ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

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OPEN KNEE: CAPACITY TO REPRODUCE ANTERIOR CRUCIATE LIGAMENT DEFORMATIONS 1. ABSTRACT A. Erdemir 1,2 and S. Sibole 3 Simulation-based explorations of the knee have commonly relied on finite element analysis. For example, for the anterior cruciate ligament, studies explored injury mechanisms, impingement, and load transmission. Finite element analysis of the knee requires a model representative of joint and tissue level mechanics. In this study, our goal was to establish the predictive capacity of Open Knee, an openly developed and disseminated tibiofemoral joint model, for specimen-specific representation of anterior cruciate ligament deformation. Specimen-specific mechanical testing data, representative of a 100 N anterior drawer test at 0° and 30° flexion angles, were utilized. The data set included ligament length change acquired with a DVRT (MicroStrain, Inc., Williston, VT) placed on the anteromedial bundle. The loading and boundary conditions of the experiment were reproduced in simulations. The association of model predicted ligament length changes against those measured by the DVRT was established by linear regression. While predicted and measured ligament deformations were highly correlated, simulations consistently overestimated relative change in anterior cruciate ligament length. Overpredictions were more pronounced for initial and high loading levels but less for the middle range. It is possible that current representation of the anterior cruciate ligament and also that of other anatomical structures, e.g. menisci, particularly related to assignment of generic material properties, may describe such discrepancies. Future work, to test such statements is planned, and can also be accomplished by others, given the open nature of development and dissemination of the knee model. 2. INTRODUCTION Simulation-based exploration of knee biomechanics has commonly relied on finite element analysis. For the anterior cruciate ligament (ACL), many modeling studies have been conducted to explore injury mechanisms [1], impingement [2], and load transmission [3]. Like any other modeling studies, finite element analysis of the knee and its components requires a robust model representative of joint and tissue level mechanics [4]. Recently, we have openly developed and disseminated a finite element representation of the tibiofemoral joint, Open Knee (https://simtk.org/home/openknee) [5], and explored its capacity to reproduce normative passive joint kinematics [6]. In 1 Director, Computational Biomodeling (CoBi) Core, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44118, USA 2 Assistant Staff, Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44118, USA 3 Research Engineer, Computational Biomodeling (CoBi) Core and Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44118, USA
this study, our goal is to establish the predictive capacity of Open Knee for specimenspecific representation of gross ACL deformation during an anterior drawer test. A successful evaluation process will increase confidence in finite element analysis of the knee underline in situ behavior of the ACL. It will also establish a computational tool for virtual prototyping of interventions to reproduce this ligament's biomechanical function. Even when unsuccessful, a detailed depiction of model's failure to reproduce experimental results will potentially identify directions for model improvement. 3. METHODS Open Knee, a finite element representation of the tibiofemoral joint, was reconstructed from a right cadaver knee (70 year old female, 77.2 kg) [5] (Figure 1). For the same knee, mechanical testing data representative of anterior drawer were also available [7]. For this study, anterior laxity data acquired at 0° and 30° flexion (all other tibiofemoral joint degrees of Figure 1. Components of Open Knee, a finite element representation of the tibiofemoral joint, as shown from a posterior view, from Open Knee User's Guide [5]. In this study, contact between collateral ligaments and bone/menisci were not modeled. The experimental scenario for anterior drawer test was replicated by the application of a posterior force on the femur at the origin of the femoral coordinate system. Flexion was prescribed; the rest of femoral rigid body degrees of freedom were set free; tibia was fixed. freedom free), for a 100 N tibial load (with 10 N increments) were utilized. The data set included gross measurements of ACL length change, acquired with a DVRT (MicroStrain, Inc., Williston, VT). The DVRT was placed on the anteromedial bundle of the ACL, with the distal end approximately 3 mm above the tibial insertion and the proximal end approximately 11 mm proximal to distal end of the DVRT [7]. Time history of the loading and boundary conditions of the experiment were reproduced in the finite element analysis, utilizing approximately the same joint coordinate system [8]. FEBio (http://www.febio.org), a nonlinear finite element analysis software package for biomechanics, was used for implicit dynamic simulations. Predicted ACL deformations were calculated from the distance between nodes representative of DVRT insertion points on the model (Figure 2). For both the model and experiment, and at both flexion angles, the relationship between anterior drawer force and ACL length change was established. The association of model predicted change in ACL length against those measured by DVRT was conducted by scatter plot regression, separately for 0° and 30° flexion [4]. Kinematics of the tibiofemoral joint were also quantified as a function of anterior drawer force, utilizing the Grood and Suntay convention [8].
