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INVESTIGATING CHANGES IN JOINT LOADING FOLLOWING HIGH TIBIAL OSTEOTOMY 1. ABSTRACT G.M. Whatling 1 , D. Watling 2 , C Wilson 3 and C.A. Holt 4 High tibial osteotomy (HTO) surgery is performed as a treatment for medial compartment knee osteoarthritis (OA), where the joint is realigned to redistribute loading and relieve pain. Changes in joint alignment intend to shift the location of force transmission and the mechanical stresses from the diseased medial to the healthy lateral knee compartment. The aim of this study is to identify the efficacy of HTO surgery in modifying knee loading. Peak external knee adduction moment (EKAM) and knee adduction angular impulse (KAAI) provide useful information on medial compartment loading and disease severity. In this study, KAM and KAAI measured during level gait were investigated from 10 patients pre HTO surgery and 6 patients post HTO surgery using three-dimensional motion analysis and biomechanical modeling using Visual3D (C-motion. Inc). Two patient reported outcomes (The Knee Outcome Survey and Oxford Knee Scores) were also completed by each patient. A statistically significant reduction in EKAM, KAAI was calculated post-HTO surgery, indicating decreased load through the medial knee compartment. There was also a statistically significant increase in the two patient scores indicating improved patient perceived function. A decrease in EKAM and KAAI for the contra-lateral non affected limb was identified, though this was not statistically significant. 2. INTRODUCTION Osteoarthritis (OA) affects 8 million people in the UK [1]. It is a degenerative joint disease most prevalent in the medial compartment, where articular cartilage deteriorates, causing joint stiffness and pain. Increasing evidence supports the hypothesis that joint degeneration is driven by biomechanical forces and the pathological response by the surrounding tissues [2]. The knee joint bears up to 2.5 times body weight during level gait [3]. The ground reaction force (GRF) passes medially to the joint centre, resulting in the medial compartment experiencing the greatest proportion of the load [4,5]. Thus, knee OA predominantly affects the medial compartment leading to loss of cartilage, change in the subchondral bone, a reduction in joint space and consequently a varus deformity [6]. Varus deformity results in increased loads in the medial compartment. Thus patients with varus knee alignment are prone to developing more severe medial compartment OA unless the mechanics are corrected [7,8]. 1 Academic Fellow, School of Engineering, Cardiff University, CF243AA, Wales, UK 2 PhD Student, School of Engineering, Cardiff University, CF243AA, Wales, UK 3 Consultant Orthopaedic Surgeon, University Hospital of Wales, Cardiff 4 Reader, School of Engineering, Cardiff University, CF24 3AA, Wales, UK 1-4 Arthritis Research UK Biomechanics and Bioengineering Centre, Cardiff University, Wales, UK
High tibial osteotomy (HTO) surgery (Fig 1.) is a treatment option for medial compartment knee osteoarthritis (OA). The joint is realigned to correct varus malalignment and relieve pain. This is achieved through the lateral removal or medial addition of a wedge of bone in the proximal tibia, followed by rigid fixation. The ‘opening wedge’ procedure is becoming more commonly employed [9] and is used for subjects in this study. This involves a cut across the proximal tibia, which is opened up, filled with calcium phosphate or bone graft and rigidly fixed with a plate [10]. The gap subsequently fills with bone. The change in joint alignment intends to shift the location of force transmission and the mechanical stresses from the diseased medial to the healthy lateral knee compartment. It delays the need for a joint replacement, making it a favorable treatment option for younger and active patients. Studies investigating the relationship between dynamic gait measurements and longterm clinical outcome have identified peak external knee adduction moment (EKAM) as an important clinical marker [8, 11-13] of medial compartment loading and OA severity [14], where an increase in EKAM indicates an increase in medial compartment loads. It has been identified as a predictor of the ratio of medial-to-lateral proximal tibial bone mineral content and load distribution on the tibial plateau. Studies using two and threedimensional models have found correlations between KAM and internal kinetic changes [15,16]. Therefore it can be used to quantify the benefits of HTO. Increased external EKAMs is indicative of increased loads in the medial compartment relative to the lateral compartment. Peak adduction moment for subjects with no pathology ranges between 2.5 to 4.75 (% Body weight (BW) x height (h)). Patients with OA have been reported to have a higher 1 st peak EKAM than subjects with no pathology. Those with severe OA with a KL score greater than 3 also have a higher 2 nd peak EKAM [17]. Patients with below-average KAMs post-surgery (less than about 2.5 %BW x h) were found to have better long-term clinical outcome [11], regardless of their pre-surgery moment. Birmingham [18] have shown that the largest change in EKAM moment occurs at 6 months post op, with only a small increase (13%) observed from 6 to 24months. Thus patient assessments between 6-9 months post-op were selected for investigation in this study. 3. METHODS Bi-lateral knee function during gait was evaluated for 10 subject’s pre-HTO surgery (height: 1.71±0.11m, mass: 85.9±15.9Kg). 6 subjects were re-assessed between 6 to 9 months following unilateral HTO using the opening wedge approach. Ethical approval was granted by the Research Ethics Committee for Wales and Cardiff and Vale University Health Board. 49 light retro-reflective markers were positioned in a modified Cleveland clinic marker set [19] and 3D motion capture (Qualisys, Sweden and Bertec Corporation) used to record 6 trials of level gait at self-selected speeds. Biomechanical models of each subject were created in Visual3D (C-motion, Inc) to compute temporal, kinematic and kinetic data. Each subject completed the Knee Outcome Survey (KOS) [20] and Oxford Knee Score (OKS) [21] at the start of each data collection. One way ANOVA was performed to identify changes in EKAM and KAAI (for the operative and non-operative leg), OKS and KOS following HTO surgery.
