelitis Vaccination in Poland
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24. A SMALL-SCALE TRIAL WITH LIVE P
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Live Poliomyelitis Vaccine-Small-Sc
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25. VACCINATION AND CHALLENGE-POLIO
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Vaccination and Challenge-Poliomyel
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26. VACCINATION WITH ATTENUATED POL
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Vaccination with Attenuated Poliovi
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Page 619 and 620: 602 Summary of the Conference 602 S
Page 622: Appendix The following letter was r
Page 625 and 626: 608 Index Antibodies-continued half
Page 627 and 628: 610 Index Bulychev, N. P., paper, 4
Page 629 and 630: 612 Index Coxsackie--continued B-3
Page 631: 614 Index Epidemics-continued intro
Page 635 and 636: 618 Index Infants-continued source
Page 637 and 638: 620 Index Laboratory surveillance d
Page 639 and 640: 622 Index Monkey neurovirulence, 95
Page 641 and 642: 624 Index pH neutralization test, 6
Page 643 and 644: 626 Index Poliomyelitis virus-conti
Page 645 and 646: 628 Index Serological response-cont
Page 647 and 648: 630 Index T marker-continued T- str
Page 649 and 650: 632 Index Vaccine, Attenuated-conti
Page 651: 634 Index Virus isolations and anti
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