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The Proceedings of the 10 th Intern
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Install Adobe Reader 8 or 9 (http:/
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Content: POSTERS: BRAIN: CELL: EVAL
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Modeling of blood flow through a fl
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The mesh generation of the model wa
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Figure6 . The stroke volume data fo
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Digital Subtraction Phonocardiograp
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mobile cart for easy recording in c
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Figure 7. This image shows PCG samp
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Our approach is an improvement in t
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one cements as well as its behaviou
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Typical dimensions of lumbar verteb
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attributed to the change of stiffne
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lifestyle and obesity. In that cont
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T was the temperature in Kelvin and
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sustained tensile strains stimulate
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An approach aiming at determining a
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failure load. 2.4 Simulation of reh
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REFERENCES 1. Vunjak-Novakovic G, A
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3. FIF-BAL BIOREACTOR The FIF devic
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value of p nearest to dqc=0 we cont
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(Wanless, 1999). This low value cou
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3. MATERIALS AND METHODS A CAD mode
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did not allow gap closure. Maximum
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hand, if the IFM is too large, remo
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2. INTRODUCTION Intervertebral disc
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Figure 3. T1 signal enhancement in
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1. ABSTRACT TIP CELLS AT THE TOP: M
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Fig. 1. Schematic overview of the m
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Fig. 3. Image of the amount of VEGF
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THE COMPUTATIONAL MODEL OF DENTAL I
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processing application STL Model Cr
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For the implant/bone interaction as
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ABSTRACT THE IMPACT OF SELECTION BI
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Figure 1: flow chart showing the op
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Figure 2: Time course of cytosolic
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CONSTITUTIVE MODELLING OF THE ANNUL
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it is well known the non-linear nat
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Therefore, we have decided to carry
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EXTRACTION OF PHALANGEAL JOINT PARA
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column vectors of P. Denoting the v
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End i joint angles and length offse
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Validation of Strain Mapping for th
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allows the calculation of strain ma
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RMS error was 0.054 and the strains
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AN APPROACH FOR THE REDUCTION OF TH
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The relation between the time-deriv
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Error in position [mm] Error in pos
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ANALYSIS OF THE INTRAINDIVIDUAL DIF
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Fig.1: Frontal view on all subchond
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[6] M. Bozkurt, B. B. Kentel, G. Ya
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on the actual necessary time needed
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Illustration 2: The initially spher
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cell if it is hardly able to deform
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fit with a reference anatomy in min
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show that patellar mal-positioning
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Experimental and numerical analysis
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stenosis in both simulations and ex
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stented case, corresponding to the
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EVALUATION OF DIFFERENT LOADING CON
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were modeled with identical geometr
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each simulation and the position of
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FINITE ELEMENT MODEL ANALYSIS OF HU
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Figure 1: Maximal principal strains
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Method for classification of porcin
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3.3 Identification of Paths Accordi
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Table. 1. Descriptive Patterns used
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CHARACTERIZING THE MECHANICAL MICRO
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3.1.3 Cell proliferation It is assu
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Stress [Pa] 4 3 2 1 0 Mean stress A
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REFERENCES [1] A.M. Bratt-Leal, R.L
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y exposure to interstitial fluid sh
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according to (Eq. 2), nor averaged
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emoved the oscillations partially a
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static load and a dynamic load. A s
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positive effect of the number of ac
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pathways and their interactions tha
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applications, the need for accuracy
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avoid violating the initial geometr
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6. CONCLUSION The examples of appli