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The Proceedings of the 10 th Intern
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Install Adobe Reader 8 or 9 (http:/
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Content: POSTERS: BRAIN: CELL: EVAL
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Modeling of blood flow through a fl
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The mesh generation of the model wa
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Figure6 . The stroke volume data fo
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Digital Subtraction Phonocardiograp
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mobile cart for easy recording in c
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Figure 7. This image shows PCG samp
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Our approach is an improvement in t
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one cements as well as its behaviou
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Typical dimensions of lumbar verteb
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attributed to the change of stiffne
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lifestyle and obesity. In that cont
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T was the temperature in Kelvin and
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sustained tensile strains stimulate
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An approach aiming at determining a
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failure load. 2.4 Simulation of reh
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REFERENCES 1. Vunjak-Novakovic G, A
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3. FIF-BAL BIOREACTOR The FIF devic
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value of p nearest to dqc=0 we cont
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(Wanless, 1999). This low value cou
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3. MATERIALS AND METHODS A CAD mode
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did not allow gap closure. Maximum
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hand, if the IFM is too large, remo
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2. INTRODUCTION Intervertebral disc
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Figure 3. T1 signal enhancement in
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1. ABSTRACT TIP CELLS AT THE TOP: M
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Fig. 1. Schematic overview of the m
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Fig. 3. Image of the amount of VEGF
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THE COMPUTATIONAL MODEL OF DENTAL I
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processing application STL Model Cr
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For the implant/bone interaction as
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ABSTRACT THE IMPACT OF SELECTION BI
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Figure 1: flow chart showing the op
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Figure 2: Time course of cytosolic
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CONSTITUTIVE MODELLING OF THE ANNUL
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it is well known the non-linear nat
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Therefore, we have decided to carry
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EXTRACTION OF PHALANGEAL JOINT PARA
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column vectors of P. Denoting the v
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End i joint angles and length offse
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Validation of Strain Mapping for th
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allows the calculation of strain ma
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RMS error was 0.054 and the strains
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AN APPROACH FOR THE REDUCTION OF TH
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The relation between the time-deriv
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Error in position [mm] Error in pos
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ANALYSIS OF THE INTRAINDIVIDUAL DIF
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Fig.1: Frontal view on all subchond
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[6] M. Bozkurt, B. B. Kentel, G. Ya
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on the actual necessary time needed
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Illustration 2: The initially spher
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cell if it is hardly able to deform
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fit with a reference anatomy in min
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show that patellar mal-positioning
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Experimental and numerical analysis
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stenosis in both simulations and ex
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stented case, corresponding to the
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EVALUATION OF DIFFERENT LOADING CON
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were modeled with identical geometr
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each simulation and the position of
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FINITE ELEMENT MODEL ANALYSIS OF HU
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Figure 1: Maximal principal strains
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Method for classification of porcin
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3.3 Identification of Paths Accordi
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Table. 1. Descriptive Patterns used
