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ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

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This model was used to indicate muscle behavior during ischemia and it is one of the<br />

capabilities of this model. As it is obvious ischemia is any condition that prevents blood<br />

from reaching organs and tissues of the body. Blood contains oxygen and many<br />

nutrients. Without these components, these tissues will begin to die. The three major<br />

pathophysiological conditions of ischemia are: elevated [K +]o, acidosis and anoxia.<br />

Since [K + ]o is a constant parameter in electrochemical model [20], we can easily make<br />

the muscle ischemic by elevated [K + ]o. The [K + ]o concentration varies from 4.5 mM to<br />

35 mM and it depends on ischemia intensity. It means that if [K + ]o is 4.5 mM, the<br />

muscle won't be ischemic and if it is 35 mM, it will be ischemic. As illustrated in Figure<br />

4 the muscle that is ischemic, there are large deformations so this occurrence causes<br />

more stresses on the muscle. On the other hand, the muscle which is ischemic, resisting<br />

against electromechanical stimulation propagation so the peak of the ischemic muscle<br />

curve is in the front of the other and its response to stimulation is delayed. This response<br />

is compatible with ref [20].<br />

Fig 4: Influence of ischemia on the muscle contraction<br />

At the end of this part we should mention the capabilities of proposed model. Excitation<br />

location is definable and we can see the effect of variations in excitation value,<br />

excitation frequency, as well as we can see the effect of drug consumption in the muscle<br />

contraction ( drug consumption restrict the channels).<br />

5. FUTURE WORK<br />

Further research is needed to improve muscle geometry. It is needed to investigate how<br />

changed muscle contraction pattern by changing the other ions concentration in<br />

electrochemical model and of course we can simulate muscle contraction by drug<br />

consumption.<br />

8. REFERENCES<br />

Ischemic muscle<br />

[1]. Marieb E., Human Anatomy and Physiology. The Benjamin/Cumming Publishing,<br />

California, 1995.<br />

[2]. Lieber R., Friden J., Functional and clinical significance of skeletal muscle

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