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Fig. 1 Semicircular canal structure
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4. RESULT Fig. 6 FSI model of semic
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6. ACKNOWLEDGEMENT This research wa
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ods to the biocompatible plastic po
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Table 1: Analysis conditions Static
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[3] Brantigan, J. W., Steffee, A. D
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femoral head fracture, the femoral
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Fig 3. Schematic drawing of the ste
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6. CONCLUSION Fig 7. Analysis resul
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and angular rates were registered b
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former, there were assumed the foll
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delivered dynamic support, which pr
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insertion of provisional restoratio
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Figure 4: Implant displacements obt
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5. DISCUSSION AND CONCLUSION Initia
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at which microdamage originates. Fo
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4. RESULTS The load response varied
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current study to explore the effect
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implant correctly from the finite e
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(a) (b) (c) (d) (e) Figure 3. The s
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(a) (b) Figure 6. The meshed model
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(a) (b) Figure 9. Cumulative probab
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NUMERICAL EVALUATION AND MEDICAL CO
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compared by overlaying the real dat
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four sample patient data, outcomes
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A POROELASTIC APPROACH FOR AN OPEN
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where indexes U, P refer to the unk
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RESULTS As a preliminary test, a 0.
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BIOMECHANICAL BEHAVIOR OF CANCELLOU
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cement acts perfectly, therefore it
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cancellous bone of natural joints a
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COMPUTATIONAL MODELING OF TANGLED A
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The centers of the simulated cells
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untangled, the local fiber displace
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TOWARDS A WAVELET BASED MEDICAL IMA
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however at each decomposition scale
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the MATLAB software (for the Modifi
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A FLUID STRUCTURE INTERACTION MODEL
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hyperelastic based on available exp
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t [ms] 30 70 160 220 270 Pressure [
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MECHANICAL BAHAVIOR OF DIFFERENT NI
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parameters necessaries to use this
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F1 and Mtwo were directly related t
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MECHANICAL EFFECT ON METABOLIC TRAN
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an initial nil lactate concentratio
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present study, such values were phe
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EVALUATION OF FEMORAL COMPONENT MIC
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TS implants employed a “hybrid”
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5. DISCUSSION i ii Figure 2: Compar
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THE MECHANICAL ENVIRONMENT IN THE D
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instead the femur was supported by
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It must be noted however, that in t
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1. ABSTRACT MODELING OF ARTICULAR C
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exp 1 1 2 1 where and are i
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Implant Fig.2. Axisymmetric represe
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A MULTI-SCALE ANISOTROPIC CONSTITUT
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3.2 Decoupled invariant formulation
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Fig. 1. Experimental data from unia
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VALIDATION AND CALIBRATION PROCESSE
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Figure 1: A three-step process simu
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The validation process employed on
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FLUID-STRUCTURE INTERACTION ANALYSI
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The coupled SQA model and the conve
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Point P7, located at the toe of the
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THE INFLUENCE OF UNCERTAIN ANATOMIC
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Figure 3 exemplifies for intradisca
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8. CONCLUSIONS Unsurprisingly, the
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COMPARISON OF DIFFERENT LOADING CON
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Figure 1 Finite element model of th
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6 CONCLUSION It is a feasible way t
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FROM CELL CONTRACTILITY TO CURVATUR
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4. MODEL When cells adhere on a sub
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organisation. Understanding the pri
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PREOPERATIVE PLANNING SUPPORT SYSTE
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[9]. Stenosis of 25, 45, 65 and 85
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Fig. 1:Dependent and independent va
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1. ABSTRACT Local strain measuremen
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around 100µm (halfway through the
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sampling points at different cross
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CLASSIFICATION OF PHYSICAL ACTIVITY