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CHARACTERIZING THE MECHANICAL MICRO
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3.1.3 Cell proliferation It is assu
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Stress [Pa] 4 3 2 1 0 Mean stress A
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REFERENCES [1] A.M. Bratt-Leal, R.L
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y exposure to interstitial fluid sh
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according to (Eq. 2), nor averaged
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emoved the oscillations partially a
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static load and a dynamic load. A s
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positive effect of the number of ac
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pathways and their interactions tha
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applications, the need for accuracy
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avoid violating the initial geometr
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6. CONCLUSION The examples of appli
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Fig. 1 Semicircular canal structure
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4. RESULT Fig. 6 FSI model of semic
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6. ACKNOWLEDGEMENT This research wa
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ods to the biocompatible plastic po
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Table 1: Analysis conditions Static
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[3] Brantigan, J. W., Steffee, A. D
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femoral head fracture, the femoral
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Fig 3. Schematic drawing of the ste
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6. CONCLUSION Fig 7. Analysis resul
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and angular rates were registered b
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former, there were assumed the foll
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delivered dynamic support, which pr
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insertion of provisional restoratio
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Figure 4: Implant displacements obt
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5. DISCUSSION AND CONCLUSION Initia
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at which microdamage originates. Fo
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4. RESULTS The load response varied
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current study to explore the effect
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implant correctly from the finite e
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(a) (b) (c) (d) (e) Figure 3. The s
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(a) (b) Figure 6. The meshed model
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(a) (b) Figure 9. Cumulative probab
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NUMERICAL EVALUATION AND MEDICAL CO
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compared by overlaying the real dat
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four sample patient data, outcomes
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A POROELASTIC APPROACH FOR AN OPEN
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where indexes U, P refer to the unk
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RESULTS As a preliminary test, a 0.
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BIOMECHANICAL BEHAVIOR OF CANCELLOU
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cement acts perfectly, therefore it
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cancellous bone of natural joints a
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COMPUTATIONAL MODELING OF TANGLED A
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The centers of the simulated cells
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untangled, the local fiber displace
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TOWARDS A WAVELET BASED MEDICAL IMA
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however at each decomposition scale
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the MATLAB software (for the Modifi
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A FLUID STRUCTURE INTERACTION MODEL
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hyperelastic based on available exp
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t [ms] 30 70 160 220 270 Pressure [
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MECHANICAL BAHAVIOR OF DIFFERENT NI
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parameters necessaries to use this
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F1 and Mtwo were directly related t
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MECHANICAL EFFECT ON METABOLIC TRAN
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an initial nil lactate concentratio
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present study, such values were phe
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EVALUATION OF FEMORAL COMPONENT MIC
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TS implants employed a “hybrid”
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5. DISCUSSION i ii Figure 2: Compar
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THE MECHANICAL ENVIRONMENT IN THE D
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instead the femur was supported by
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It must be noted however, that in t
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1. ABSTRACT MODELING OF ARTICULAR C
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exp 1 1 2 1 where and are i
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Implant Fig.2. Axisymmetric represe
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A MULTI-SCALE ANISOTROPIC CONSTITUT
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3.2 Decoupled invariant formulation
