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ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

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mobile cart for easy recording in cardiology clinics and elsewhere. All sounds were<br />

recorded using the Goldwave software (Version 5.55), which includ es tools for<br />

recording, playing, filtering, and analyzing sounds. Using this software, we also deleted<br />

any electrical utility frequency (50 Hz) from the ECG recordings. We used MATLAB in<br />

conjunction with the signal processing and real-time data acquisition toolboxes as the<br />

computational heart of the system. Two time-adjacent phonocardiogram cycles, PCG-1<br />

and PCG-2,<br />

are obtained using the QRS complex of the ECG as a marker for the start of<br />

each cardiac cycle. The difference of the two PCG cycles is a murmurgram.<br />

Figure 2<br />

illustrates the PCG subtraction method.<br />

Amplit ude<br />

0 . 2<br />

0 . 1 5<br />

0 . 1<br />

0 . 0 5<br />

0<br />

- 0 . 0 5<br />

- 0 . 1<br />

- 0 . 1 5<br />

- 0 . 2<br />

1<br />

3 0<br />

5 9<br />

8 8<br />

11 7<br />

1 4 6<br />

C y c l e A<br />

Amplit ude<br />

1 7 5<br />

2 0 4<br />

S a m p l e s<br />

0 . 2<br />

0 . 1 5<br />

0 . 1<br />

0 . 0 5<br />

0<br />

- 0 . 0 5<br />

- 0 . 1<br />

- 0 . 1 5<br />

- 0 . 2<br />

1<br />

2 3 2 6 2<br />

2 5<br />

4 9<br />

2 9 1<br />

3 2 0<br />

7 3<br />

9 7<br />

3 4 9<br />

3 7 8<br />

1 2 1<br />

1 4 5<br />

1 6 9<br />

Amplit ude<br />

0 . 2<br />

0 . 1 5<br />

0 . 1<br />

0 . 0 5<br />

0<br />

- 0 . 0 5<br />

- 0 . 1<br />

- 0 . 1 5<br />

- 0 . 2<br />

1<br />

3 0<br />

5 9<br />

8 C y c l e A - C y c l e B<br />

1 9 3<br />

2 1 7<br />

S a m p l e s<br />

2 4 1<br />

2 6 5<br />

2 8 9<br />

3 1 3<br />

11 7<br />

3 3 7<br />

C y c l e B<br />

1 4 6<br />

1 7 5<br />

3 6 1<br />

2 0 4<br />

2 3 S a m p l e s<br />

Figure 2. The schematic of result of subtracting two successive heartbeats to construct a<br />

“murmurgram”.<br />

4. RESULTS<br />

Figure 4 shows samples of simulated PCGs (first & second panels) from a simulated<br />

healthy heart. The murmurgram and the corresponding color spectrogram are shown in<br />

the bottom two panels. Each simulated PCG is of 1 cardiac cycle covering an elapsed<br />

time of 0.7 second. Note that murmurgram is "flat" and has frequency components<br />

largely<br />

under 200 Hz. Two successive heartbeats of data for a simulated VSD case are<br />

shown in the first and second panels in Figure 5. The murmurgram (third panel)<br />

between S1and S2 isn`t "flat". The spectrographic graph, shown at the bottom of the<br />

figure, indicates<br />

that the murmur has frequency components extending to 700 Hz.<br />

Figure 6 shows PCGs from a simulated ASD case. The murmurgram and corresponding<br />

color spectrogram are shown in the bottom two panels. The simulated PCG is of 1<br />

cardiac cycle covering an elapsed<br />

time of 0.7 seconds. Note that the murmurgram isn`t<br />

"flat" between S1and S2. The mid systolic murmur in the murmurgram in this case has<br />

frequency components that extend to around 600 Hz.<br />

3 8 5<br />

2 6 2<br />

2 9 1<br />

3 2 0<br />

3 4 9<br />

3 7 8

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