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induces a vertical alignment of the
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accelerations combination). However
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line under translation. Information
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In this study, we apply a meshless
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used the PAC constitutive constants
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1006031) is gratefully acknowledged
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improvements were seen in both grou
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Pre-augmentation Position 1, V=3mL
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5. ACKNOWLEDGEMENTS Funding for thi
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the hemodynamics in cerebral aneury
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4. RESULTS AND DISCUSSION In order
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processing methods need to be devel
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3. METHODS 3.1 Experimental Method
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Figure 2 - Micrographs for tensile
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analysis of the tissue mechanics. B
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3. METHODS 3.1 Specimen Preparation
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of five points across the mid mid-c
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equired to replicate the deformatio
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pre-load within the plate (compress
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4. RESULTS The load-deformation beh
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fracture fixation. Medical Engineer
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model. It approximates knee kinemat
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computational cost remains moderate
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Concerning the optimization procedu
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aesthetic recovery. However, in som
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atio experimented by both wounds is
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VARIATION OF MICRO-ARCHITECTURE AND
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osteoporotic (OP). The sample volum
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Figure 4: Mean error in orthotropy
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INVESTIGATION OF CORTICAL SHELL STR
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When creating the degenerated FE mo
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Figure 4. Degeneration sensitivity
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METHODS TO ACCELERATE FINITE ELEMEN
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the “joint” constraints configu
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Figure 4: Absolute prediction error
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EFFECT OF POST TREATMENT FOR MULTIP
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Fig.2 Inlet velocity profile indica
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4.3 WSS results Figure 8 shows the
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approximated by the so-called Ritz
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Figure 2: Viscohyperelastic cube: (
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There is no optimal density-elastic
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Fig. 2 Cut view of FE-model. Shown
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5. Weis JA, Miga MI, Granero-Moltó
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3. SYSTEM DESIGN Sheep eyes, as the
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which provides natural tactile feed
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113:341-342 20. Henderson B. A., Gr
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health area. According to estimates
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Table 1. RMS Value based on subject
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6. REFERENCES 1. http://www.disable
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ehavior [5]. From the viewpoint of
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Fig. 1 Average Male and Female's L4
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4. Deyo, R.A., and Weinstein, J. N.
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geometry of the cell and ECM degrad
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Shown in Fig. 2(b) is a plot of the
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6. REFERENCES 1. Dubin-Thaler B.J.,
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We implemented our individual-based
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3.3.1 Centers of mass Table 1: Base
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average coordination num ber averag
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BIOMECHANICAL ANALYSIS OF THE MUSCU
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of the ligament strain; a linear re
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lengthening, respectively, if compa
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THE EFFECT OF HIGH TIBIAL OSTEOTOMY
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The 3D LiveWire tool was used as an
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Table II: Peak medial and lateral f
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INVESTIGATING CHANGES IN JOINT LOAD
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4. RESULTS Table 1 shows the mean m
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Fig.5 displays the OKS and KOS pre
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Dynamic Touch of Effective Golf Swi
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properties of a golf club and hand
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perturbation in e3 whereas player B
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1. Kim, W., Response to letter to t
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configuration.[4] have explained ho
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compartments as well as a single mu
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5. Shabana, A.A., Dynamics of multi
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Five healthy volunteers (age: 38.3
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internal lumbar spinal shape was de
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Airflow Simulation of Nasal Cavity
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temperature [5], and Wbl is the wat
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Figure 8. Figure 8(a) illustrates t
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Finite element models of the hip ca
