ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

the efficacy of predicting cellular response from a homogenous macro-level (e.g.
cartilage) model, where predictions of average response may not require direct coupling
of the scales [14]. While it appears this finding is influenced by cell density and tissue
complexity, it is also recognized that homogeneous constitutive models, representative
of underlying cell distribution and mechanics, may also be feasible [15]. From a
functional and clinical perspective, implications include, among others, development of
an evaluation tool able to address mechanobiological aspects of osteoarthritis
development and treatment, all within the context of body level loading.
Acknowledgments: support from grant R01EB009643 provided by the National
Institute of Biomedical Imaging and Bio-engineering, National Institutes of Health, is
greatly appreciated. This research was also supported in part by the National Science
Foundation through XSEDE provided by the XSEDE Science Gateways program.
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