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Fig. 1. Experimental data from unia
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VALIDATION AND CALIBRATION PROCESSE
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Figure 1: A three-step process simu
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The validation process employed on
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FLUID-STRUCTURE INTERACTION ANALYSI
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The coupled SQA model and the conve
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Point P7, located at the toe of the
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THE INFLUENCE OF UNCERTAIN ANATOMIC
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Figure 3 exemplifies for intradisca
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8. CONCLUSIONS Unsurprisingly, the
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COMPARISON OF DIFFERENT LOADING CON
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Figure 1 Finite element model of th
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6 CONCLUSION It is a feasible way t
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FROM CELL CONTRACTILITY TO CURVATUR
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4. MODEL When cells adhere on a sub
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organisation. Understanding the pri
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PREOPERATIVE PLANNING SUPPORT SYSTE
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[9]. Stenosis of 25, 45, 65 and 85
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Fig. 1:Dependent and independent va
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1. ABSTRACT Local strain measuremen
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around 100µm (halfway through the
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sampling points at different cross
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CLASSIFICATION OF PHYSICAL ACTIVITY
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induces a vertical alignment of the
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accelerations combination). However
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line under translation. Information
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In this study, we apply a meshless
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used the PAC constitutive constants
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1006031) is gratefully acknowledged
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improvements were seen in both grou
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Pre-augmentation Position 1, V=3mL
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5. ACKNOWLEDGEMENTS Funding for thi
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the hemodynamics in cerebral aneury
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4. RESULTS AND DISCUSSION In order
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processing methods need to be devel
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3. METHODS 3.1 Experimental Method
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Figure 2 - Micrographs for tensile
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analysis of the tissue mechanics. B
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3. METHODS 3.1 Specimen Preparation
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of five points across the mid mid-c
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equired to replicate the deformatio
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pre-load within the plate (compress
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4. RESULTS The load-deformation beh
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fracture fixation. Medical Engineer
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model. It approximates knee kinemat
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computational cost remains moderate
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Concerning the optimization procedu
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aesthetic recovery. However, in som
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atio experimented by both wounds is
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VARIATION OF MICRO-ARCHITECTURE AND
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osteoporotic (OP). The sample volum
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Figure 4: Mean error in orthotropy
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INVESTIGATION OF CORTICAL SHELL STR
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When creating the degenerated FE mo
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Figure 4. Degeneration sensitivity
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METHODS TO ACCELERATE FINITE ELEMEN
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the “joint” constraints configu
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Figure 4: Absolute prediction error
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EFFECT OF POST TREATMENT FOR MULTIP
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Fig.2 Inlet velocity profile indica
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4.3 WSS results Figure 8 shows the
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approximated by the so-called Ritz
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Page 402 and 403: There is no optimal density-elastic
Page 404 and 405: Fig. 2 Cut view of FE-model. Shown
Page 406 and 407: 5. Weis JA, Miga MI, Granero-Moltó
Page 408 and 409: 3. SYSTEM DESIGN Sheep eyes, as the
Page 410 and 411: which provides natural tactile feed
Page 412 and 413: 113:341-342 20. Henderson B. A., Gr
Page 414 and 415: health area. According to estimates
Page 416 and 417: Table 1. RMS Value based on subject
Page 418 and 419: 6. REFERENCES 1. http://www.disable
Page 420 and 421: ehavior [5]. From the viewpoint of
Page 422 and 423: Fig. 1 Average Male and Female's L4
Page 424 and 425: 4. Deyo, R.A., and Weinstein, J. N.