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3.2 Finite Element Analysis Followi
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5. DISCUSSION Previous DEA implemen
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STATISTICAL SHAPE MODELING OF CAM-T
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Thirty-three control femurs (25 mal
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asymptomatic subjects 7,9 . The Hot
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6. REFERENCES 1. Ganz, R., Parvizi,
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NUMERICAL IDENTIFICATION OF THE PER
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2. METHOD AND NUMERICAL MODEL. 2.1
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1 u dV V u. (Eq. 2) V The permeab
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1. ABSTRACT PASSIVE AND ACTIVE MUSC
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presented in figure 2 the simulatio
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Indenter Stroke [mm] Muscle Force [
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Objectives Long bone failure charac
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the specimens in three point bendin
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developing a subject-specific finit
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Models used in the past, mostly bas
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In this work it is presented the de
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Average Table 1.- Walk average test
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angles for the step of 2.28° and 8
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insufficiency syndrome (TIS), defin
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Page 531 and 532: EOS. Among these options, VEPTR has
Page 533 and 534: dissection occurs when blood intrud
Page 535 and 536: mean value of 0.0310 m s -1 . The o
Page 537 and 538: progression. It can in turn contrib
Page 539 and 540: dependent data. They conclude that
Page 541 and 542: found that it is extremely difficul
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Page 545 and 546: 3.1 Imaging protocol of the knee A
Page 547 and 548: Fig. 3: Pressure distribution in th
Page 549 and 550: 7. REFERENCES 1. Masouros, S.D., Bu
Page 551 and 552: and estimate in vivo tissue strains
Page 553 and 554: tendon has a larger moment arm abou
Page 555 and 556: Song, H. M., Smith, R. L., Longaker
Page 557 and 558: Fig. 1. Single line transducer resu
Page 559 and 560: Let P INT be the data set of the lo
Page 561 and 562: could quantify the initial structur
Page 563 and 564: expansion of a stent, a metallic sc
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Page 567 and 568: 6. ACKNOWLEDGMENT This research is
Page 569 and 570: Deformation of the arterial surface
Page 571 and 572: separate study to be described in a
Page 573 and 574: 3. Timmins, L.H., Miller M.W. Clubb
Page 575 and 576: migrate in a unique fashion to the
Page 577 and 578: Fig. 1: Domain and schematic repres
Page 579: Furthermore, the values are spread
Page 583 and 584: Figure 3. Relative length change in
Page 585 and 586: 5. Erdemir A, Sibole S. Open Knee:
Page 587 and 588: lateralis (inferior and superior) f
Page 589 and 590: during mouth closing and chewing. O
Page 591 and 592: BIOMECHANICAL MODELING OF THE HUMAN
Page 593 and 594: appropriates mechanical properties
Page 595 and 596: Fig. 4: Correlation of the location
Page 597 and 598: 1. ABSTRACT COMPUTER AIDED TUMOR RE
Page 599 and 600: B. Cutting planes The surgeon defin
Page 601 and 602: 4.RESULTS To test the developed sys
Page 603 and 604: FROM PATIENT-SPECIFIC DATA TO MULTI
Page 605 and 606: catheterization mean measurements (
Page 607 and 608: the different virtual surgical desi
Page 609 and 610: 1. ABSTRACT DIGITAL ULTRASOUND DESP
Page 611 and 612: 2.2 Filtering Based Wavelet 2.2.1 C
Page 613 and 614: Table 1: quantitative criteria used
Page 615 and 616: Mural Thrombosis in a Two-Level Com
Page 617 and 618: But, the soft repulsive force can n
Page 619 and 620: Ratio of adhered PLT a simplificati
Page 621 and 622: DEGRADATION OF MAGNESIUM ALLOY STEN
Page 623 and 624: study and the parameter setting can
Page 625 and 626: Fig. 5. Damage evolution of the thr
Page 627 and 628: NUMERICAL SIMULATIONS OF FATIGUE FO
Page 629 and 630: Figure 1. Scheme of the two approac
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Figure 3. On the left, alternating
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INVESTIGATION OF HEAD-NECK KINEMATI
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complexity of the vertebrae and sku
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nearly no tension occurred for the
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9. Ito S, Ivancic PC, Panjabi MM, C
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[Ntsinjana et al., 2011], commonly
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impedances were maintained within p
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6. Pennati G., Corsini C., Cosentin
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analyse the effect that different a
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attached cases this value was highe
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References 1. Nordin M and Frankel
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therapy to achieve the desired medi
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iomechanical response of the leg to
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algorithm has to be integrated into
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to a modification in the tooth disp
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5. CONCLUSIONS 5.1 Geometry and per
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present work is to show the ability
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[6,7]. In order to reproduce numeri
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5. DISCUSSION, CONCLUSIONS AND PERS
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3.1 Generation of the vertebral sur
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3.4 Modeling of the facet joints Th
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The column diagramm of Fig.8 shows
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tool to evaluate the drug distribut
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Figure 3: The mean value of the dos
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INFLUENCE OF KYPHOSIS ON SPINAL LOA
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(a) (b) (c) Fig. 1. The three repre
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etween T6 and T9 with a higher degr
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A COMPARISON BETWEEN STANDARD AND D
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the SB with a 2.5 mm balloon; ii) o
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A TAWSS [Pa] B OSI [Pa] C 0 0.25 0.
