LIVE POLIO IRUS VACCINES

Further Experiences with Oral Poliomyelitis Vaccines in Minnesota
345
clinics, distributed stool specimen containers, and
either fed or supervised the feeding of the liquid
vaccine or placebo as the case might have been.
These activities alone brought them into frequent
contact with the participating families. In addition,
they were subject to call for consultation on
any problem that a family wished to discuss
with them. Participants were encouraged to report
illnesses or symptoms to the public health
nurses.
Liaison was established with the physicians
who ordinarily treated these people and who
might therefore be consulted for something that
occurred during the course of the study. Two
physician members of the project team (W.E.M.
and H.K.) were also available for consultation.
The above arrangements insured, so far as was
possible, that the medical and nursing surveillance
would be complete and continuous. The
entire project was operated from an office close
to the village site, especially rented for this
purpose. The project's office telephone was connected
in with the switchboard serving the Minnesota
Department of Health.
EVALUATION OF SYMPTOMS OCCURRING
DURING CONTROL PERIOD
The symptoms which occurred during the control
period are set out week by week in Table 3.
These data, of course, were recorded without
knowing whether the complainant had received
vaccine virus or placebo. It appears evident from
the meager entries in the table, that for the most
part, both adults and children remained well
through the control period.
The respiratory symptoms in both adults and
children appear to be concentrated in time suggesting
that these individuals had picked up
something that was "going around". Indeed,
several of the entries represent multiple cases in
one family. Of the five diarrheas recorded in the
virus-fed during the week beginning March 29,
four occurred in one family. The symptoms in
this family did not occur soon after a feeding.
Actually, the second feeding date had to be postponed
for these individuals until the bowel
disturbances had subsided. Certain of the communicable
diseases, scarlet fever and chickenpox,
did appear but not until the control period
TABLE 4A. ANTIBODY RESPONSES TO MONOVALENT ORAL POLIOMYELITIS VACCINE, GROVE EAST, 1959
CHILDREN
TYPE 1
TYPE 2
TYPE 3
No.
OF
SALK
DOSES
INITIAL TITER
No
Change
Booster
INITIAL TITER
No
Change
Booster
INITIAL TITER
No
Change
Booster
0
O
3
0
1
2
2
o
o
o
1
o
3
1
O
0
O
0
O
0
0
o
o
O
o
o
2
O
15
0
1
O
11
1
4
0
16
o
o
3
O
20
4
7
O
6
7
18
1
16
7
7
4
O
3
3
3
O
1
3
5
0
4
2
3
Totals
O
41
7
12
2
20
11
27
1
37
9
13