Page 426 and 427: geometry of the cell and ECM degrad
Page 428 and 429: Shown in Fig. 2(b) is a plot of the
Page 430 and 431: 6. REFERENCES 1. Dubin-Thaler B.J.,
Page 432 and 433: We implemented our individual-based
Page 434 and 435: 3.3.1 Centers of mass Table 1: Base
Page 436 and 437: average coordination num ber averag
Page 438 and 439: BIOMECHANICAL ANALYSIS OF THE MUSCU
Page 440 and 441: of the ligament strain; a linear re
Page 442 and 443: lengthening, respectively, if compa
Page 444 and 445: THE EFFECT OF HIGH TIBIAL OSTEOTOMY
Page 446 and 447: The 3D LiveWire tool was used as an
Page 448 and 449: Table II: Peak medial and lateral f
Page 452 and 453: 4. RESULTS Table 1 shows the mean m
Page 454 and 455: Fig.5 displays the OKS and KOS pre
Page 456 and 457: Dynamic Touch of Effective Golf Swi
Page 458 and 459: properties of a golf club and hand
Page 460 and 461: perturbation in e3 whereas player B
Page 462 and 463: 1. Kim, W., Response to letter to t
Page 464 and 465: configuration.[4] have explained ho
Page 466 and 467: compartments as well as a single mu
Page 468 and 469: 5. Shabana, A.A., Dynamics of multi
Page 470 and 471: Five healthy volunteers (age: 38.3
Page 472 and 473: internal lumbar spinal shape was de
Page 480 and 481: Airflow Simulation of Nasal Cavity
Page 482: temperature [5], and Wbl is the wat
Page 485 and 486: Figure 8. Figure 8(a) illustrates t
Page 487 and 488: Finite element models of the hip ca
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Page 491 and 492: 5. DISCUSSION Previous DEA implemen
Page 493 and 494: STATISTICAL SHAPE MODELING OF CAM-T
Page 495 and 496: Thirty-three control femurs (25 mal
Page 497 and 498: asymptomatic subjects 7,9 . The Hot
Page 499 and 500: 6. REFERENCES 1. Ganz, R., Parvizi,
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NUMERICAL IDENTIFICATION OF THE PER
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2. METHOD AND NUMERICAL MODEL. 2.1
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1 u dV V u. (Eq. 2) V The permeab
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1. ABSTRACT PASSIVE AND ACTIVE MUSC
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presented in figure 2 the simulatio
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Indenter Stroke [mm] Muscle Force [
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Objectives Long bone failure charac
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the specimens in three point bendin
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developing a subject-specific finit
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Models used in the past, mostly bas
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In this work it is presented the de
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Average Table 1.- Walk average test
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angles for the step of 2.28° and 8
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insufficiency syndrome (TIS), defin
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a) b) c) Fig. 5 - Contact interface
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EOS. Among these options, VEPTR has
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dissection occurs when blood intrud
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mean value of 0.0310 m s -1 . The o
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progression. It can in turn contrib
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dependent data. They conclude that
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found that it is extremely difficul
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endering loop is started and the ra
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3.1 Imaging protocol of the knee A
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Fig. 3: Pressure distribution in th
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7. REFERENCES 1. Masouros, S.D., Bu
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and estimate in vivo tissue strains
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tendon has a larger moment arm abou
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Song, H. M., Smith, R. L., Longaker
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Fig. 1. Single line transducer resu
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Let P INT be the data set of the lo
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could quantify the initial structur
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expansion of a stent, a metallic sc
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immediately after stent expansion a
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6. ACKNOWLEDGMENT This research is
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Deformation of the arterial surface
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separate study to be described in a
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3. Timmins, L.H., Miller M.W. Clubb
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migrate in a unique fashion to the
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Fig. 1: Domain and schematic repres
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Furthermore, the values are spread
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this study, our goal is to establis
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Figure 3. Relative length change in
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5. Erdemir A, Sibole S. Open Knee:
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lateralis (inferior and superior) f
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during mouth closing and chewing. O
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BIOMECHANICAL MODELING OF THE HUMAN