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ABSTRACT CONSTITUTIVE MODELLING OF
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20% compression strains were impose
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4. DISCUSSION The limited number of
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AN ALGORITHM FOR MODELING THE FIBRE
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1 - Compute the centre of the botto
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(a) (b) Figure 2. Load-displacement
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A bio-mechanics based methodology t
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to a particular body part based on
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Injury Cost (USD) Million 0.7 0.6 0
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A SENSITIVITY ANALYSIS OF ADAPTIVE
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elationships can be found that rela
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Fig. 2: Percentage of bone volume w
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APPLICATION OF REACTION-DIFFUSION W
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AIRFLOW VENTILATION THROUGH HUMAN M
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solve all the governing equations.
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Fig. 4 Streamlines through the osti
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MOLECULAR DYNAMICS SIMULATIONS FOR
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COARSE-GRAINED MOLECULAR DYNAMICS S
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DESIGN AND STRUCTURAL EVALUATION OF
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Figure 2 shows the optimal unit-cel
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ENUM (MPa) 100 90 80 70 60 50 40 30
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vivo menisco-tibial kinematics duri
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Loading the fully extended knee wit
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is also subject to variation due to
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environment in comparison to fixed
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4. RESULTS AND DISCUSSION Convergen
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Because of the orthotropic assumpti
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3D RECONSTRUCTION OF STENTED PORCIN
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Fluid model. The final configuratio
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Table 1: Computed slice measurement
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ANALYSIS OF THE EFFECT OF CONSIDERI
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For all these models, C1 = µ/2, µ
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the difference in percentage betwee
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A COMPUTATIONAL METHOD TO ESTIMATE
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C10, C01 and d were taken from [10]
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4. RESULTS Fig. 2 shows the results
Page 765 and 766:
COMPUTATIONAL AND EXPERIMENTAL MODE
Page 767 and 768:
data using commercial software (Mim
Page 769 and 770:
vitro (40 vs 34%), at the expense o
Page 771 and 772:
FINITE ELEMENT ANALYSES OF IN VIVO
Page 773 and 774:
The non-linear behaviour of the art
Page 775 and 776:
Figure 6. Constant-life diagram for
Page 777 and 778:
Optimal acceleration adjustment to
Page 779 and 780:
, , , ,
Page 781 and 782:
The vertical force bump observed du
Page 783 and 784:
NEURAL NETWORK-BASED PREDICTION OF
Page 785 and 786:
3. MATERIAL AND METHODS 3.1 Experim
Page 787 and 788:
from subjects S1, S2, S3, S5, and S
Page 789 and 790:
APPLICATION OF A MODIFIED ELASTIC F
