ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

Ratio of adhered PLT
a simplification used is that only a single platelet can be detached.
5. Result and Discussion
Our model capability to capture the aggregation of platelets is shown in Fig.1. It is vivid
in some snapshots that the drag-dependent detachment function played very crucial role
in adapting the aggregation to flow regime. The Fig.1 can show mountain-like structure
of the aggregated platelets which was observed in in-vivo experiment of [12].
(a)
(c)
Fig.1; snapshots of aggregation of platelets; there are detachments between picture C and D.
The rate of adhesion, as can be seen in Fig.2, is constant in 60 seconds of simulation. It
is comparable with the previous study of Pivkin [6] and Goodmann et al. [13].
1.2
1
0.8
0.6
0.4
0.2
0
rate of PLT adhesion
0 20 40 60
time(s)
Fig.2; number of adhesion in time normalized by the total
number of adhesion
(b)
(d)
ratio of adhered PLT
0.3
0.25
0.2
0.15
0.1
0.05
Adhered PLT Distribusion
0
73 83 93 103
x(along lesion)
Fig.3; platelet distribution along the lesion; normalized
by the maximum number of aggregated platelet