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ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

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emoved the oscillations partially and is indeed more representative of the true<br />

configuration of the transition between the two IVD sub-tissues.<br />

The results suggest that most of the existing spine poromechanical models are not<br />

suitable to locally simulate the effect of physiological loading rates. Nonetheless,<br />

provided that mesh convergence has been properly assessed through poromechanical<br />

predictions, 30 minutes of load relaxation could be sufficient for these instabilities to<br />

disappear. This time frame is inferior to that found in the previous studies using<br />

poroelastic models mechanically loaded for more than one hour (Schroeder et al., 2007<br />

Malandrino et al., 2011).<br />

6. ACKNOWLEDGMENTS<br />

Financial funding from the European Commission (MySpine FP7-ICT-269909) is<br />

acknowledged.<br />

7. REFERENCES<br />

1. Roberts, S., Evans, H., Trivedi, J. & Menage, J., Histology and pathology of the<br />

human intervertebral disc. J Bone Joint Surg Am., 2006, Vol. 88 Suppl 2:10-4.<br />

2. Laible, J.P., Pflaster, D.S., Krag, M.H., Simon, B.R. & Haugh, L.D., A poroelastic -<br />

swelling finite- element model with application to the intervertebral disc. Spine,<br />

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3. Ferguson, S.J., Ito, K., & Nolte, L.P., Fluid flow and convective transport of solutes<br />

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unconfined compression implicates mechanoregulation by fluid shear stress. Ann.<br />

Biomed. Eng., 2010, Vol. 39, 1101–1111.<br />

5. Malandrino, A., Noailly, J. & Lacroix, D., The Effect of Sustained Compression on<br />

Oxygen Metabolic Transport in the Intervertebral Disc Decreases with Degenerative<br />

Changes. PLoS Comput Biol., 2011, Vol. 7(8)<br />

6. Stokes, I., Chegini, G., Ferguson, S., Gardner-Morse, M., Iatridis, J. & Laible, J.,<br />

Limitation of Finite Element Analysis of Poroelastic Behavior of Biological Tissues<br />

Undergoing Rapid Loading. Ann. Biomed. Eng., 2010, Vol. 38, 1780-1788.<br />

7. Argoubi, M. & Shirazi-Adl, A., Poroelastic creep response analysis of a lumbar<br />

motion segment in compression. J. Biomech., 1996, Vol. 29, 1331–1339.<br />

8. Noailly, J., Wilke, HJ., Planell, JA. & Lacroix, D., How does the geometry affect<br />

the internal biomechanics of a lumbar spine bi-segment finite element model?<br />

Consequences on the validation process, J. Biomech., 2007, Vol. 40, 2414-2425.<br />

9. Schroeder, Y., Sivan, S., Wilson, W., Merkher, Y., Huyghe, JM., Maroudas, A. &<br />

Baaijens, FP., Are disc pressure, stress, and osmolarity affected by intra- and<br />

extrafibrillar fluid exchange?. J Orthop Res., 2007, Vol. 25, 1317-24.

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