Page 791 and 792:
h and h being the thickness of the
Page 793 and 794:
0.3 were used for the flat surface
Page 795 and 796:
simulations of the mechanical respo
Page 797 and 798:
50000 images have been acquired. Th
Page 799 and 800:
Fig.1 Modules of the proposed capsu
Page 801 and 802:
5. CONCLUSION This paper describes
Page 803 and 804:
dependent on the implementation of
Page 805 and 806:
joint computer model was driven wit
Page 807 and 808:
otation. The AP laxity test showed
Page 809 and 810:
A COMPUTATIONAL MODEL OF THE GROWTH
Page 811 and 812:
where n p is the number of prolifer
Page 813 and 814:
Hypertrophic columnar cartilage 0.2
Page 815 and 816:
SIMULATION OF DAILY LIVING MOVEMENT
Page 817 and 818:
otations were kept at zero, since t
Page 819 and 820:
cavity (van der Helm, 1994). Howeve
Page 821 and 822:
Solving Overconstrained Kinematic i
Page 823 and 824:
3.3. Muscles Muscles are modelled a
Page 825 and 826:
5. DISCUSSION A musculoskeletal num
Page 827 and 828:
EFFECT OF OSCILATORY FLOW ON MORPHO
Page 829 and 830:
dimensionless frequency . With the
Page 831 and 832:
Wntsignaling, J Clin Invest., 2006,
Page 833 and 834:
Maximization (EM) algorithm witch e
Page 835 and 836:
4. RESULTS: n 1 2 x f ( x ; )
Page 837 and 838:
5. CONCLUSION In this work, a semi-
Page 839 and 840:
allow cell construct image inspecti
Page 841 and 842:
formula can be written as a linear
Page 843 and 844:
( ) (4) Poisson‟s ratio was assum
Page 845 and 846:
a) b) c) d) Figure 7 Validation: a)
Page 847 and 848:
DEVELOPMENT OF A NEW COMPUTATIONAL
Page 849 and 850:
The ScanIP wizard creates the new i
Page 851 and 852:
Fig. 5: Computer experiments: poste
Page 853 and 854:
A BIOMECHANICAL CONCEPT FOR CONSTRU
Page 855 and 856:
Figure 3. Construction of the radia
Page 857 and 858:
6. REFERENCES 1. Lees, S., A study
Page 859 and 860:
from cadaver surgeries were recreat
Page 861 and 862:
mean resection parameters and the p
Page 863 and 864:
5. DISCUSSION This study proposes a
Page 865 and 866:
simulations are evaluated by quanti
Page 867 and 868:
improvement of the shoulder prosthe
Page 869 and 870:
13. Coley B., Jolles B. M., Farron
Page 871 and 872:
simulations. Implicit in this setup
Page 873 and 874:
assigned zero fluid pressure bounda
Page 875 and 876:
the efficacy of predicting cellular
Page 877 and 878:
Another important function of the l
Page 879 and 880:
The insert (Fig. 3) is the part aga
Page 881 and 882:
changes due to the testing conditio
Page 883 and 884:
3. IN VIVO MEASURED LOAD COMPONENTS
Page 885 and 886:
anthropometric data - a data set fo
Page 887 and 888:
COMPUTATIONAL MODELING OF HIGHLY PO
Page 889 and 890:
objects smaller than one tenth of a
Page 891 and 892:
as 221.5 MPa. This value is more th
Page 893 and 894:
Macrostress and Macrostrain Finite
Page 895 and 896:
3.2. Extraction of individual artic
Page 897 and 898:
Unique strain patterns were observe
Page 899 and 900:
poroviscoelastic simulation of the
Page 901 and 902:
anchorage of the cartilage into a p
Page 903 and 904:
load of 0.5 N) resulted in a 55 kPa
Page 905 and 906:
properties as well as protect the h
Page 907 and 908:
Dynamic cell seeding combines two c
Page 909 and 910:
order (PB). The particles adhered (
Page 911 and 912:
2. D. Wendt, A. Marsano, M. Jakob,
Page 913 and 914:
2. Only a few high-level clinical s
Page 915 and 916:
A quasi-static analysis was perform
Page 917 and 918:
e increased by using stiffer or tig
Page 919 and 920:
Despite the importance of taking th
Page 921 and 922:
Table 2: Score chart presented to t
Page 923 and 924:
We conclude that the model develope
Page 925 and 926:
presented system - parallelization
Page 927 and 928:
image is projected to the subsequen
Page 929 and 930:
6. CONCLUSIONS The presented in the
Page 931 and 932:
first simulation uses data provided
Page 933 and 934:
Table 1: Models used in this study.