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appropriates mechanical properties
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Fig. 4: Correlation of the location
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1. ABSTRACT COMPUTER AIDED TUMOR RE
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B. Cutting planes The surgeon defin
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4.RESULTS To test the developed sys
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FROM PATIENT-SPECIFIC DATA TO MULTI
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catheterization mean measurements (
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the different virtual surgical desi
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1. ABSTRACT DIGITAL ULTRASOUND DESP
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2.2 Filtering Based Wavelet 2.2.1 C
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Table 1: quantitative criteria used
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Mural Thrombosis in a Two-Level Com
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But, the soft repulsive force can n
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Ratio of adhered PLT a simplificati
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DEGRADATION OF MAGNESIUM ALLOY STEN
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study and the parameter setting can
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Fig. 5. Damage evolution of the thr
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NUMERICAL SIMULATIONS OF FATIGUE FO
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Figure 1. Scheme of the two approac
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Figure 3. On the left, alternating
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INVESTIGATION OF HEAD-NECK KINEMATI
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complexity of the vertebrae and sku
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nearly no tension occurred for the
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9. Ito S, Ivancic PC, Panjabi MM, C
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[Ntsinjana et al., 2011], commonly
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impedances were maintained within p
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6. Pennati G., Corsini C., Cosentin
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analyse the effect that different a
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attached cases this value was highe
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References 1. Nordin M and Frankel
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therapy to achieve the desired medi
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iomechanical response of the leg to
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algorithm has to be integrated into
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to a modification in the tooth disp
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5. CONCLUSIONS 5.1 Geometry and per
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present work is to show the ability
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[6,7]. In order to reproduce numeri
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5. DISCUSSION, CONCLUSIONS AND PERS
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3.1 Generation of the vertebral sur
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3.4 Modeling of the facet joints Th
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The column diagramm of Fig.8 shows
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tool to evaluate the drug distribut
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Figure 3: The mean value of the dos
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INFLUENCE OF KYPHOSIS ON SPINAL LOA
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(a) (b) (c) Fig. 1. The three repre
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etween T6 and T9 with a higher degr
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A COMPARISON BETWEEN STANDARD AND D
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the SB with a 2.5 mm balloon; ii) o
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A TAWSS [Pa] B OSI [Pa] C 0 0.25 0.
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ABSTRACT CONSTITUTIVE MODELLING OF
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20% compression strains were impose
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4. DISCUSSION The limited number of
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AN ALGORITHM FOR MODELING THE FIBRE
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1 - Compute the centre of the botto
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(a) (b) Figure 2. Load-displacement
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A bio-mechanics based methodology t
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to a particular body part based on
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Injury Cost (USD) Million 0.7 0.6 0
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A SENSITIVITY ANALYSIS OF ADAPTIVE
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elationships can be found that rela
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Fig. 2: Percentage of bone volume w
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APPLICATION OF REACTION-DIFFUSION W
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AIRFLOW VENTILATION THROUGH HUMAN M
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solve all the governing equations.
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Fig. 4 Streamlines through the osti
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MOLECULAR DYNAMICS SIMULATIONS FOR
