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ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

ARUP; ISBN: 978-0-9562121-5-3 - CMBBE 2012 - Cardiff University

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affected by two reduction coefficients, the first one coupled with the circumferential<br />

position and the second one with the radial position of a given fiber on the AF. As a<br />

result, an anatomically-based gradient of the mechanical properties of the AF is defined,<br />

with clear advantages in terms of significance of the modeling and validity of the<br />

numerical results of the numerical analysis of the biomechanics of the IVD. The<br />

preliminary results seem to be in good agreement with the work of Sato et al. (1999).<br />

7. ACKNOWLEDGMENTS<br />

The authors gratefully acknowledge the support of the European Project: NP Mimetic -<br />

Biomimetic Nano-Fiber Based Nucleus Pulposus Regeneration for the Treatment of<br />

Degenerative Disc Disease, funded by the European Commission under FP7 (grant<br />

NMP3-SL-2010-246351).<br />

8. REFERENCES<br />

1. Urban, J. P. G. & Roberts, S. (2003). Degeneration of the intervertebral disc:<br />

Review. Arthritis Research & Therapy, 5, 120-130.<br />

2. Marchand F, Ahmed AM (1990) Investigation of the laminate structure of lumbar<br />

disc anulus fibrosus. Spine 15:402–410<br />

3. Holzapfel, G.A., Schulze-Bauer, C.A., Feigl, G., Regitnig, P. (2005) Single lamellar<br />

mechanics of the human lumbar annulus fibrosus. Biomech. Model. Mechanobiol 3:<br />

125-140.<br />

4. Sato K, Kikuchi S, Yonezawa T. (1999) In Vivo Intradiscal pressure measurement<br />

in healthy individuals and in patients with ongoing back problems. Spine<br />

24(23):2468-74.<br />

5. Karajan, N. (2009). An Extended Biphasic Description of the Inhomogeneous and<br />

Anisotropic Intervertebral Disc. Doctoral Thesis in Engineering. <strong>University</strong> of<br />

Stuttgart: Waiblingen, 197.<br />

6. Kapandji, A. I. (2000). Fisiologia Articular – Esquemas Comentados de Mecânica<br />

Humana. Editorial Médica Panamericana S.A.<br />

7. Raj, P. P., Intervertebral Disc: Anatomy-Physiology-Pathophysiology-Treatment,<br />

Pain Practice, 2008, 8, 1, 18-44.<br />

8. Alves, J. L., Yamamura, N., Oda, T. and Teodosiu, C., Numerical simulation of<br />

musculo-skeletal systems by V-Biomech, Proceedings of <strong>CMBBE</strong>2010 Symposium,<br />

2010, 43–48.<br />

9. Eberlein, R, Holzapfel, G.A., Fröhlich, M. (2004) Multi-segment FEA of the human<br />

lumbar spine including the heterogeneity of the annulus fibrosus. Computational<br />

Mechanics. 34: 147-163.<br />

10. Eberlein, R, Holzapfel, G.A., Schulze-Bauer, C.A.J. (2001) An anisotropic model<br />

for annulus tissue and enhanced finite element analyses of intact lumbar disc bodies.<br />

Comput. Meth. Biomech. Biomed. Eng. 4: 209–229.<br />

11. Castro, A., Wilson, W., Huyghe, J.M., Ito, K. and Alves, J. L., A poroelastic<br />

approach for an open source finite element model of the intervertebral disc,<br />

Accepted for <strong>CMBBE</strong><strong>2012</strong> Symposium, <strong>2012</strong>.<br />

12. Schmidt, H., Kettler, A., Rohlmann, A., Claes, L., Wilke, H-J. (2007) The risk of<br />

disc prolapses with complex loading in different degrees of disc degeneration – A<br />

finite element analysis. Clin Biomech; 22: 988–998.

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