Page 935 and 936:
direction at knee extension, placin
Page 937 and 938:
3. METHODS 3.1. Model of heat trans
Page 939 and 940:
condition before and after heating.
Page 941 and 942:
during daily activities reported in
Page 943 and 944:
samples of brain tissue were extrac
Page 945 and 946:
5. DETERMINING MECHANICAL PROPERTIE
Page 947 and 948:
2001, Vol. 38 (4), 335-345. 8. Vela
Page 949 and 950:
chamber [4]. After obtaining the va
Page 951 and 952:
4. RESULTS 4.2 Surface and solid me
Page 953:
7. ACKNOWLEDGMENTS Financial fundin
Page 956 and 957:
affect crack penetration into osteo
Page 958 and 959:
Therefore, in order to examine the
Page 960 and 961:
3. Mischinski, S., Ural, A., 2011,
Page 962 and 963:
esearchers. The power of a finite-e
Page 964 and 965:
figure 2, we can determine the node
Page 966 and 967:
architecture, Muscle & Nerve, 2004,
Page 968 and 969:
ensure good short-term and long-ter
Page 970 and 971:
Table I - Micromotion results at th
Page 972 and 973:
COMBINED BONE-IMPLANT FIXATION: A P
Page 974 and 975:
FRICTIONAL PROPERTIES OF OSTEOARTHR
Page 976 and 977:
With the following boundary conditi
Page 978 and 979:
pressures higher than normal contac
Page 980 and 981:
1. ABSTRACT DYNAMIC PRESSURE RESPON
Page 982 and 983:
quasi-static solution, and both pos
Page 984 and 985:
(excluding the cadaveric validation
Page 987 and 988:
AN ANALYTICAL MODEL TO INVESTIGATE
Page 989 and 990:
K sh = 2. 3E sh 2 ( ) 2 1 2 1−ν
Page 991 and 992:
Fig. 7 modeling the oblique impact
Page 993 and 994:
A NON-LINEAR BIPHASIC MODEL FOR THE
Page 995 and 996:
system, it is convenient to write t
Page 997 and 998:
only with very small damping parame
Page 999 and 1000:
A PARAMETERIZED FE MODEL FOR SIMULA
Page 1001 and 1002:
the study of Polikeit et al. [10].
Page 1003 and 1004:
There are obvious limitations to ou
Page 1005 and 1006:
Abnormal stresses are often cited a
Page 1007 and 1008:
4. RESULTS The methods used to meas
Page 1009 and 1010:
that muscle imbalance associated wi
Page 1011 and 1012:
BIOCHEMICAL MODEL TO PREDICT THE ON
Page 1013 and 1014:
3.1 Model description The regulator
Page 1015 and 1016:
[3] Shier D., 2001, Hole’s Human
Page 1017 and 1018:
Biomechanics of Human Gluteal Tissu
Page 1019 and 1020:
information. Based on the indentati
Page 1021 and 1022:
t 1 ⎧⎪ ⎫ 2 2 ⎪ ττττ ( t
Page 1023 and 1024:
REFERENCES 1. Gefen A., Gefen N., L
Page 1025 and 1026:
analysis of the large-scale human m
Page 1027 and 1028:
λ σ = σ (8) act isom f f 0 ⋅
Page 1029 and 1030:
In the absence of membranes, the mu
Page 1031 and 1032:
predicted. This is possible for mod
Page 1033 and 1034:
-7.2 mN. The average value of the m
Page 1035:
efore the joint moment reaches zero
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ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

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