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COARSE-GRAINED MOLECULAR DYNAMICS S
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DESIGN AND STRUCTURAL EVALUATION OF
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Figure 2 shows the optimal unit-cel
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ENUM (MPa) 100 90 80 70 60 50 40 30
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vivo menisco-tibial kinematics duri
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Loading the fully extended knee wit
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is also subject to variation due to
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environment in comparison to fixed
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4. RESULTS AND DISCUSSION Convergen
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Because of the orthotropic assumpti
Page 747 and 748:
3D RECONSTRUCTION OF STENTED PORCIN
Page 749 and 750:
Fluid model. The final configuratio
Page 751 and 752:
Table 1: Computed slice measurement
Page 753 and 754:
ANALYSIS OF THE EFFECT OF CONSIDERI
Page 755 and 756:
For all these models, C1 = µ/2, µ
Page 757 and 758:
the difference in percentage betwee
Page 759 and 760:
A COMPUTATIONAL METHOD TO ESTIMATE
Page 761 and 762:
C10, C01 and d were taken from [10]
Page 763 and 764:
4. RESULTS Fig. 2 shows the results
Page 765 and 766:
COMPUTATIONAL AND EXPERIMENTAL MODE
Page 767 and 768:
data using commercial software (Mim
Page 769 and 770:
vitro (40 vs 34%), at the expense o
Page 771 and 772:
FINITE ELEMENT ANALYSES OF IN VIVO
Page 773 and 774:
The non-linear behaviour of the art
Page 775 and 776:
Figure 6. Constant-life diagram for
Page 777 and 778:
Optimal acceleration adjustment to
Page 779 and 780:
, , , ,
Page 781 and 782:
The vertical force bump observed du
Page 783 and 784:
NEURAL NETWORK-BASED PREDICTION OF
Page 785 and 786:
3. MATERIAL AND METHODS 3.1 Experim
Page 787 and 788:
from subjects S1, S2, S3, S5, and S
Page 789 and 790:
APPLICATION OF A MODIFIED ELASTIC F
Page 791 and 792:
h and h being the thickness of the
Page 793 and 794:
0.3 were used for the flat surface
Page 795 and 796:
simulations of the mechanical respo
Page 797 and 798:
50000 images have been acquired. Th
Page 799 and 800:
Fig.1 Modules of the proposed capsu
Page 801 and 802:
5. CONCLUSION This paper describes
Page 803 and 804:
dependent on the implementation of
Page 805 and 806:
joint computer model was driven wit
Page 807 and 808:
otation. The AP laxity test showed
Page 809 and 810:
A COMPUTATIONAL MODEL OF THE GROWTH
Page 811 and 812:
where n p is the number of prolifer
Page 813 and 814:
Hypertrophic columnar cartilage 0.2
Page 815 and 816:
SIMULATION OF DAILY LIVING MOVEMENT
Page 817 and 818:
otations were kept at zero, since t
Page 819 and 820:
cavity (van der Helm, 1994). Howeve
Page 821 and 822:
Solving Overconstrained Kinematic i
Page 823 and 824:
3.3. Muscles Muscles are modelled a
Page 825 and 826:
5. DISCUSSION A musculoskeletal num
Page 827 and 828:
EFFECT OF OSCILATORY FLOW ON MORPHO
Page 829 and 830:
dimensionless frequency . With the
Page 831 and 832:
Wntsignaling, J Clin Invest., 2006,
Page 833 and 834:
Maximization (EM) algorithm witch e
Page 835 and 836:
4. RESULTS: n 1 2 x f ( x ; )
Page 837 and 838:
5. CONCLUSION In this work, a semi-
Page 839 and 840:
allow cell construct image inspecti
Page 841 and 842:
formula can be written as a linear
Page 843 and 844:
( ) (4) Poisson‟s ratio was assum
Page 845 and 846:
a) b) c) d) Figure 7 Validation: a)
Page 847 and 848:
DEVELOPMENT OF A NEW COMPUTATIONAL
Page 849 and 850:
The ScanIP wizard creates the new i
Page 851 and 852:
Fig. 5: Computer experiments: poste
Page 853 and 854:
A BIOMECHANICAL CONCEPT FOR CONSTRU
Page 855 and 856:
Figure 3. Construction of the radia
Page 857 and 858:
6. REFERENCES 1. Lees, S., A study
Page 859 and 860:
from cadaver surgeries were recreat
Page 861 and 862:
mean resection parameters and the p
Page 863 and 864:
5. DISCUSSION This study proposes a
Page 865 and 866:
simulations are evaluated by quanti
Page 867 and 868:
improvement of the shoulder prosthe
Page 869 and 870:
13. Coley B., Jolles B. M., Farron
Page 871 and 872:
simulations. Implicit in this setup
Page 873 and 874:
assigned zero fluid pressure bounda
Page 875 and 876:
the efficacy of predicting cellular
Page 877 and 878:
Another important function of the l
Page 879 and 880:
The insert (Fig. 3) is the part aga
Page 881 and 882:
changes due to the testing conditio
Page 883 and 884:
3. IN VIVO MEASURED LOAD COMPONENTS
Page 885 and 886:
anthropometric data - a data set fo
Page 887 and 888:
COMPUTATIONAL MODELING OF HIGHLY PO
Page 889 and 890:
objects smaller than one tenth of a
Page 891 and 892:
as 221.5 MPa. This value is more th
Page 893 and 894:
Macrostress and Macrostrain Finite
Page 895 and 896:
3.2. Extraction of individual artic
Page 897 and 898:
Unique strain patterns were observe
Page 899 and 900:
poroviscoelastic simulation of the
Page 901 and 902:
anchorage of the cartilage into a p
Page 903 and 904:
load of 0.5 N) resulted in a 55 kPa
Page 905 and 906:
properties as well as protect the h
Page 907 and 908:
Dynamic cell seeding combines two c
Page 909 and 910:
order (PB). The particles adhered (
Page 911 and 912:
2. D. Wendt, A. Marsano, M. Jakob,
Page 913 and 914:
2. Only a few high-level clinical s
Page 915 and 916:
A quasi-static analysis was perform
Page 917 and 918:
e increased by using stiffer or tig
Page 919 and 920:
Despite the importance of taking th
Page 921 and 922:
Table 2: Score chart presented to t
Page 923 and 924:
We conclude that the model develope
Page 925 and 926:
presented system - parallelization
Page 927 and 928:
image is projected to the subsequen
Page 929 and 930:
6. CONCLUSIONS The presented in the
Page 931 and 932:
first simulation uses data provided
Page 933 and 934:
Table 1: Models used in this study.
Page 935 and 936:
direction at knee extension, placin
Page 937 and 938:
3. METHODS 3.1. Model of heat trans
Page 939 and 940:
condition before and after heating.
Page 941 and 942:
during daily activities reported in
Page 943 and 944:
samples of brain tissue were extrac
Page 945 and 946:
5. DETERMINING MECHANICAL PROPERTIE
Page 947 and 948:
2001, Vol. 38 (4), 335-345. 8. Vela
Page 949 and 950:
chamber [4]. After obtaining the va
Page 951 and 952:
4. RESULTS 4.2 Surface and solid me
Page 953:
7. ACKNOWLEDGMENTS Financial fundin
Page 956 and 957:
affect crack penetration into osteo
Page 958 and 959:
Therefore, in order to examine the
Page 960 and 961:
3. Mischinski, S., Ural, A., 2011,
Page 962 and 963:
esearchers. The power of a finite-e
Page 964 and 965:
figure 2, we can determine the node
Page 966 and 967:
architecture, Muscle & Nerve, 2004,
Page 968 and 969:
ensure good short-term and long-ter
Page 970 and 971:
Table I - Micromotion results at th
Page 972 and 973:
COMBINED BONE-IMPLANT FIXATION: A P
Page 974 and 975:
FRICTIONAL PROPERTIES OF OSTEOARTHR
Page 976 and 977:
With the following boundary conditi
Page 978 and 979:
pressures higher than normal contac
Page 980 and 981:
1. ABSTRACT DYNAMIC PRESSURE RESPON
Page 982 and 983:
quasi-static solution, and both pos
Page 984 and 985:
(excluding the cadaveric validation
Page 987 and 988:
AN ANALYTICAL MODEL TO INVESTIGATE
Page 989 and 990:
K sh = 2. 3E sh 2 ( ) 2 1 2 1−ν
Page 991 and 992:
Fig. 7 modeling the oblique impact
Page 993 and 994:
A NON-LINEAR BIPHASIC MODEL FOR THE
Page 995 and 996:
system, it is convenient to write t
Page 997 and 998:
only with very small damping parame
Page 999 and 1000:
A PARAMETERIZED FE MODEL FOR SIMULA
Page 1001 and 1002:
the study of Polikeit et al. [10].
Page 1003 and 1004:
There are obvious limitations to ou
Page 1005 and 1006:
Abnormal stresses are often cited a
Page 1007 and 1008:
4. RESULTS The methods used to meas
Page 1009 and 1010:
that muscle imbalance associated wi
Page 1011 and 1012:
BIOCHEMICAL MODEL TO PREDICT THE ON
Page 1013 and 1014:
3.1 Model description The regulator
Page 1015 and 1016:
[3] Shier D., 2001, Hole’s Human
Page 1017 and 1018:
Biomechanics of Human Gluteal Tissu
Page 1019 and 1020:
information. Based on the indentati
Page 1021 and 1022:
t 1 ⎧⎪ ⎫ 2 2 ⎪ ττττ ( t
Page 1023 and 1024:
REFERENCES 1. Gefen A., Gefen N., L
Page 1025 and 1026:
analysis of the large-scale human m
Page 1027 and 1028:
λ σ = σ (8) act isom f f 0 ⋅
Page 1029 and 1030:
In the absence of membranes, the mu
Page 1031 and 1032:
predicted. This is possible for mod
Page 1033 and 1034:
-7.2 mN. The average value of the m
Page 1035:
efore the joint moment reaches zero
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